Cross-linked polymer matrices, and methods of making and using same
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
C08B-015/00
출원번호
US-0470164
(2006-09-05)
등록번호
US-8673333
(2014-03-18)
발명자
/ 주소
Elisseeff, Jennifer
Tuan, Rocky S.
Li, Qiang
Wang, Dongan
Silverman, Ronald Paul
출원인 / 주소
The Johns Hopkins University
대리인 / 주소
Edwards Wildman Palmer LLP
인용정보
피인용 횟수 :
2인용 특허 :
35
초록▼
Functionalized chondroitin sulfate, cross-linked polymer matrices comprising functionalized chondroitin sulfate, and methods of making and using the same are provided. Such polymer matrices may be used for tissue engineering, reconstructing cartilage, and the like. Kits are also provided for detecti
Functionalized chondroitin sulfate, cross-linked polymer matrices comprising functionalized chondroitin sulfate, and methods of making and using the same are provided. Such polymer matrices may be used for tissue engineering, reconstructing cartilage, and the like. Kits are also provided for detection of cartilage degrading enzymes.
대표청구항▼
1. A composition comprising a cross-linked polymer matrix, the cross-linked polymer matrix comprising functionalized chondroitin sulfate, wherein the functionalized chondroitin sulfate comprises at least 100 monomeric units, and at least one polymerizing moiety per about 10 monomeric units, wherein
1. A composition comprising a cross-linked polymer matrix, the cross-linked polymer matrix comprising functionalized chondroitin sulfate, wherein the functionalized chondroitin sulfate comprises at least 100 monomeric units, and at least one polymerizing moiety per about 10 monomeric units, wherein the polymerizing moiety is a methacrylate moiety, and wherein at least one monomeric unit of the functionalized chondroitin sulfate is cross-linked into the cross-linked polymer matrix. 2. The composition of claim 1, wherein said monomeric unit of chondroitin sulfate is functionalized with an aldehyde moiety. 3. The composition of claim 1, wherein said cross-linked polymer matrix is a hydrogel. 4. The composition of claim 1, further comprising a detectable agent. 5. The composition of claim 1, further comprising a biologically active agent. 6. The composition of claim 4, wherein said detectable agent is a dye. 7. The composition of claim 6 wherein said dye is a fluorescent agent. 8. The composition of claim 5, wherein said biologically active agent is a chondrocyte. 9. The composition of claim 5, wherein said biologically active agent is a mesenchymal stem cell. 10. The composition of claim 1, wherein said cross-linked polymer matrix further comprises at least one monomeric unit of a biocompatible polymer. 11. The composition of claim 1, wherein said cross-linked polymer matrix further comprises a compound comprising an amine moiety. 12. The composition of claim 11, wherein said compound is a protein. 13. The composition of claim 11, wherein said compound is albumin. 14. The composition of claim 10, wherein said biocompatible polymer is poly(ethylene glycol). 15. The composition of claim 10, wherein said cross-linked polymer matrix by weight comprises at least 75% of said biocompatible polymer by weight. 16. The composition of claim 10, wherein said cross-linked polymer matrix by weight comprises at least 50% of said biocompatible polymer by weight. 17. The composition of claim 10, wherein said cross-linked polymer matrix by weight comprises at least 25% of said biocompatible polymer by weight. 18. The composition of claim 1, wherein said functionalized chondroitin sulfate is functionalized with an aldehyde moiety and a methacrylate moiety.
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