초록 ▼

A kit and methods for delivering an effective amount of a labile active to the skin are provided. The kit and methods comprise a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the

A kit and methods for delivering an effective amount of a labile active to the skin are provided. The kit and methods comprise a composition comprising an effective amount of a labile active agent incorporated into a water-soluble polymeric film and an additive composition capable of dissolving the water-soluble polymeric film.

대표청구항 ▼

1. A method for treating age spots on skin for improvement comprising applying to the individual age spots for a period of two to eight weeks a patch comprised of a dried water soluble cellulose ether polymeric film impregnated with at least one skin lightening agent effective to lighten age spots,

1. A method for treating age spots on skin for improvement comprising applying to the individual age spots for a period of two to eight weeks a patch comprised of a dried water soluble cellulose ether polymeric film impregnated with at least one skin lightening agent effective to lighten age spots, which is normally labile in one or more of air, light, heat, water, or metal; and at least one plasticizer selected from polyethylene glycol, butylene glycol, glycerin, propylene glycol, or mixtures thereof; wherein the activity of the labile active is maintained in the cellulose ether polymeric film; followed by application of at least one water based additive composition to the film in an amount sufficient to cause the film to completely dissolve and deposit the lightening agent in its active form onto the age spots and improve the appearance of the age spots 25% to 47% over baseline. 2. The method of claim 1 wherein the skin lightening agent is a polyphenol. 3. The method of claim 1 wherein the skin lightening agent is a tea extract. 4. The method of claim 1 wherein the skin lightening agent is green tea extract. 5. The method of claim 1 wherein the water soluble cellulose ether polymer is operable to produce a tacky film when applied to skin. 6. The method of claim 1 wherein the water soluble cellulose ether polymer is nitrocellulose, carboxymethylethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, or mixtures thereof. 7. The method of claim 1 wherein the water based additive composition comprises silicone. 8. The method of claim 7 wherein the water based additive composition comprises dimethicone, cyclomethicone, or mixtures thereof 9. The method of claim 1 wherein the patch is stored in an air tight packet. 10. The method of claim 1 wherein the additive composition is stored in a bottle. 11. The method of claim 1 wherein the patch is applied to the age spots to be treated at once per day. 12. The method of claim 1 wherein the patch is applied to the age spots once per day in the morning. 13. The method of claim 1 which consists essentially of applying to the individual age spots for a period of two to eight weeks a patch comprised of a dried water soluble cellulose ether polymeric film impregnated with at least one skin lightening agent effective to lighten age spots, which is normally labile in one or more of air, light, heat, water, or metal and at least one plasticizer selected from polyethylene glycol, butylene glycol, glycerin, propylene glycol, or mixtures thereof; wherein the activity of the labile active is maintained in the cellulose ether polymeric film; followed by application of at least one water based additive composition to the film in an amount sufficient to cause the film to completely dissolve and deposit the lightening agent in its active form onto the age spots and improves the appearance of the age spots 25% to 47% over baseline. 14. The method of claim 13 wherein the patches are applied to one or more individual age spots once per day in the morning.