Methods, systems, and apparatus for assessing a state of a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fit
Methods, systems, and apparatus for assessing a state of a comorbidity associated with a primary disease are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of a body system of the patient that is a site of the comorbidity, based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.
대표청구항▼
1. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method for assessing a body system for an emergence of a comorbidity associated with a primary disease, comprising: receiving at least one of an autonomic index, a neurol
1. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method for assessing a body system for an emergence of a comorbidity associated with a primary disease, comprising: receiving at least one of an autonomic index, a neurologic index, a stress marker index, a psychiatric index, an endocrine index, or a quality of life index of a patient;comparing the at least one index to at least one reference value associated with the at least one index;assessing a susceptibility of a the body system to the emergence of the comorbidity at least partially caused by the primary disease based on the comparing, wherein the body system comprises at least one of an autonomic system, a neurologic system, a psychiatric system, an endocrine system, or subsystems of the foregoing; andproviding an output relating to the assessing, wherein the output comprises at least one of increased susceptibility, decreased susceptibility, stable susceptibility, or a determination that a the susceptibility cannot be determined. 2. The non-transitory computer readable program storage unit of claim 1, wherein the method further comprises assessing a susceptibility of a second body system to the comorbidity associated with the primary disease based on the comparing, wherein the second body system comprises at least one of an autonomic system, a neurologic system, a psychiatric system, an endocrine system, or subsystems of the foregoing, and the output comprises at least one of second increased susceptibility, second decreased susceptibility, second stable susceptibility, or a determination that the susceptibility cannot be determined. 3. The non-transitory computer readable program storage unit of claim 1, wherein the output further comprises at least one of a magnitude of a change of an increased susceptibility, a magnitude of a change of a decreased susceptibility, a rate of change of an increased susceptibility, or a rate of change of a decreased susceptibility. 4. The non-transitory computer readable program storage unit of claim 1, wherein the method further comprises assessing a state of the primary disease of the patient based on comparing at least one second index to at least one second reference value, wherein the output further comprises primary disease stability, primary disease progression, primary disease regression, or a finding that a primary disease state cannot be determined. 5. The non-transitory computer readable program storage unit of claim 4, wherein the output further comprises identifying at least a second comorbidity associated with the primary disease. 6. The non-transitory computer readable program storage unit of claim 4, wherein the method further comprises providing a warning signal to the patient, a physician, or a caregiver if the output comprises primary disease progression, primary disease regression, or primary disease state indeterminability. 7. The non-transitory computer readable program storage unit of claim 6, wherein the warning signal is proportional to at least one of a magnitude of a change of a progression, a rate of change of a progression, or a role of the body system in the overall health of the patient. 8. The non-transitory computer readable program storage unit of claim 1, wherein the primary disease is epilepsy; receiving comprises receiving at least one autonomic index selected from a cardiovascular parameter, a respiration parameter, a body temperature parameter, a skin resistance parameter, or two or more thereof; and at least one neurologic index selected from an attention aptitude parameter, a responsiveness parameter, a memory parameter, a kinetic parameter, a cognitive aptitude parameter, a quality of life parameter, or two or more thereof. 9. The non-transitory computer readable program storage unit of claim 8, wherein receiving further comprises receiving at least one stress marker index selected from a cortisol parameter, a catecholamine parameter, a lactic acid parameter, or two or more thereof. 10. The non-transitory computer readable program storage unit of claim 8, wherein the at least one autonomic index comprises at least one of a cardiovascular parameter or a respiratory parameter, and the at least one neurologic index comprises at least one of a responsiveness parameter or a kinetic parameter. 11. The non-transitory computer readable program storage unit of claim 1, wherein the method further comprises forecasting a state of the body system, wherein the forecast comprises a body system stability, a body system improvement, a body system deterioration, or a finding that no forecast can be made. 12. The non-transitory computer readable program storage unit of claim 1, wherein receiving comprises receiving a plurality of autonomic indices, neurologic indices, stress marker indices, psychiatric indices, endocrine indices, physical fitness indices, quality of life indices, or two or more thereof; and the at least one index comprises a weighted composite of the plurality of autonomic indices, neurologic indices, stress marker indices, psychiatric indices, endocrine indices, physical fitness indices, quality of life indices, or two or more thereof. 13. The non-transitory computer readable program storage unit of claim 1, wherein the at least one reference value is based on the patient's index value history or on normative data. 14. The non-transitory computer readable program storage unit of claim 1, wherein the at least one index comprises a measure of central tendency, a measure of dimensionality, a measure of fractality, a measure of stationarity, a measure of long-range dependency, a measure of clustering, a distribution of measures of central tendency, a distribution of measures of dimensionality, a distribution of measures of fractality, a distribution of measures of stationarity, a distribution of measures of long-range dependency, a distribution of measures of clustering, or two or more thereof. 15. The non-transitory computer readable program storage unit of claim 1, wherein an output of an increased susceptibility is indicative of a deterioration of the patient's health, an output of a decreased susceptibility is indicative of an improvement of the patient's health, an output of a stable susceptibility is indicative of a stability of the patient's health, an output of deterioration in quality of life is indicative of a deterioration of the patient's mental health, an output of improvement in quality of life is indicative of an improvement of the patient's mental health, or an output of indeterminability of susceptibility is indicative of indeterminability of the patient's health. 16. The non-transitory computer readable program storage unit of claim 4, wherein an output of primary disease deterioration is indicative of a deterioration of the patient's health, an output of primary disease improvement is indicative of an improvement of the patient's health, an output of primary disease stability is indicative of a stability of the patient's health, or an output of indeterminability of a primary disease is indicative of indeterminability of the patient's health. 17. The non-transitory computer readable program storage unit of claim 12, further comprising determining the state of health of a patient using said weighted composite index. 18. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform a method for assessing a body system for an emergence of a comorbidity associated with a primary disease, comprising: receiving a first index selected from the group consisting of an autonomic index, a neurologic index, a stress marker index, a psychiatric index, an endocrine index, a physical fitness index, and a quality of life index of a patient;comparing the first index to at least one reference value associated with the at least first index;assessing a susceptibility of a body system to the emergence of the comorbidity at least partially caused by the primary disease based on the comparing, wherein the body system comprises at least one of an autonomic system, a neurologic system, a psychiatric system, an endocrine system, or subsystems of the foregoing;assessing a state of the patient's health based on the assessing the susceptibility of the body system to the emergence of the comorbidity; andproviding an output relating to at least one of the assessment of the susceptibility of the body system or the assessment of the state of the patient's health, wherein the output comprises at least one of increased susceptibility, decreased susceptibility, stable susceptibility, a determination that the susceptibility of the body system cannot be determined, a stable health state, a poorer health state, an improved health state, or a finding that the state of the patient's health cannot be determined. 19. A medical device system, comprising: a body index determination unit capable of determining at least one of an autonomic index, at least one neurologic index, at least one stress marker index, at least one psychiatric index, at least one endocrine index, at least one adverse effect of therapy index, at least one physical fitness index, or at least one quality of life index;an index comparison unit capable of comparing at least one said index with at least one reference value;a body system susceptibility assessment unit capable of assessing a susceptibility of a body system to an emergence of a comorbidity at least partially caused by a primary disease of a patient, wherein the body system comprises at least one of an autonomic system, a neurologic system, a psychiatric system, an endocrine system, an hepatic system, a renal system, a bone marrow system, a skin system, or subsystems of the foregoing; andan output unit capable of providing an output relating to the assessing, wherein the output comprises at least one of increased susceptibility, decreased susceptibility, stable susceptibility, or a determination that a susceptibility of the body system cannot be determined. 20. The non-transitory computer readable program storage unit of claim 1, wherein the method further comprises providing a warning signal to the patient, a physician, or a caregiver if the output comprises increased susceptibility or indeterminability of susceptibility.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (213)
Birinder Bob Boveja, APPARATUS AND METHOD FOR ADJUNCT (ADD-ON) THERAPY FOR DEPRESSION, MIGRAINE, NEUROPSYCHIATRIC DISORDERS, PARTIAL COMPLEX EPILEPSY, GENERALIZED EPILEPSY AND INVOLUNTARY MOVEMENT DISORDERS UTILIZING AN .
Esteller, Rosana; Echauz, Javier Ramon; Litt, Brian; Vachtsevanos, George John, Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control.
Esteller,Rosana; Echauz,Javier Ram?n; Litt,Brian; Vachtsevanos,George John, Adaptive method and apparatus for forecasting and controlling neurological disturbances under a multi-level control.
Boveja Birinder Bob, Apparatus and method for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and external stimulator.
Boveja Birinder Bob, Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator.
Boveja, Birinder R., Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator.
Boveja, Birinder R., Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator.
Boveja, Birinder R., Apparatus and method for neuromodulation therapy for obesity and compulsive eating disorders using an implantable lead-receiver and an external stimulator.
Nelson,Chester Gary; Lee,Michael Thomas; Schrenk,Michael G., Apparatus and method for remote therapy and diagnosis in medical devices via interface systems.
Boveja, Birinder R., Apparatus and method for treatment of neurological and neuropsychiatric disorders using programmerless implantable pulse generator system.
Boveja, Birinder R., Apparatus for adjunct (add-on) therapy of Dementia and Alzheimer's disease utilizing an implantable lead and an external stimulator.
Gust H. Bardy, Automated collection and analysis patient care system and method for ordering and prioritizing multiple health disorders to identify an index disorder.
Adkins Robert A. ; O'Donovan Cormac A. ; Terry ; Jr. Reese S., Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity.
Olsen Dale E. (Columbia MD) Lesser Ronald P. (Baltimore MD) Harris John C. (Gaithersburg MD) Webber W. Robert S. (Howard County MD) Cristion John A. (Columbia MD), Automatic detection of seizures using electroencephalographic signals.
Robert W. Stadler ; Shannon Nelson, Axis shift analysis of electrocardiogram signal parameters especially applicable for multivector analysis by implantable medical devices, and use of same.
Stadler Robert W. ; Nelson Shannon, Axis shift analysis of electrocardiogram signal parameters especially applicable for multivector analysis by implantable medical devices, and use of same.
Kieval Robert S. ; Bettett Tom D. ; Fitts Stephanie Michele, Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure.
Frei,Mark G.; Osorio,Ivan; Rise,Mark T.; Giftakis,Jonathon E.; Graves,Nina M.; Carlson,David L.; Jensen,Randy M., Channel-selective blanking for a medical device system.
Frei,Mark G.; Osorio,Ivan; Graves,Nina M.; Schaffner,Scott F.; Rise,Mark T.; Giftakis,Jonathon E.; Carlson,David L., Clustering of recorded patient neurological activity to determine length of a neurological event.
Sumner, II,Walton; Hagen,Michael D., Computer architecture and process of patient generation, evolution and simulation for computer based testing system using bayesian networks as a scripting language.
Terry ; Jr. Reese F. (Houston TX) Stanislaw Henry (Blairstown NJ) Varrichio Anthony J. (Flanders NJ) Winstrom William L. (Andover NJ), Constant current sources with programmable voltage source.
Christophersom, Mark A.; Donders, Adrianus P.; Miesel, Keith A.; Twetan, Len D., Externally worn transceiver for use with an implantable medical device.
Nappholz Tibor A. (Englewood CO) Hursta William N. (Littleton CO) Dawson Albert K. (Denver CO) Steinhaus Bruce M. (Parker CO), Implantable ambulatory electrocardiogram monitor.
Fischell Robert E. ; Fischell David R. ; Fischell Tim A., Implantable electronic system with acute myocardial infarction detection and patient warning capabilities.
Gianni Plicchi IT; Bruno Garberoglio IT; Guido Gaggini IT; Luigi Silvestri IT; Laura Vaccarone IT; Emanuela Marcelli IT, Implantable heart stimulation system with automatic mode switching controlled by sympatho-vagal balance.
Baker ; Jr. Ross G. (Houston TX) Terry ; Jr. Reese S. (Houston TX), Implantable medical device with dummy load for pre-implant testing in sterile package and facilitating electrical lead c.
Loeb, Gerald E.; Richmond, Francis J. R.; Mann, Carla M.; Faltys, Michael A.; Whitehurst, Todd K.; McGivern, James P., Implantable stimulator system and method for treatment of incontinence and pain.
Varrichio Anthony J. (Flanders NJ) Winstrom William L. (Andover NJ), Implanted apparatus disabling switching regulator operation to allow radio frequency signal reception.
Stanislaw Henry (Blairstown NJ), Implanted apparatus having micro processor controlled current and voltage sources with reduced voltage levels when not p.
Nolan James A. (Conifer CO) Steinhaus Bruce M. (Parker CO) Nappholz Tibor A. (Englewood CO), Leadless implantable sensor assembly and a cardiac emergency warning alarm.
Robert E. Fischell ; David R. Fischell ; Adrian R. M. Upton CA; Dennis R. Potts ; Benjamin D. Pless, Means and method for the intracranial placement of a neurostimulator.
Noren Kjell (Solna SEX) Hirschberg Jakub (Taby SEX), Medical therapy apparatus which administers therapy adjusted to follow natural variability of the physiological function.
Persen,Kenneth H.; Von Arx,Jeffrey A.; Larson,Dennis Eric; Vallapureddy,Vineel; Woellenstein,Matthias Daniel; Hein,Jason Dean, Method and apparatus for communication between a handheld programmer and an implantable medical device.
Stroetmann Brigitte (Uttenreuth DEX) Mund Konrad (Uttenreuth DEX) Kallert Siegfried (Erlangen DEX), Method and apparatus for detecting a state of imminent cardiac arrhythmia in response to a nerve signal from the autonom.
Boveja, Birinder R.; Widhany, Angely, Method and apparatus for electrical stimulation adjunct (add-on) treatment of urinary incontinence and urological disorders using an external stimulator.
Stadler Robert ; Nelson Shannon ; Stylos Lee ; Sheldon Todd J., Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals.
Brockway,Marina; Lincoln,William C.; Carlson,Gerrard M., Method and apparatus for optimization of cardiac resynchronization therapy using heart sounds.
Geddes Leslie A. (West Lafayette IN) Elabbady Tarek (Kirkland WA) Schoenlein William E. (Lafayette IN) Waninger Matthew (Frankfort IN) Bourland Joe D. (West Lafayette IN), Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation.
Geddes Leslie A. ; Elabbady Tarek ; Schoenlein William E. ; Waninger Matthew ; Bourland Joe D., Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation.
Corbucci Giorgio (San Giovanni In Persiceto ITX), Method and device for monitoring and detecting sympatho-vagal activity and for providing therapy in response thereto.
Hill, Michael R. S.; Jahns, Scott E.; Keogh, James R.; Euler, David E.; Ujhelyi, Michael R.; Rakow, Nancy J., Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure.
Hill, Michael R. S.; Jahns, Scott E.; Keogh, James R., Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia.
Geddes Leslie A. (West Lafayette IN) Bourland Joe D. (West Lafayette IN) Terry Reese S. (Freeport TX), Method of and apparatus for automatically detecting and treating ventricular fibrillation.
Andres M. Lozano CA; Mark T. Rise, Method of treating movement disorders by electrical stimulation and/or drug infusion of the pendunulopontine nucleus.
Nikitin, Alexei V.; Frei, Mark G.; Bhavaraju, Naresh C.; Osorio, Ivan, Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes.
Nikitin, Alexei V.; Frei, Mark G.; Bhavaraju, Naresh C.; Osorio, Ivan; Davidchack, Ruslan, Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes.
Nikitin,Alexei V.; Frei,Mark G.; Bhavaraju,Naresh C.; Osorio,Ivan, Method, computer program, and system for automated real-time signal analysis for detection, quantification, and prediction of signal changes.
Frei,Mark G.; Osorio,Ivan, Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale.
Frei,Mark G.; Osorio,Ivan, Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale.
Firlik,Andrew D.; Balzer,Jeffrey; Gliner,Bradford E.; Levy,Alan J.; Morgan,Carlton B., Methods and apparatus for effectuating a lasting change in a neural-function of a patient.
Naritoku, Dean K.; Jensen, Robert A.; Browning, Ronald A.; Clark, Kevin B.; Smith, Douglas C.; Terry, Jr., Reese S., Methods for improving learning or memory by vagus nerve stimulation.
Dean K. Naritoku ; Robert A. Jensen ; Ronald A. Browning ; Kevin B. Clark ; Douglas C. Smith ; Reese S. Terry, Jr., Methods of modulating aspects of brain neural plasticity by vagus nerve stimulation.
Naritoku Dean K. ; Jensen Robert A. ; Browning Ronald A. ; Clark Kevin B. ; Smith Douglas C. ; Terry ; Jr. Reese S., Methods of treating traumatic brain injury by vagus nerve stimulation.
Klein George J.,CAX ; Warkentin Dwight H. ; Riff Kenneth M. ; Lee Brian B. ; Carney James K. ; Turi Gregg ; Varrichio Anthony J., Minimally invasive implantable device for monitoring physiologic events.
Sackellares,James Chris; Iasemidis,Leonidas D.; Shiau,Deng Shan; Dance,Linda; Pardalos,Panos M.; Chaovalitwongse,Wanpracha A., Multi-dimensional multi-parameter time series processing for seizure warning and prediction.
David R. Fischell ; Jonathan Harwood ; Benjamin D. Pless, Neurological event detection procedure using processed display channel based algorithms and devices incorporating these procedures.
Sackellares,James Chris; Iasemidis,Leonidas D.; Shiau,Deng Shan; Dance,Linda, Optimization of multi-dimensional time series processing for seizure warning and prediction.
Varrichio Anthony J. (Flanders NJ) Winstrom William L. (Andover NJ) Stanislaw Henry (Blairstown NJ), Simultaneous radio frequency and magnetic field microprocessor reset circuit.
Osorio,Ivan; Bhavaraju,Naresh C.; Peters,Thomas E.; Frei,Mark G.; Werder,Jonathan C., Synchronization and calibration of clocks for a medical device and calibrated clock.
Osorio,Ivan; Bhavaraju,Naresh C.; Peters,Thomas E.; Frei,Mark G.; Werder,Jonathan C., Synchronization and calibration of clocks for a medical device and calibrated clock.
Misczynski, Dale Julian; Bukhman, Vladislav; Tymoshok, Sergii; Tymoshok, Dmytro; Sychov, Oleg Sergeevich, System and process for analyzing a medical condition of a user.
Osorio, Ivan; Frei, Mark; Lerner, David; Ralston, John; Dorfmeister, Josef, System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject.
Dorfmeister Josef ; Frei Mark ; Lerner David ; Osorio Ivan ; Ralston John, System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain o.
Gliner,Bradford Evan; Balzer,Jeffrey; Firlik,Andrew D., Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators.
Gliner,Bradford Evan, Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders.
Gliner,Bradford Evan; Wyler,Allen; Fowler,Brad; Sheffield,W. Douglas, Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of movement disorders and/or other neurologic dysfunction.
Gliner,Bradford E.; Sheffield,Warren D., Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation.
Gliner,Bradford Evan; Leyde,Kent, Systems and methods for reducing the likelihood of inducing collateral neural activity during neural stimulation threshold test procedures.
Terry ; Jr. Reese S. (Houston TX) Wernicke Joachim F. (League City TX) Baker ; Jr. Ross G. (Houston TX), Therapeutic treatment of migraine symptoms by stimulation.
Frei,Mark G.; Osorio,Ivan; Bhavaraju,Naresh C.; Carlson,David L.; Giftakis,Jonathon E.; Graves,Nina M., Timed delay for redelivery of treatment therapy for a medical device system.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX) Marquette Andre (Stamford CT), Treatment of motility disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Zabara Jacob (Philadelphia PA), Treatment of neuropsychiatric disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of patients in coma by nerve stimulation.
Osorio,Ivan; Bhavaraju,Naresh C., Unitized electrode with three-dimensional multi-site, multi-modal capabilities for detection and control of brain state changes.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.