최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0718332 (2010-03-05) |
등록번호 | US-8682408 (2014-03-25) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 26 인용 특허 : 394 |
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The se
Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.
1. A device for continuous measurement of an analyte concentration, the device comprising: an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host; anda membrane located over the sensor;wherein the device is configured to provide,
1. A device for continuous measurement of an analyte concentration, the device comprising: an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host; anda membrane located over the sensor;wherein the device is configured to provide, at analyte concentrations of from 40 mg/dL to 80 mg/dL, a level of accuracy corresponding to a mean absolute relative difference of no more than 10% over a sensor session of at least 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood. 2. The device of claim 1, wherein the membrane comprises an enzyme configured to react with the analyte. 3. The device of claim 1, wherein the membrane comprises a copolymer and a hydrophilic portion. 4. The device of claim 1, wherein the copolymer comprises a polyurethane. 5. The device of claim 4, wherein the copolymer further comprises a silicone segment. 6. The device of claim 5, wherein the copolymer further comprises a polycarbonate segment. 7. The device of claim 1, wherein the device is configured to provide, at analyte concentrations of from 40 mg/dL to 400 mg/dL, a level of accuracy of a mean absolute relative difference of no more than 10% over the sensor session, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood. 8. The device of claim 7, wherein the mean absolute relative difference corresponding to measurements at analyte concentrations of from 40 mg/dL to 80 mg/dL is from 6% to 10%. 9. The device of claim 1, wherein the mean absolute relative difference corresponding to measurements at analyte concentrations of from 40 mg/dL to 80 mg/dL is from 4.9% to 10%. 10. The device of claim 1, wherein the membrane comprises a material that is a polymer produced by a reaction of an isocyanate. 11. The device of claim 10, wherein the isocyanate is a polyisocyanate. 12. The device of claim 11, wherein the polyisocyanate is a diisocyanate. 13. The device of claim 1, wherein the sensor comprises an electrode configured to oxidize a measured species that is a product of an enzyme-catalyzed reaction with the analyte, whereby the signal is generated. 14. A system for continuous measurement of an analyte concentration, the system comprising: an implantable sensor comprising a sensing region configured to continuously produce in vivo sensor data associated with an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensing region;a processor configured to process continuous sensor data; anda user interface configured to display information associated with continuous sensor data;wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL and 400 mg/dL, a level of accuracy of a mean absolute relative difference of no more than 10% over a sensor session of at least 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood. 15. The system of claim 14, wherein the membrane comprises an enzyme configured to react with the analyte. 16. The device of claim 14, wherein the membrane comprises a copolymer and a hydrophilic portion. 17. The device of claim 14, wherein the copolymer comprises a polyurethane. 18. The device of claim 17, wherein the copolymer further comprises a silicone segment. 19. The device of claim 18, wherein the copolymer further comprises a polycarbonate segment. 20. The system of claim 14, wherein the sensor is configured to provide, at analyte concentrations of from 40 mg/dL to 80 mg/dL, a level of accuracy of a mean absolute relative difference of no more than 10% over a sensor session of at least 3 days, wherein one or more reference measurements associated with calculation of the mean absolute relative difference are determined by analysis of blood. 21. The system of claim 20, wherein the mean absolute relative difference corresponding to measurements at analyte concentrations of from 40 mg/dL to 80 mg/dL is from 6% to 10%. 22. The system of claim 14, wherein the mean absolute relative difference corresponding to measurements at analyte concentrations of from 40 mg/dL to 400 mg/dL is from 6.8% to 10%. 23. The system of claim 14, wherein the membrane comprises a material that is a polymer produced by a reaction of an isocyanate. 24. The system of claim 23, wherein the isocyanate is a polyisocyanate. 25. The system of claim 24, wherein the polyisocyanate is a diisocyanate. 26. The system of claim 14, wherein the sensor comprises an electrode configured to oxidize a measured species that is a product of an enzyme-catalyzed reaction with the analyte, whereby the signal is generated. 27. A device for continuous measurement of an analyte concentration, the device comprising: an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host; anda membrane located over the sensor;wherein, over a sensor session of at least 3 days, the device is configured to: provide a level of accuracy corresponding to a first mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 80 mg/dL, wherein one or more reference measurements associated with calculation of the first mean absolute relative difference are determined by analysis of blood; andprovide a level of accuracy corresponding to a second mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 400 mg/dL, wherein one or more reference measurements associated with calculation of the second mean absolute relative difference are determined by analysis of blood; andwherein the first mean absolute relative difference value is less than or equal to the second mean absolute relative difference value. 28. The device of claim 27, wherein the membrane comprises an enzyme configured to react with the analyte. 29. The device of claim 27, wherein the membrane comprises a copolymer and a hydrophilic portion. 30. The device of claim 27, wherein the copolymer comprises a polyurethane. 31. The device of claim 30, wherein the copolymer further comprises a silicone segment. 32. The device of claim 31, wherein the copolymer further comprises a polycarbonate segment. 33. The device of claim 27, wherein the first mean absolute relative difference value is from 4.9% to 10%. 34. The device of claim 27, wherein the membrane comprises a material that is a polymer produced by a reaction of an isocyanate. 35. The device of claim 34, wherein the isocyanate is a polyisocyanate. 36. The device of claim 35, wherein the polyisocyanate is a diisocyanate. 37. The device of claim 27, wherein the sensor comprises an electrode configured to oxidize a measured species that is a product of an enzyme-catalyzed reaction with the analyte, whereby the signal is generated. 38. A system for continuous measurement of an analyte concentration, the system comprising: an implantable sensor configured to continuously measure in vivo a signal associated with an analyte concentration in a host, wherein the sensor further comprises a membrane located over the sensor;a processor configured to process continuous sensor data; anda user interface configured to display information associated with continuous sensor data;wherein, over a sensor session of at least 3 days, the system is configured to: provide a level of accuracy corresponding to a first mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 80 mg/dL, wherein one or more reference measurements associated with calculation of the first mean absolute relative difference are determined by analysis of blood; andprovide a level of accuracy corresponding to a second mean absolute relative difference value at analyte concentrations of from 40 mg/dL to 400 mg/dL, wherein one or more reference measurements associated with calculation of the second mean absolute relative difference are determined by analysis of blood; andwherein the first mean absolute relative difference value is less than or equal to the second mean absolute relative difference value. 39. The system of claim 38, wherein the membrane comprises an enzyme configured to react with the analyte. 40. The device of claim 38, wherein the membrane comprises a copolymer and a hydrophilic portion. 41. The device of claim 38, wherein the copolymer comprises. 42. The device of claim 41, wherein the copolymer further comprises a silicone segment. 43. The device of claim 42, wherein the copolymer further comprises a polycarbonate segment. 44. The system of claim 38, wherein the first mean absolute relative difference value is from 4.9% to 10%. 45. The system of claim 38, wherein the membrane comprises a material that is a polymer produced by a reaction of an isocyanate. 46. The system of claim 45, wherein the isocyanate is a polyisocyanate. 47. The system of claim 46, wherein the polyisocyanate is a diisocyanate. 48. The system of claim 38, wherein the sensor comprises an electrode configured to oxidize a measured species that is a product of an enzyme-catalyzed reaction with the analyte, whereby the signal is generated.
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