IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0849574
(2010-08-03)
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등록번호 |
US-8682440
(2014-03-25)
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발명자
/ 주소 |
- Imran, Mir A.
- Hashim, Mir
- Arnsdorf, Emily
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출원인 / 주소 |
|
대리인 / 주소 |
Wilson Sonsini Goodrich & Rosati
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인용정보 |
피인용 횟수 :
34 인용 특허 :
20 |
초록
▼
Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-
Embodiments of the invention provide apparatus and methods for stimulating L cells in the intestinal tract to produce incretins for the treatment of conditions including diabetes and obesity. Many embodiments provide a method and apparatus for the treatment of diabetes by electrically stimulating L-cells to secrete incretins to stimulate or otherwise modulate the production of insulin. Particular embodiments provide a swallowable capsule for stimulating L-cells in the intestinal tract as the capsule moves through the tract. The capsule can include two or more electrodes for providing electrical stimulation to L-cells, a power source for powering one or more components of the capsule, a sensor for sensing the location of the capsule in the intestinal tract; a controller and a waveform generator for generating the electrical signals emitted by the electrodes to stimulate the L-cells to secrete incretins such as GLP-1 to stimulate insulin production for glucose regulation of diabetic conditions.
대표청구항
▼
1. A swallowable capsule for stimulating L-cells in the intestinal track of a patient, the capsule comprising: a capsule body having a surface;the capsule body sized to be swallowed and pass through the intestinal tract of a patient;at least one pair of electrodes disposed on the capsule body surfac
1. A swallowable capsule for stimulating L-cells in the intestinal track of a patient, the capsule comprising: a capsule body having a surface;the capsule body sized to be swallowed and pass through the intestinal tract of a patient;at least one pair of electrodes disposed on the capsule body surface configured to electrically stimulate the L-cells;at least one sensor coupled to the capsule body for sensing a property of the intestinal track to determine a location of the capsule within the intestinal tract;a controller coupled to the least one pair of electrodes and the at least one sensor, the controller disposed within the capsule body and configured to receive an input signal from the least one sensor, determine a location of the capsule within the intestinal tract based on the input and generate a waveform outputted to the at least one pair of electrodes, the waveform configured to electrically stimulate L-cells proximate the capsule location to secrete a polypeptide without causing a peristaltic contraction the intestinal tract;a power source coupled to the controller;and wherein the capsule is configured to electrically stimulate L-cells along an entire length of the intestinal tract. 2. The capsule of claim 1, wherein the secreted polypeptide is one of incretin or GLP-1. 3. The capsule of claim 1, wherein the controller is configured to initiate generation of the waveform when the capsule reaches a selectable location in the intestinal tract. 4. The capsule of claim 3, wherein the selectable location is the proximate of the small intestine. 5. The capsule of claim 1, wherein the waveform is activated by contact of the capsule with an intestinal wall. 6. The capsule of claim 5, wherein contact is detected by at least one of the least one pair of electrodes or a contact sensor or pressure sensor positioned on the capsule body surface. 7. The capsule of claim 1, wherein a longitudinal axis of the at least one pair electrodes is aligned with respect to a longitudinal axis of the capsule body. 8. The capsule of claim 1, wherein a longitudinal axis of the at least one pair electrodes is aligned with respect to a radial axis of the capsule body. 9. The capsule of claim 1, wherein the at least one pair of electrodes comprise ring shaped electrodes. 10. The capsule of claim 9, wherein the ring shaped electrodes have a coaxial alignment with respect to a longitudinal axis of the capsule body. 11. The capsule of claim 1, wherein the at least one pair of electrodes have a spacing configured to minimize electrical stimulation of tissue subjacent a mucosal layer of the intestinal tract. 12. The capsule of claim 11, wherein the at least one pair of electrodes have a spacing configured to minimize electrical stimulation of tissue more than about 3 to 5 mm subjacent a surface of the mucosal layer of the intestinal tract. 13. The capsule of claim 11, wherein the spacing between the electrodes is in a range between about 0.01 to 0.2 inches. 14. The capsule of claim 11, wherein the spacing between the electrodes is in a range between about 0.05 to 0.2 inches. 15. The capsule of claim 1, wherein the controller includes a signal generator. 16. The capsule of claim 15, wherein the signal generator comprises one of a pulse generator or an H-Bridge. 17. The capsule of claim 15, wherein the signal generator is configured to generate a pulsed signal. 18. The capsule of claim 17, wherein the pulsed signal has a frequency in a range between about 1 to 100 Hz. 19. The capsule of claim 1, wherein the at least one sensor comprises a pressure sensor for sensing a contraction or force of contraction within the intestinal tract. 20. The capsule of claim 1, wherein the at least one sensor comprises a pH sensor for sensing a pH of the intestinal tract or a change in the pH of the intestinal tract as the capsule is moving through the tract. 21. The capsule of claim 1, wherein the at least one sensor comprises a pH sensor and a pressure sensor. 22. The capsule of claim 1, wherein the controller comprises sensor conditioning circuitry for conditioning an input from the at least one sensor. 23. The capsule of claim 22, wherein the conditioning circuitry comprises at least one of a band pass filter, a high pass filter or a low pass filter. 24. The capsule of claim 1, wherein the power source comprises a capacitor, an electrical battery, a lithium battery or a lithium ion battery. 25. The capsule of claim 1, wherein the power source comprises a piezo-electric power source configured to generate electrical power from motion of the capsule though the intestinal tract or mechanical interaction of the capsule with the intestinal tract or the contents of intestinal tract. 26. The capsule of claim 1, wherein the waveform is configured to stimulate L-cells within about 5 cm from the capsule body surface. 27. The capsule of claim 1, wherein the waveform is configured to stimulate L-cells within about 2 cm from the capsule body surface. 28. The capsule of claim 1, wherein the waveform is configured to stimulate L-cells within about 1 cm from the capsule body surface. 29. The capsule of claim 1, further comprising: an accelerometer for sensing motion of the capsule through the intestinal tract, the accelerometer coupled to the controller. 30. The capsule of claim 1, wherein the controller is configured to generate a first and second waveform, the first waveform configured to electrically stimulate L-cells proximate the capsule location to produce a secreted polypeptide without causing a peristaltic contraction of the intestinal tract, the second waveform configured to cause peristaltic contraction of a portion of the intestinal tract proximate the capsule so as to advance the capsule within the intestinal tract. 31. The capsule of claim 30, wherein second waveform is activated responsive to an input indicating that a velocity of capsule motion through the intestinal tract is below a minimum level. 32. The capsule of claim 31, wherein the input is from an accelerometer coupled to the controller. 33. The capsule of claim 30, wherein the first and second waveforms are generated by means of an algorithm electronically stored within the controller or memory resources coupled to the controller. 34. A swallowable capsule for stimulating L-cells in the intestinal track of a patient, the capsule comprising: a capsule body having a surface;the capsule body sized to be swallowed and pass through the intestinal tract of a patient;at least one pair of electrodes disposed on the capsule body surface configured to electrically stimulate the L-cells;at least one sensor coupled to the capsule body for sensing a property of the intestinal track to determine a location of the capsule within the intestinal tract;a controller coupled to the least one pair of electrodes and the at least one sensor, the controller disposed within the capsule body and configured to receive an input signal from the least one sensor, determine a location of the capsule within the intestinal tract based on the input and generate a waveform outputted to the at least one pair of electrodes, the waveform configured to electrically stimulate L-cells proximate the capsule location to secrete a polypeptide without causing or interfering with peristalsis of the intestinal tract; anda power source coupled to the controller.
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