A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained
A medical device for placement in a body of a mammal is provided. The medical device comprises (1) a polymeric matrix forming the device and defining a lumen through the device, the matrix comprising polymer macromolecules and defining spaces between the polymer macromolecules; (2) a drug contained within at least some of the spaces of the matrix; and (3) a material contained within at least some of the spaces of the matrix to affect diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal.
대표청구항▼
1. A medical device selected from a ureteral stent and a urinary catheter for placement in a body of a mammal, comprising: a polymeric matrix forming the medical device entirely or partially and defining a lumen through the medical device, the matrix comprising polymer macromolecules comprising ethy
1. A medical device selected from a ureteral stent and a urinary catheter for placement in a body of a mammal, comprising: a polymeric matrix forming the medical device entirely or partially and defining a lumen through the medical device, the matrix comprising polymer macromolecules comprising ethylene vinyl acetate, wherein the polymer macromolecules have spaces and voids and provided the polymer matrix is not a coating;a drug contained within at least some of the spaces of the matrix; anda material contained within at least some of the spaces of the matrix to affect the rate of diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of the mammal, wherein said material is selected from carboxymethyl cellulose, hydroxypropyl cellulose, dextrin, pore formers, sugar, glucose, starch, hyaluronic acid, chelating agents, polyethylene oxide, and copolymers thereof. 2. A method of drug delivery, comprising: placing a medical device in accordance with claim 1, medical device capable of delivering a therapeutic level of said drug as a first drug to the body at a predetermined time after the medical device is placed into the body; anddirectly providing a second drug to the body via instillation to deliver a therapeutic level of the second drug to the body before the delivery of the first drug at the predetermined time, wherein the second drug is selected from an antispasmodic, an anti-inflammatory drug and a smooth muscle relaxant. 3. The method of claim 2 wherein the providing step comprises providing the second drug which is different than the first drug deliverable by the medical device. 4. The method of claim 2 wherein the providing step comprises providing the second drug which is the same as the first drug deliverable by the medical device. 5. A ureteral stent comprising two retention end portions and a central portion, said ureteral stent comprising a polymeric matrix forming the medical device entirely or partially and defining a lumen through the medical device, the matrix comprising polymer macromolecules comprising ethylene vinyl acetate, and defining spaces between the polymer macromolecules and provided the polymer matrix is not a coating, a drug contained within at least some of the spaces of the matrix, and a material contained within at least some of the spaces of the matrix to affect the rate of diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of a mammal, wherein said material is selected from carboxymethyl cellulose, hydroxypropyl cellulose, dextrin, pore formers, sugar, glucose, starch, hyaluronic acid, chelating agents, polyethylene oxide, and copolymers thereof. 6. A ureteral stent comprising two retention end portions and a central portion, said ureteral stent comprising a polymeric matrix forming the medical device entirely or partially and defining a lumen through the medical device, the polymeric matrix comprising ethylene vinyl acetate (EVA) polymer macromolecules, and defining spaces between the polymer macromolecules, a drug selected from oxybutynin chloride and ketorolac contained within at least some of the spaces of the matrix, and a material contained within at least some of the spaces of the matrix to affect the rate of diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of a mammal, wherein said material is selected from carboxymethyl cellulose, hydroxypropyl cellulose, dextrin, pore formers, sugar, glucose, starch, hyaluronic acid, chelating agents, polyethylene oxide, and copolymers thereof. 7. The method of claim 2, wherein said second drug is delivered to the body by intravesical delivery and the first drug is delivered via said ureteral stent. 8. A medical procedure comprising placing a ureteral stent in accordance with claim 5 in a ureter of a patient. 9. A medical procedure comprising placing a ureteral stent in accordance with claim 6 in a ureter of a patient. 10. A ureteral stent comprising two retention end portions and a central portion, said ureteral stent comprising a polymeric matrix forming the medical device entirely or partially and defining a lumen through the medical device, the matrix comprising polymer macromolecules comprising ethylene vinyl acetate and defining spaces between the polymer macromolecules and provided the polymer matrix is not a coating; a drug contained within at least some of the spaces of the matrix, and a material contained within at least some of the spaces of the matrix to affect the rate of diffusion of the drug out of the polymeric matrix when the medical device is placed in the body of a mammal, wherein said material is selected from carboxymethyl cellulose, hydroxypropyl cellulose, dextrin, pore formers, sugar, glucose, starch, hyaluronic acid, chelating agents, polyethylene oxide, and copolymers thereof. 11. A medical procedure comprising placing a ureteral stent in accordance with claim 10 in a ureter of a patient. 12. The method of claim 2, wherein the second drug is delivered via a ureteral catheter. 13. A method of drug delivery according to claim 2 wherein the instillation is accomplished via a second medical device that is different from said medical device selected from a ureteral stent and a urinary catheter. 14. The method of claim 2, wherein first drug is delivered via said ureteral stent. 15. The method of claim 14, wherein said second drug is delivered by a ureteral catheter. 16. The method of claim 14, wherein the second drug is administered at the distal end of said ureteral stent after placement. 17. The method of claim 14, wherein the first and second drugs are non-steroidal anti-inflammatory drugs. 18. The method of claim 14, wherein the first and second drugs are ketorolac. 19. The method of claim 14, wherein the first and second drugs are anti-spasmodic drugs. 20. The method of claim 14, wherein the first and second drugs are oxybutynin chloride. 21. The ureteral stent of claim 6, wherein the drug is ketorolac. 22. The ureteral stent of claim 6, wherein the drug is oxybutynin chloride.
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Lambert James M. (Centerville OH) Solomon Donald D. (Spring Valley OH) Rhodes Delmer R. (Centerville OH), Expandable catheter having hydrophobic surface.
Sabel Bernhard A. (Kreuzberg 6 8011 Egmating MA DEX) Freese Andrew (115 Whitcomb Ave. Jamaica Plain MA 02130), Extended drug delivery of small, water-soluble molecules.
Miller, Kathleen M.; Sydney, Gregory T.; Geitz, Kurt; Dayton, Peter L.; Sahatjian, Ronald A., Implantable or insertable medical device resistant to microbial growth and biofilm formation.
Ronan John M. ; Thompson Samuel A., Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties.
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Balbierz Daniel J. (San Carlos CA) Walker Jack M. (Portola Valley CA) Thomas Joseph R. (San Carlos CA) Bley Robert S. (Menlo Park CA), Softening expanding ureteral stent.
Kennedy Joseph P. (Akron OH) Puskas Judit E. (Akron OH) Kaszas Gabor (Akron OH) Hager William G. (Akron OH), Thermoplastic elastomers of isobutylene and process of preparation.
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