초록 ▼

In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less

In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less than 1% by weight or less than 0.5% by weight.

대표청구항 ▼

1. A method for producing a pancreatin pellet and/or micropellet, which pellet and/or micropellet has a spherical, ellipsoidal or drop shape, has an axis in the range 0.5 mm to 2.5 mm, comprising the steps ofa) comminuting the pancreases of pigs or cattle and conducting autolysis;b) obtaining a scre

1. A method for producing a pancreatin pellet and/or micropellet, which pellet and/or micropellet has a spherical, ellipsoidal or drop shape, has an axis in the range 0.5 mm to 2.5 mm, comprising the steps ofa) comminuting the pancreases of pigs or cattle and conducting autolysis;b) obtaining a screen filtrate by filtration of the product obtained in step a);c) precipitating the enzymes from the screen filtrate;d) filtering the product of step c) to obtain a filter cake;e) cooling the filter cake to a temperature between about −10° C. to about −40° C., to obtain a sufficient plasticity;f) extruding the cooled filter cake, in the absence of additives and/or binding agents, to form extrudates, wherein extrudable filter cake mass contains residual moisture or organic solvent residues between about 30% to about 50% by weight;g) spheronizing the extrusion obtained in step (f), in the absence of additives and/or binding agents or auxiliary substances, so as to obtain spherical, elliptical or drop-shaped pellets; andh) vacuum drying the pellets obtained in step (g) until a residual moisture content of less than 3% by weight is obtained, so that a dried pancreatin product is produced with a residual moisture content of less than 3% by weight. 2. The method according to claim 1, wherein the pellet produced has a pancreatin content of 100%. 3. The method according to claim 1, which comprises the further step of coating the pancreatin pellet, so as to form a pancreatin core having a coating. 4. The method according to claim 3, wherein the coating comprises an enteric material. 5. The method according to claim 3, wherein the coating consists of pancreatin or is formed from auxiliary materials or binding agents. 6. The method according to claim 3, wherein the coating has a first, inner layer which surrounds the pancreatin core, and further has a second, outer layer. 7. The method according to claim 6, wherein the first layer is formed from auxiliary materials or binding agents. 8. The method according to claim 6, wherein the second layer is formed from an enteric material, wherein the pellet is drop-shaped or spherical in shape. 9. The method according to claim 1, wherein in step (e) the filter cake is cooled to about −30° C. 10. The method according to claim 1, wherein in step (f) extrudable filter cake mass contains residual moisture or organic solvent of about 40% by weight. 11. The method according to claim 1, wherein in step (h) the residual moisture content obtained is less than 1% by weight, so that a dried pancreatin product is produced with a residual moisture content of less than 1% by weight. 12. The method according to claim 1, wherein in step (h) the residual moisture content obtained is less than 0.5% by weight, so that a dried pancreatin product is produced with a residual moisture content of less than 0.5% by weight.