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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0795198 (2010-06-07) |
등록번호 | US-8691754 (2014-04-08) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 465 |
A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide.
A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide. The polyelectrolyte can include, e.g., BSA (Bovine Serum Albumin) which is bound to a functionalized surface using a covalent immobilization strategy, e.g., reaction with the surface of a tosyl-activated microparticle. Following such reaction, exposed reactive functional groups on the protein, such as amine, carboxyl, thiol, hydroxyl groups can further be utilized to covalently couple the oligonucleotide of interest using suitable chemistry.
1. A product comprising: a. A microparticle; andb. Bovine Serum Albumin (BSA) covalently attached to said microparticle, wherein said BSA comprises activated binding sites capable of forming a covalent bond with a primary amino group. 2. The product of claim 1, wherein said microparticle comprises a
1. A product comprising: a. A microparticle; andb. Bovine Serum Albumin (BSA) covalently attached to said microparticle, wherein said BSA comprises activated binding sites capable of forming a covalent bond with a primary amino group. 2. The product of claim 1, wherein said microparticle comprises a carboxy-functionalized surface. 3. The product of claim 1, wherein said microparticle comprises a tosyl-activated surface.
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