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Microparticles with enhanced covalent binding capacity and their uses

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-014/00
출원번호 US-0795198 (2010-06-07)
등록번호 US-8691754 (2014-04-08)
발명자 / 주소
  • Wang, Xinwen
  • Banerjee, Sukanta
출원인 / 주소
  • Bioarray Solutions, Ltd.
대리인 / 주소
    Womble Carlyle Sandridge & Rice, LLP
인용정보 피인용 횟수 : 0  인용 특허 : 465

초록

A polyelectrolyte having multiple exposed functional groups, each such group being capable of covalently bonding to a molecule, is immobilized on a surface for the purpose of bonding to a biomolecule. The biomolecule can be, for example, a nucleic acid, e.g., an amine functionalized oligonucleotide.

대표청구항

1. A product comprising: a. A microparticle; andb. Bovine Serum Albumin (BSA) covalently attached to said microparticle, wherein said BSA comprises activated binding sites capable of forming a covalent bond with a primary amino group. 2. The product of claim 1, wherein said microparticle comprises a

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  182. Weber James L. (Marshfield WI), Length polymorphisms in (dC-dA)nㆍ(dG-dT)n sequences.
  183. Nikiforov Theo (Baltimore MD) Karn Jonathan (Little Shelord GBX) Goelet Philip (Cockeysville MD), Ligase/polymerase mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis.
  184. Nikiforov Theo ; Karn Jonathan,GBX ; Goelet Philip, Ligase/polymerase-mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis.
  185. Michael Seul, Light-controlled electrokinetic assembly of particles near surfaces.
  186. Seul Michael, Light-controlled electrokinetic assembly of particles near surfaces.
  187. Seul, Michael, Light-controlled electrokinetic assembly of particles near surfaces.
  188. Seul, Michael, Light-controlled electrokinetic assembly of particles near surfaces.
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  190. Seul,Michael, Light-controlled electrokinetic assembly of particles near surfaces.
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  192. Huijuan D. Chen ; Tien-Teh Chen ; Kevin W. Williams, Loaded latex compositions with dye and stabilizer.
  193. Ledis Stephen L. (Hialeah FL) Crews Harold R. (Pembroke Pines FL) Fischer Timothy J. (Plantation FL) Sena Ted (Miami FL), Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples.
  194. Crews, Harold Richardson; Elliott, Michael N.; Carter, II, James Harrison, Lytic reagent composition for leukocyte differential analysis.
  195. Sasaki Motohiro,JPX ; Matsukawa Masahiko,JPX ; Yoshioka Katsuaki,JPX ; Anan Makoto,JPX ; Isomura Mitsuo,JPX ; Ashihara Yoshihiro,JPX ; Okada Masahisa,JPX, Magnetic particle and immunoassay using the same.
  196. Chang Manchium (4589 Via Marisol ; #265 Los Angeles CA 90042) Colvin Michael S. (25001 Pacific Coast Hwy. Malibu CA 90265), Magnetic particles.
  197. Josephson Lee (Arlington MA), Magnetic particles for use in separations.
  198. Daniel Jean-Claude (Fontenay/Sous/Bois FRX) Schuppiser Jean-Luc (Claye-Souilly FRX) Tricot ; deceased Marc (late of Andilly FRX by Nicole Tricot ; heir), Magnetic polymer latex and preparation process.
  199. Ugelstad John (Trondheim NOX) Ellingsen Turid (Trondheim NOX) Berge Arvid (Trondheim NOX) Helgee Oskar B. (Mlnlycke SEX), Magnetic polymer particles and process for the preparation thereof.
  200. Owen Charles S. (Swarthmore PA) Silvia John C. (Warminster PA) D\Angelo Louis (Berlin NJ) Liberti Paul A. (Churchville PA), Magnetic-polymer particles.
  201. Owen Charles S. ; Silvia John C. ; D'Angelo Louis ; Liberti Paul A., Magnetic-polymer particles.
  202. Wang Chao-Huei J. (Gurnee IL) Shah Dinesh Q. (Vernon Hills IL), Magnetically responsive fluorescent polymer particles.
  203. Charmot Dominique (Paris FRX) Vidil Christine (Paris FRX), Magnetizable composite microspheres of hydrophobic crosslinked polymer, process for preparing them and their application.
  204. Seul,Michael; Chau,Chiu Wo, Making a matrix of random encoded arrays.
  205. Wright Joseph D. (Burlington CAX), Marking material containing a taggant, and method of producing an image.
  206. Schumm James W. ; Bacher Jeffery W., Materials and methods for indentifying and analyzing intermediate tandem repeat DNA markers.
  207. Nova Michael P. ; Parandoosh Zahra ; Senyei Andrew E. ; Xiao Xiao-Yi ; David Gary S. ; Satoda Yozo ; Zhao Chanfeng ; Potash Hanan, Matrices with memories and uses thereof.
  208. Oja Tonis (Scarsdale NY) Petersen Gary L. (Kingstown RI) Cannon David W. (Attleboro Falls MA), Measurement of electro-kinetic properties of a solution.
  209. Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA), Mesoscale polynucleotide amplification device and method.
  210. Wilding Peter (Paoli PA) Kricka Larry J. (Berwyn PA), Mesoscale polynucleotide amplification devices.
  211. Brennan Thomas M. (San Francisco CA), Method and apparatus for conducting an array of chemical reactions on a support surface.
  212. Cole, Michael, Method and apparatus for determining temperature of and controlling the evaporation of liquid samples.
  213. Culkin Joseph B. (Wilton CT), Method and apparatus for determining the zeta potential of colloidal particles.
  214. Fulwyler Mack J. (Sunnyvale CA), Method and apparatus for distinguishing multiple subpopulations of cells.
  215. Mcbride Sterling Eduard ; Moroney ; III Richard Morgan, Method and apparatus for distributing fluid in a microfluidic device.
  216. Murakami Shingo,JPX, Method and apparatus for film formation by chemical vapor deposition.
  217. Farber Fredric (Brookline MA), Method and apparatus for magnetically separating biological particles from a mixture.
  218. Culkin Joseph B. (Wilton CT), Method and apparatus for measuring the unsteady sedimentation potential of colloidal particles.
  219. Herman ; deceased Joshua Randy ; Bergen James Russell ; Peleg Shmuel,ILX ; Paragano Vincent ; Dixon Douglas F. ; Burt Peter J. ; Sawhney Harpreet ; Gendel Gary A. ; Kumar Rakesh ; Brill Michael H., Method and apparatus for mosaic image construction.
  220. Dehlinger Peter J., Method and apparatus for producing position addressable combinatorial libraries.
  221. Becker Frederick F. ; Gascoyne Peter ; Wang Xiaobo ; Vykoukal Jody Valentine ; De Gasperis Giovanni,ITX, Method and apparatus for programmable fluidic processing.
  222. Hofmann Gunter A. (San Diego CA), Method and apparatus for separating particles in liquid suspension utilizing oscillating electric and magnetic fields.
  223. Lehnen Brian C. (San Carlos CA), Method and composition for the simultaneous and discrete analysis of multiple analytes.
  224. Malmqvist Magnus,SEX ; Roos H.ang.kan,SEX ; Sjolander Stefan,SEX ; Tidare Mattias,SEX ; Sjodin H.ang.kan,SEX ; St.ang.lberg Ralph,NOX, Method and device for laminar flow on a sensing surface.
  225. Stähler, Cord F.; Stähler, Peer F.; Müller, Manfred; Stähler, Fritz; Lindner, Hans, Method and device for producing biochemical reaction supporting materials.
  226. Vary Calvin P. H. (Califon NJ) Diamond Steven E. (Springfield NJ), Method and kit for polynucleotide assay including primer-dependant DNA polymerase.
  227. Stavrianopoulos Jannis G. (New York NY) Kirtikar Dollie (Elmhurst NY) Johnston Kenneth H. (New York NY) Thalenfeld Barbara E. (New York NY), Method and structures employing chemically-labelled polynucleotide probes.
  228. Southern Edwin Mellor,GBX ; Pritchard Clare Elizabeth,GBX ; Case-Green Stephen Charles,GBX, Method for analyzing a polynucleotide containing a variable sequence.
  229. Southern Edwin Mellor,GBX ; Pritchard Clare Elizabeth,GBX ; Case-Green Stephen Charles,GBX, Method for analyzing a polynucleotide containing a variable sequence and a set or array of oligonucleotides therefor.
  230. Margel Shlomo (Rehovot ILX), Method for attaching microspheres to a substrate.
  231. Leushner James,CAX ; Hui May,CAX ; Dunn James M.,CAX ; Larson Marina T. ; Lacroix Jean-Michel,CAX ; Shipman Robert,CAX, Method for bi-directional sequencing of nucleic acid polymers.
  232. Hamaguchi Yukio (Akashi JPX) Ito Kenji (Kakogawa JPX) Tsujino Yukio (Kobe JPX) Moriyama Kazuhiro (Yokohama JPX) Takenaka Ikuya (Mitaka JPX) Morikawa Takashi (Akashi JPX) Ohmi Hitomi (Akashi JPX), Method for classifying leukocytes and a reagent used therefor.
  233. Rubinstein Pablo ; Coelho Philip Henry ; Stevens Cladd E., Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulate.
  234. Goelet Philip ; Knapp Michael R. ; Anderson Stephen, Method for determining nucleotide identity through extension of immobilized primer.
  235. Trau Mathias ; Aksay Ilhan A. ; Saville Dudley A., Method for electrohydrodynamically assembling patterned colloidal structures.
  236. Brueck Steven R. J. (Albuquerque NM) Zaidi Saleem (Albuquerque NM) Chu An-Shyang (Albuquerque NM), Method for fine-line interferometric lithography.
  237. Heller Michael James ; Sosnowski Ronald George, Method for fingerprinting utilizing an electronically addressable array.
  238. Nikiforov Theo (San Diego CA) Knapp Michael R. (Baltimore MD), Method for immobilizing nucleic acid molecules.
  239. Lee, Jar-How; Pei, Rui, Method for immunobead flow cytometric detection of anti-HLA panel reactive antibody.
  240. Uematsu Hiroaki,JPX ; Daimon Katsuya,JPX ; Yoshiga Satoko,JPX, Method for isolating nucleic acids using silica-coated magnetic particles.
  241. Shannon Karen W., Method for linear mRNA amplification.
  242. Klainer Stanley M. (San Ramon CA) Walt David R. (Lexington MA) Gottlieb Amos J. (San Francisco CA 4), Method for making fluorescent polymers.
  243. David Schwartz, Method for mapping a nucleic acid.
  244. Kanayama Toshihiko (Tsukuba JPX), Method for producing minute particles and apparatus therefor.
  245. Willey James C. (Rochester NY), Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chai.
  246. Willey James C. (Rochester NY), Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chai.
  247. Wang Chang-Ning J. (Chelmsford MA) Wu Kai-Wuan (Lowell MA), Method for reducing non-specific priming in DNA amplification.
  248. Hillebrand Timo,DEX ; Bendzko Peter,DEX, Method for the simultaneous isolation of genomic DNA and high-purity RNA.
  249. Kawai Yoshio (3-12-10 Kichijoji-Higashicho Musashino-shi ; Tokyo JPX) Shirakami Toshiharu (3-41-11 Narusedai Machida-shi ; Tokyo JPX), Method of and apparatus for measuring electrophoretic mobility.
  250. Coster Hans (New South Wales AU) Pilwat Gunter (Julich DT) Zimmermann Ulrich (Julich DT), Method of and device for measuring elastic and di-electric properties of the diaphragm of living cells.
  251. Dorman Linneaus C. (Midland MI), Method of coupling a protein to a polymer particle containing hydrazide groups in a polymer latex and the products forme.
  252. Wallace R. Bruce, Method of detecting and discriminating between nucleic acid sequences.
  253. Fodor Stephen P.A. ; Solas Dennis W. ; Dower William J., Method of detecting nucleic acids.
  254. McArdle Ciaran B.,IEX ; Burke Joseph,IEX ; Welch ; II Edward K., Method of forming a monolayer of particles, and products formed thereby.
  255. Kobylecki Ryszard Jurek,GBX ; Gardner John Mark Francis,GBX, Method of making a library of compounds using a functionalized polymer support resin affixed to a laminar material.
  256. Jack James (Manningtree EN) Taylor-Brown Terence John (Ipswich EN), Method of making a retro-reflective beaded material.
  257. Chee,Mark S.; Stuelpnagel,John R.; Czarnik,Anthony W., Method of making and decoding of array sensors with microspheres.
  258. Walt David R. (Lexington MA) Barnard Steven M. (Medford MA), Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample.
  259. Asher Sanford A. (Pittsburgh PA) Jagannathan Sesh (Pittsburgh PA), Method of making solid crystalline narrow band radiation filter.
  260. Ershov Gennady Moiseevich,RUX ; Mirzabekov Andrei Darievich,RUX, Method of manufacturing a matrix for the detection of mismatches.
  261. Staub Rick ; Caskey Caroline, Method of newborn identification and tracking.
  262. Sutton Richard C. (Rochester NY) Ponticello Ignazio S. (Pittsford NY) Danielson Susan J. (Rochester NY) Oenick Marsha D. B. (Rochester NY), Method of preparing biologically active reagents from succinimide-containing polymers, analytical element and methods of.
  263. Schleifer Arthur ; Tom-Moy May, Method of producing oligonucleotide arrays with features of high purity.
  264. Prober James M. (Wilmington DE) Dam Rudy J. (Landenberg PA) Robertson ; Jr. Charles W. (Rockland DE) Hobbs ; Jr. Frank W. (Wilmington DE) Trainor George L. (Glen Mills PA), Method systems and reagents for DNA sequencing.
  265. Mark Chee, Method to detect gene polymorphisms and monitor allelic expression employing a probe array.
  266. Reeve Michael A. (Henley-on-Thames GB2), Method to isolate macromolecules using magnetically attractable beads which do not specifically bind the macromolecules.
  267. Wang Chaeo-Huej J. ; Shah Dinesh O., Method to use fluorescent magnetic polymer particles as markers in an immunoassay.
  268. Yuri C. Gaidoukevitch NL; Kevin W. Ryan ; Dean E. Sequera, Method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay.
  269. Cargill John ; Armstrong Robert W., Methods and apparatus for synthesizing labeled combinatorial chemistrylibraries.
  270. John N. Vournakis ; Arun K. Seth CA; Takis S. Papas, Methods and compositions for diagnosis and treatment of breast cancer.
  271. Gordon Gary B. ; Dellinger Douglas J., Methods and devices for carrying out chemical reactions.
  272. Zailin Yu ; Zaoyuan Peng ; Qianjin Hu, Methods for amplifying and detecting multiple polynucleotides on a solid phase support.
  273. Fulcrand Geraldine ; Dellinger Douglas J. ; Lefkowitz Steven M., Methods for attaching substances to surfaces.
  274. Gildea Brian D. ; Coull James M., Methods for automated synthesis of PNA-DNA chimeras and compositions thereof.
  275. Backus John W. (Williamson NY) Ekeze Tobias E. (Rochester NY) Swartz Jerome C. (Rochester NY) Sutton Richard C. (Rochester NY) Ponticello Ignazio S. (Pittsford NY) Kerschner JoAnne H. (Rochester NY) , Methods for capture and selective release of nucleic acids using weakly basic polymer and amplification of same.
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  277. Francois J.-M. Iris FR; Jean-Louis Pourny FR, Methods for detection of nucleic acid polymorphisms using peptide-labeled oligonucleotides and antibody arrays.
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  280. Heller Michael J., Methods for electronic stringency control for molecular biological analysis and diagnostics.
  281. Ackley Donald E. ; LeClair Timothy L. ; Swanson Paul D., Methods for fabricating multi-component devices for molecular biological analysis and diagnostics.
  282. Rosen, Hugo R., Methods for identifying a preferred liver transplant donor.
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  285. Brenner Sydney (Cambridge GB2), Methods for sorting polynucleotides using oligonucleotide tags.
  286. Shuber Anthony P. ; Lapidus Stanley N. ; Daley George Q., Methods for the detection of nucleic acids.
  287. Liberti Paul A. (Huntingdon Valley PA) Rao Galla C. (Princeton NJ) Chiarappa Joseph N. (Flemington NJ), Methods for the manufacture of magnetically responsive particles.
  288. Khrapko Konstantin R. (Moscow RUX) Khorlin Alexandr A. (Moscow RUX) Ivanov Igor B. (Moskovskaya RUX) Ershov Gennady M. (Moscow RUX) Lysov Jury P. (Moscow RUX) Florentiev Vladimir L. (Moscow RUX) Mirz, Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device.
  289. Smith Craig E. ; York Charles K., Methods of isolating biological target materials using silica magnetic particles.
  290. Cheung Sau W. (8528 Douglas Ct. St. Louis MO 63144), Methods of making fluorescent microspheres.
  291. Akhavan-Tafti Hashem, Methods of synthesizing labeled polynucleotides by ligation of multiple oligomers.
  292. Gentalen Erik ; Chee Mark, Methods of using an array of pooled probes in genetic analysis.
  293. Yang,Jiacheng, Methods of using molecular constructs for detection of biochemical reactions.
  294. Kocher, Thomas E., Micro-array calibration means.
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  296. Hozier John (8950 S. Tropical Trail Merritt Island FL 32952), Micro-libraries and methods of making and manipulating them methods for generating and analyzing micro-libraries.
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  299. Sammak, Paul; Rosania, Gustavo; Zana, Lawrence J.; Ippolito, Kim; Bush, Jason; Friedman, Alex; Tencza, Sarah Burroughs; Kapur, Ravi, Microbead-based test plates and test methods for fluorescence imaging systems.
  300. Huang,Mingxian; Wu,Lei; Wang,Xiaobo; Xu,Junquan; Tao,Guo Liang; Rothwarf,David M., Microdevices having a preferential axis of magnetization and uses thereof.
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  302. Goetz Philip J. (Pleasantville NY), Microelectrophoresis apparatus.
  303. Spence, Charles F.; Fu, Anne Y.; Quake, Stephen R.; Arnold, Frances H., Microfabricated cell sorter for chemical and biological materials.
  304. Jacobson Stephen C. ; Ramsey J. Michael, Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same.
  305. David J. Beebe ; Jeffrey S. Moore, Microfabricated devices and method of manufacturing the same.
  306. Yager Paul ; Weigl Bernhard H. ; Brody James P ; Holl Mark R., Microfabricated diffusion-based chemical sensor.
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  308. Frazier A. Bruno ; Caldwell Karin D.,SEX ; Gale Bruce K., Micromachined electrical field-flow fractionation system.
  309. Chandler Mark B. ; Chandler Don J., Microparticles attached to nanoparticles labeled with flourescent dye.
  310. Ottoboni Thomas B. ; Short Robert E. ; Yamamoto Ronald K., Microparticles useful as ultrasonic contrast agents.
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  316. Becker, Michael M.; Schroth, Gary P., Molecular torches.
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  320. Wohlstadter Jacob N. ; Wilbur James ; Sigal George ; Martin Mark ; Guo Liang-Hong ; Fischer Alan ; Leland Jon ; Billadeau Mark A., Multi-array, multi-specific electrochemiluminescence testing.
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  324. Ackley Donald E. ; LeClair Timothy L. ; Swanson Paul D., Multicomponent devices for molecular biological analysis and diagnostics.
  325. Vo-Dinh, Tuan, Multifunctional and multispectral biosensor devices and methods of use.
  326. Kauvar, Lawrence M.; Sedat, John, Multihued labels.
  327. Dutertre Bernard (Neuilly sur Seine FRX), Multiple electrophoresis method for the controlled migration of macromolecules through rectangular gel plates.
  328. Bowser Everett N. (715 N. Main St. Glen Ellyn IL 60137), Multiple test tube evaporator.
  329. Henrickson Kelly J. ; Fan Jiang, Multiplex PCR assay using unequal primer concentrations to detect HPIV 1,2,3 and RSV A,B and influenza virus A, B.
  330. Schumm James W. ; Micka Katherine A. ; Rabbach Dawn R., Multiplex amplification of short tandem repeat loci.
  331. Schumm James W. ; Sprecher Cynthia J. ; Lins Ann M., Multiplex amplification of short tandem repeat loci.
  332. Watkins Michael I. ; Edwards Richard B., Multiplex flow assays preferably with magnetic particles as solid phase.
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  334. Kovacs Gregory T. A., Multiplexed active biologic array.
  335. Chandler Van S. ; Fulton R. Jerrold ; Chandler Mark B., Multiplexed analysis of clinical specimens apparatus and methods.
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  337. Balch William J., Multiplexed molecular analysis apparatus and method.
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  357. Kiel Johnathan L. ; Bruno John G. ; Parker Jill E. ; Alls John L. ; Batishko Charles R. ; Holwitt Eric A., Organic semiconductor recognition complex and system.
  358. Michael P. Strathmann, Parallel methods for genomic analysis.
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  360. Pease John (Los Altos CA) Weng Litai (Mountain View CA) Kirakossian Hrair (San Jose CA) Ullman Edwin F. (Atherton CA), Particle with luminescer for assays.
  361. Rigopulos Peter N. (Boxford MA) Desaulniers Charles W. (Franklin MA) Doucette David E. (Wakefield MA), Particulate support material.
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  385. Kata Keiichiro,JPX ; Chikaki Shinichi,JPX, Process for manufacturing semiconductor device and semiconductor wafer.
  386. Okubo Masayoshi (Kobe JPX) Tsujihiro Masami (Osaka JPX), Process for preparation of monodisperse polymer particles having increased particle size.
  387. Ugelstad John (Trondheim NOX), Process for preparing an aqueous emulsion or dispersion of a partly water-soluble material, and optionally further conve.
  388. Ugelstad John (Trondheim NOX) Ellingsen Turid (Trondheim NOX) Berge Arvid (Trondheim NOX) Helgee Oskar B. (Mnlycke SEX), Process for preparing magnetic polymer particles.
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  391. Matijevic Egon (Potsdam NY), Process for synthesis of uniform colloidal particles of rare earth oxides.
  392. Tricot Marc (Andilly FRX) Daniel Jean-Claude (Fontenay sous Bois FRX), Process for the preparation of magnetic beads of vinylaromatic polymers.
  393. Margel Shlomo,ILX ; Bamnolker Hanna,ILX, Process for the preparation of microspheres and microspheres made thereby.
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  395. Chen, Tsang J., Processes for achieving uniform, efficient distribution of hydrophobic materials through hydrophilic colloid layers and loaded latex compositions.
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  397. Azegami Kengo (Kawasaki JPX) Yamashita Koichi (Kawasaki JPX), Programmable logic circuit.
  398. Peter Wagner ; Dana Ault-Riche ; Steffen Nock ; Christian Itin, Protein arrays for high-throughput screening.
  399. Rembaum Alan (Altadena CA), Protein specific fluorescent microspheres for labelling a protein.
  400. Walt David R. (Lexington MA), Radiative and non-radiative energy transfer and absorbance modulated fluorescence detection methods and sensors.
  401. Lam Kit Sang (Tucson AZ) Salmon Sydney E. (Tucson AZ), Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof.
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  406. Wang Mark S. ; Li Limin, Rapid screening assay methods and devices.
  407. Nacamulli Laurette (Rockville MD) Leland Jonathan K. (Silver Spring MD) Hayes Stephanie A. (Gaithersburg MD), Rate measurements of biomolecular reactions using electrochemiluminescence.
  408. Hashmi,Ghazala; Seul,Michael; Messing,Joachim, Real-time monitoring of nucleic acid target-identifying signals.
  409. Berry James A. ; Dolezal William E. ; Sayers Adda C., Remote imaging system for plant diagnosis.
  410. Nova Michael P. ; Senyei Andrew E., Remotely programmable matrices with memories.
  411. Tang JianQing,CAX ; Melan.cedilla.on Serge B.,CAX, STR marker system for DNA fingerprinting.
  412. Fiekowsky Peter ; Bartell Dan M., Scanned image alignment systems and methods.
  413. Hirth Klaus Peter ; App Harald ; Tsai Jianming, Screening assays for compounds.
  414. Jain Kanti ; Dunn Thomas J. ; Hoffman Jeffrey M, Seamless, maskless lithography system using spatial light modulator.
  415. Walt,David R.; Dickinson,Todd A., Self-encoding fiber optic sensor.
  416. Pope Edward J. A. (447 Lorenzo Dr. Agoura CA 91301), Sensor incorporating an optical fiber and a solid porous inorganic microsphere.
  417. Muller-Schulte, Detlef, Separating, detecting or quantifying biological materials using magnetic cross-linked polyvinyl alcohol particles.
  418. Gombinski Moshe,ILX, Separation by magnetic particles.
  419. Bader Joel S. ; Rothberg Jonathan M. ; Deem Michael W. ; Mulhern Gregory T. ; Went Gregory T. ; Simpson John ; Henck Steven, Separation of charged particles by a spatially and temporally varying electric field.
  420. Mercolino, Thomas J.; Reis, Kathleen J., Simultaneous determination of forward and reverse ABO blood group.
  421. Vyas Girish N. ; Venkateswaran Kodumudi, Simultaneous human ABO and RH(D) blood typing or antibody screening by flow cytometry.
  422. Brenner Sydney,GB2, Simultaneous sequencing of tagged polynucleotides.
  423. Singer Robert H. ; Femino Andrea M., Single molecule detection by in situ hybridization.
  424. Scott Marion Lesley,GB3, Solid phase immunological assay.
  425. Hamper Bruce C., Solid phase organic synthesis device with pressure-regulated manifold.
  426. Van Ness Jeffrey (Bothell WA) Petrie Charles R. (Woodinville WA) Tabone John C. (Bothell WA) Vermeulen Nicolaas M. J. (Woodinville WA), Solid supports for nucleic acid hybridization assays.
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  430. Ackley Donald E. ; Sheldon Edward L. ; Krihak Michael K., Stacked, reconfigurable system for electrophoretic transport of charged materials.
  431. Inoguchi Kazutaka,JPX ; Nose Hiroyasu,JPX ; Morishima Hideki,JPX, Stereoscopic image display apparatus using specific mask pattern.
  432. Goldberg Martin ; Diggelman Martin,CHX ; Hubbell Earl ; McGall Glenn ; Ngo Nam Quoc ; Morris Macdonald ; Yamamoto Mel ; Tan Jennifer ; Rava Richard P., Substrate preparation process.
  433. Mao Fei ; Leung Wai-Yee ; Haugland Richard P., Sulfonated xanthene derivatives.
  434. Walt David R. (Lexington MA) Pantano Paul (Everett MA), Superresolution imaging fiber for subwavelength light energy generation and near-field optical microscopy.
  435. St채hler,Cord F.; St채hler,Peer F.; M체ller,Manfred; St채hler,Fritz; Lindner,Hans, Support for a method for determining an analyte and a method for producing the support.
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  437. Rao Galla Chandra (Princeton NJ) Liberti Paul A. (Huntingdon Valley PA), Surface immobilization of magnetically collected materials.
  438. Wang, Xinwen; Banerjee, Sukanta, Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules.
  439. Klainer Stanley M. (San Ramon CA) Walt David R. (Lexington MA) Gottlieb Amos J. (San Francisco CA), Surface-bound fluorescent polymers and related methods of synthesis and use.
  440. Lockhart David J. (Santa Clara CA) Vetter Dirk (Freiburg DEX) Diggelmann Martin (Niederdorf CHX), Surface-bound, unimolecular, double-stranded DNA.
  441. Wischerhoff,Erik, Surfaces comprising a hydrophilic spacer, covalently bonded to hydrogels.
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  445. Seul,Michael; Chau,Chiu Wo, System and method for programmable illumination pattern generation.
  446. Seul,Michael; Chau,Chiu Wo, System and method for programmable illumination pattern generation.
  447. Szeliski,Richard S.; Wilt,Nicholas P., System and method for statistically comparing and matching plural sets of digital data.
  448. Dunlay R. Terry ; Taylor D. Lansing, System for cell-based screening.
  449. Sussman Michael, System for obtaining a uniform illumination reflectance image during periodic structured illumination.
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  451. Ravkin, Ilya; Goldbard, Simon; Hyun, William C.; Zarowitz, Michael A., Systems and methods of conducting multiplexed experiments.
  452. Southern Edwin,GBX ; Cummins William Jonathan,GBX, Tag reagent and assay method.
  453. Southern Edwin,GBX ; Cummins William Jonathan,GBX, Tag reagent and assay method.
  454. Dower William J. ; Barrett Ronald W. ; Gallop Mark A. ; Needels Michael C., Tagged synthetic oligomer libraries.
  455. Walt David R. ; Michael Karri L., Target analyte sensors utilizing Microspheres.
  456. Ghandour,Ghassan, Techniques for identifying confirming mapping and categorizing nucleic acids.
  457. Schulz Donald N. (Annandale NJ) Berluche Enock (Phillipsburg NJ) Maurer John J. (New Providence NJ) Bock Jan (Bridgewater NJ), Tetrapolymers of N-vinyl pyrrolidone/acrylamide/salt of acrylic acid/N-alkyl acrylamide.
  458. Walt David R. (Lexington MA) Bronk Karen S. (Somerville MA), Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample.
  459. McGuire Kenneth Stephen ; Tweddell ; III Richard ; Hamilton Peter Worthington, Three-dimensional, amorphous-patterned, nesting-resistant sheet materials and method and apparatus for making same.
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  462. Smith, Martin A.; Fomovskaia, Galina N.; Fomovsky, Mikhail A.; Butt, Neil J.; Baker, Matthew, Transfusion medicine leukodepletion filter devices as a source of genetic material for genotyping studies.
  463. Anne R. Kopf-Sill ; Andrea W. Chow ; Peter C. Jann ; Morten J. Jensen ; Michael Spaid ; Colin B. Kennedy ; Michael J. Kennedy, Ultra high throughput microfluidic analytical systems and methods.
  464. Zarling David A. (Menlo Park CA) Rossi Michel J. (Lausanne CHX) Peppers Norman A. (Belmont CA) Kane James (Lawrenceville NJ) Faris Gregory W. (Menlo Park CA) Dyer Mark J. (San Jose CA) Ng Steve Y. (S, Up-converting reporters for biological and other assays using laser excitation techniques.
  465. McCasky Feazel Rhonda J. ; Helentjaris Timothy G. ; Malmberg Sharon E. ; Martin Barry A., Use of selective DNA fragment amplification products for hybridization-based genetic fingerprinting, marker assisted selection, and high-throughput screening.

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