초록 ▼

A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is inte

A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is intended to keep liquid contents under vigorous agitation in the container without wetting the gas-permeable barrier. The adaptor couples the closure to the container in a secure fashion. The bellows element allows for repeated changes in the internal volume of the container-closure system. The gas-permeable barrier allows desired gases to enter and leave the container while excluding small particles and/or microorganisms. The technology may be used with existing glass flask technology, or coupled to a plastic flask that may be configured for either single-use, or multiple-use.

대표청구항 ▼

1. A closure for a container comprising a body and a neck with a tubular opening and an outer surface, said body being adapted to hold a fluid during a mixing operation that involves movement of said container, said closure comprising: a sleeve comprising a flexible portion having a plurality of ann

1. A closure for a container comprising a body and a neck with a tubular opening and an outer surface, said body being adapted to hold a fluid during a mixing operation that involves movement of said container, said closure comprising: a sleeve comprising a flexible portion having a plurality of annular corrugations therein, a top end having a vent therein, a bottom end and a longitudinal axis, said flexible portion being operative to flex during the mixing operation;an adaptor that is operative to attach said bottom end to said tubular opening, said adaptor having an axially-oriented passageway therethrough that is in communication with and open to said bottom end and the container, said axially-oriented passageway having an interior surface;a filter that is attachable to said top end and that is operative to cover said vent, allow gases to enter and leave said container and prevent microorganisms from entering and leaving said container, anda splashguard that is attached to said adaptor and that is operative to prevent the fluid from entering said adaptor during the mixing operation, said splashguard comprising a main body, an upper droplet shield that is attached to said main body and that is disposed above said axially-oriented passageway, a lower droplet shield that is attached to said main body and that is disposed below said axially-oriented passageway and a plurality of panels that are attached to said main body and that are disposed substantially within said axially-oriented passageway, each of said panels having an edge that abuts said interior surface;wherein the flexing of said flexible portion is operative to cause said gases to move through said filter and in and out of the container. 2. The closure of claim 1 wherein said sleeve, adaptor, filter and said splashguard are autoclavable. 3. The closure of claim 1 I wherein said adaptor comprises a deformable insert that has a frustoconical shape. 4. The closure of claim 1 wherein said adaptor comprises a tubular sidewall having inwardly-projecting, circumferentially-spaced fingers that are adapted to grip the outer surface of the neck of the container. 5. The closure of claim 1 wherein said adaptor comprises a tubular sidewall having indentations and inwardly- projecting threads that are adapted to screw onto threads on the outer surface of the neck of the container. 6. The closure of claim 1 wherein said flexible portion is fabricated from a biocompatible material. 7. The closure of claim 6 wherein said biocompatible material is silicone rubber. 8. A closure for a container comprising a body and a neck with a tubular opening and an outer surface, said body being adapted to hold a fluid during a mixing operation that involves vertical movement of said container, said closure comprising: a sleeve comprising a flexible portion having annular corrugations therein, a top end having a vent therein and a tubular bottom end, said flexible portion being operative to flex during the mixing operation;an adaptor that is operative to attach said tubular bottom end to said tubular opening;a filter that is attachable to said top end and that is operative to cover said vent, allow gases to enter and leave said container and prevent microorganisms from entering and leaving said container; anda splashguard that is attached to said tubular bottom end and that is operative to prevent the fluid from entering said tubular bottom end during the mixing operation;wherein the flexing of said flexible portion is operative to cause said gases to move through said filter and in and out of the container during the vertical movement of the container;wherein said flexible portion comprises stiffeners and is operative to rock from side to side during the mixing operation. 9. The closure of claim 8 wherein said flexible portion comprises an embedded spring. 10. The closure of claim 8 wherein said filter is operative to prevent selected gases from entering or leaving said container. 11. The closure of claim 8 wherein said filter is a membrane filter. 12. The closure of claim 8 wherein said filter is a high efficiency particulate air filter. 13. A closure for a container comprising a body and a neck with a tubular opening and an outer surface, said body being adapted to hold a fluid during a mixing operation that involves vertical movement of said container, said closure comprising: a sleeve comprising a flexible portion having annular corrugations therein, a top end having a vent therein and a tubular bottom end, said flexible portion being operative to flex during the mixing operation;a cap that attaches said filter to said top end and that prevents said filter from flexing;an adaptor that is operative to attach said tubular bottom end to said tubular opening;a filter that is attachable to said top end and that is operative to cover said vent, allow gases to enter and leave said container and prevent microorganisms from entering and leaving said container, anda splashguard that is attached to said tubular bottom end and that is operative to prevent the fluid from entering said tubular bottom end during the mixing operation;wherein the flexing of said flexible portion is operative to cause said gases to move through said filter and in and out of the container during the vertical movement of the container:,wherein said cap is rotatable with respect to said top end and has an opening in it that is operative to uncover at a least a portion of said filter when said cap is rotated to a desired position. 14. The closure of claim 13 wherein said splashguard has a shape that is selected from the group consisting of: a cone, an inverted cone, a frustum of a cone and a disc. 15. The closure of claim 13 wherein said splashguard has one or more drain holes. 16. The closure of claim 13 wherein said splashguard has a non-stick surface. 17. A closure for a container comprising a body and a neck with a tubular opening and an outer surface, said body being adapted to hold a fluid during a mixing operation that involves vertical movement of said container, said closure comprising: a sleeve comprising a flexible portion having annular corrugations therein, a top end having a vent therein and a tubular bottom end, said flexible portion being operative to flex during the mixing operation;an adaptor that is operative to attach said tubular bottom end to said tubular opening;a humidifier,a filter that is attachable to said top end and that is operative to cover said vent, allow gases to enter and leave said container and prevent microorganisms from entering and leaving said container; anda splashguard that is attached to said tubular bottom end and that is operative to prevent the fluid from entering said tubular bottom end during the mixing operation;wherein the flexing of said flexible portion is operative to cause said gases to move through said filter and in and out of the container during the vertical movement of the container. 18. The closure of claim 17 further comprising a sampling port. 19. A closure for a container comprising a body and a neck with a tubular opening and an outer surface said body being adapted to hold a fluid during a mixing operation that involves vertical movement of said container, said closure comprising: a sleeve comprising a flexible portion having annular corrugations therein, a top end having a vent therein and a tubular bottom end, said flexible portion being operative to flex during the mixing operation;an adaptor that is operative to attach said tubular bottom end to said tubular opening;a filter that is attachable to said top end and that is operative to cover said vent, allow gases to enter and leave said container and prevent microorganisms from entering and leaving said container; anda splashguard that is attached to said tubular bottom end and that is operative to prevent the fluid from entering said tubular bottom end during the mixing operation;wherein the flexing of said flexible portion is operative to cause said gases to move through said filter and in and out of the container during the vertical movement of the container;wherein said splashguard comprises a main body, an upper droplet shield that is attached to said main body, a lower droplet shield that is attached to said main body and a plurality of panels that are attached to said main body. 20. A method for enhancing gas movement into and out of an opening in a container having contents, said method comprising: attaching a bellows to said opening to produce a combination, said bellows having a volume, a splashguard and a vent that is covered by a filter through which particles of a selected size cannot pass; andmoving said combination in an oscillating motion or an orbital motion to cause said volume to increase and then decrease in a cyclic manner;wherein said moving step is accomplished by exposing said bellows to a magnetic field. 21. A method for enhancing gas movement into and out of an opening in a container having contents, said method comprising: attaching a bellows to said opening to produce a combination, said bellows having a volume, a splashguard and a vent that is covered by a filter through which particles of a selected size cannot pass; andmoving said combination in an oscillating motion or an orbital motion to cause said volume to increase and then decrease in a cyclic manner;wherein said moving step is accomplished by attaching said bellows to an externally activated mechanical member. 22. The method of claim 21 further comprising: monitoring a characteristic of said contents during the moving step. 23. A closure for a container comprising a body and a neck with an opening and an outer surface, said body being adapted to hold a fluid during a mixing operation that involves movement of said container, said closure comprising: a sleeve comprising a flexible portion having at least one annular corrugation therein, a first end having a vent therein and a second end, said flexible portion being operative to flex during the mixing operation;an adaptor that is operative to attach said second end to said opening;a filter that is attachable to said first end and that is operative to cover said vent, allow gases to enter and leave said container and prevent microorganisms from entering and leaving said container, anda splashguard that is attached to said second end and that is operative to prevent the fluid from reaching said filter during the mixing operation;wherein the flexing of said flexible portion is operative to cause said gases to move through said filter and in and out of the container;wherein said splashguard comprises a main body, an upper droplet shield that is attached to said main body, a lower droplet shield that is attached to said main body and a plurality of panels that are attached to said main body. 24. The closure of claim 23 wherein said splashguard has a height to diameter ratio in the range of about 0.13 to 0.20. 25. The closure of claim 23 wherein each of said droplet shields has a cone angle of 90.5 to 104 degrees. 26. The closure of claim 23 wherein each of said droplet shields has a flat plate inclination angle of 80 degrees to 90 degrees.