IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0767229
(2007-06-22)
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등록번호 |
US-8702751
(2014-04-22)
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발명자
/ 주소 |
|
출원인 / 주소 |
- Advanced Medical Solutions (Plymouth) Limited
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
48 |
초록
▼
An adhesive applicator for applying medical adhesives, particularly cyanoacrylates, to incisions such as those made during minimally invasive surgery. The applicator employs a pipette tip or similar narrow flow restrictor tip to close the incision and a body of foam to seal the incision. Methods of
An adhesive applicator for applying medical adhesives, particularly cyanoacrylates, to incisions such as those made during minimally invasive surgery. The applicator employs a pipette tip or similar narrow flow restrictor tip to close the incision and a body of foam to seal the incision. Methods of using the applicator are also disclosed.
대표청구항
▼
1. An applicator for controllably releasing and applying a surgical adhesive to an incision comprising a receiver having a deformable cylindrical body, the body having a deformable cylindrical wall and a cylinder-closing first end and an open second end, the internal dimensions of the receiver being
1. An applicator for controllably releasing and applying a surgical adhesive to an incision comprising a receiver having a deformable cylindrical body, the body having a deformable cylindrical wall and a cylinder-closing first end and an open second end, the internal dimensions of the receiver being set to accommodate and receive a sealed ampoule of surgical adhesive, the ampoule being formed of a frangible material which when fractured releases the surgical adhesive,the second open end being cylindrical with a series of circumferential sealing ribs present on the outer surface of the second open end,a blunt cylindrical body of a surgical adhesive-permeable foam material inserted into the open second end of the receiver to absorb and transmit adhesive released from the ampoule,a cylindrical collar having an open first end and an open second end,the first end of the collar having an internal diameter selected to sealably engage the circumferential sealing ribs, the collar enclosing the body of foam material,and the second end of the collar having an internal diameter selected to provide a narrowed pathway for the released adhesive to pass when the collar is sealed to the second end of the receiver,a latching slot in the outer surface of the second end of the receiver, the latching slot located adjacent to the circumferential sealing ribs but being between the circumferential sealing ribs and the first end,and the collar having an internally-projecting locking key which fits into the locking slot and locks the collar onto the receiver when the collar is rotated on a common axis between the collar and the receiver. 2. The applicator of claim 1, additionally comprising a flow restrictor frictionally attached to the second end of the collar through which surgical adhesive can pass. 3. The applicator of claim 2, wherein the flow restrictor is a pipette tip. 4. The applicator of any of claim 1, 2, or 3 additionally comprising at least one pressure barb positioned to apply an ampoule-fracturing force to the sealed ampoule. 5. The applicator of claim 4 additionally comprising at least one pressure pad positioned to apply an adhesive-expressing pressure to the fractured ampoule. 6. The applicator of any of claim 1, 2, or 3 additionally comprising a pair of wings, each having an inside and an outside end with the inside end affixed to the receiver at a position adjacent to the open end with the two wings being positioned diametrically across the cylindrical body, with the outside end of the wings being splayed out away from the cylindrical wall but being movable toward the cylindrical wall when a user applies opposing-finger pressure to the outside ends,each of the wings having a pressure barb facing toward the cylindrical wall, the pressure barb bearing upon the cylindrical wall and capable of applying a compressing force to the cylindrical wall, which compressing force distorts the cylindrical wall of the cylindrical body and applies a fracturing force to an ampoule accommodated and received within the receiver, the fracturing force releasing surgical adhesive contained within the ampoule. 7. The applicator of claim 6 wherein each of the wings additionally comprises a pressure pad facing toward the cylindrical wall, the pressure pad bearing upon the cylindrical wall and capable of applying an adhesive-expressing compressing force to the cylindrical wall, which adhesive-expressing compressing force distorts the cylindrical wall of the cylindrical body and applies an adhesive expressing force to the ampoule, the adhesive-expressing force expressing surgical adhesive contained within the ampoule out of the applicator. 8. The applicator according to claim 1, wherein the surgical adhesive comprises a cyanoacrylate ester, in monomeric form, represented formula I: where R is selected from the group consisting of: alkyl of 1 to 10 carbon atoms,alkenyl of 2 to 10 carbon atoms,cycloalkyl groups of from 5 to 8 carbon atoms,phenyl,2-ethoxyethyl,3-methoxybutyl, and a substituent of the formula: wherein each R′ is independently selected from the group consisting of: hydrogen and methyl, andR″ is selected from the group consisting of: alkyl of from 1 to 6 carbon atoms,alkenyl of from 2 to 6 carbon atoms,alkynyl of from 2 to 6 carbon atoms,cycloalkyl of from 3 to 8 carbon atoms,aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,phenyl, andphenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, of alkyl 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms. 9. The applicator of claim 8, wherein the surgical adhesive further comprises an antimicrobial agent. 10. An applicator for controllably releasing and applying a surgical adhesive to an incision comprising a receiver having a deformable cylindrical body, the body having a deformable cylindrical wall and a cylinder-closing first end and an open second end, the internal dimensions of the receiver being set to accommodate and receive a sealed ampoule of surgical adhesive, the ampoule being formed of a frangible material,the second open end being cylindrical with a series of circumferential sealing ribs present on the outer surface of the second open end and a latching slot in the outer surface of the second end, the latching slot located proximal to the collar and adjacent to the circumferential sealing ribs but being between the circumferential sealing ribs and the first end,a pair of wings, each having an inside and an outside end with the inside end affixed to the receiver at a position adjacent to the open end with the two wings being positioned diametrically across the cylindrical body, with the outside end of the wings being splayed out away from the cylindrical wall but being movable toward the cylindrical wall when a user applies opposing finger pressure to the outside ends,each of the wings having a pressure barb facing toward the cylindrical wall, the pressure barb bearing upon the cylindrical wall and capable of applying a compressing force to the cylindrical wall, which compressing force distorts the cylindrical wall of the cylindrical body and applies a fracturing force to an ampoule accommodated and received within the receiver, the fracturing force releasing surgical adhesive contained within the ampoule,a blunt cylindrical body of surgical adhesive-permeable foam inserted into the open second end of the receiver to absorb and transmit adhesive released from the ampoule,a cylindrical collar having an open first end and an open second end, the first end having an internal diameter selected to sealably engage the circumferential sealing ribs and having an internally-projecting locking key which fits into the locking slot and locks the collar onto the receiver when the collar is rotated on a common axis between the collar and the receiver, the collar enclosing the body of foam,and the second end having an internal diameter selected to provide a narrowed pathway for the adhesive to pass when the collar is sealed to the second end of the receiver,and the second end of the collar having a slightly tapered cylindrical shape sized to frictionally and sealably engage a pipette tip,the pipette tip, when sealed to the collar providing a sealed narrow pathway for surgical adhesive to pass from the receiver through the pipette tip and the collar, when removed, providing a broader pathway for the adhesive to pass as a sealing layer from the receiver through the body of foam to the incision. 11. A method of closing and sealing an incision with an adhesive applicator comprising obtaining the applicator of claim 10 with the sealed ampoule of surgical adhesive contained in the receiver,applying a squeezing-together pressure to the wings to produce a compressing force to the cylindrical wall, which compressing force distorts the cylindrical wall of the cylindrical body and applies a fracturing force to the ampoule, the fracturing force releasing the surgical adhesive contained within the ampoule, the adhesive passing through the adhesive-permeable foam through the cylindrical collar and through the pipette tip to form the small drops of adhesive,closing the incision by applying the small drops of adhesive from the applicator to the incision;removing the pipette tip to provide a tip-free applicator,sealing the incision by applying a line of adhesive from the tip-free applicator to the incision through the body of adhesive-permeable foam. 12. The method of claim 11, wherein the incision is a incision made during laparoscopic surgery. 13. The method of claim 11, wherein the surgical adhesive comprises a cyanoacrylate ester, in monomeric form, represented formula I: where R is selected from the group consisting of: alkyl of 1 to 10 carbon atoms,alkenyl of 2 to 10 carbon atoms,cycloalkyl groups of from 5 to 8 carbon atoms,phenyl,2-ethoxyethyl,3-methoxybutyl,and a substituent of the formula: wherein each R′ is independently selected from the group consisting of: hydrogen and methyl, andR″ is selected from the group consisting of: alkyl of from 1 to 6 carbon atoms,alkenyl of from 2 to 6 carbon atoms,alkynyl of from 2 to 6 carbon atoms,cycloalkyl of from 3 to 8 carbon atoms,aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,phenyl, andphenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, of alkyl 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms. 14. The applicator of claim 11, wherein the surgical adhesive further comprises an antimicrobial agent.
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