초록 ▼

An orthopaedic screw having a plurality of regions, at least one of which may be porous. The orthopaedic screw includes a head, a tip and at least one thread. The porosity of the screw of the present invention can vary within the part or region, including changes in pore shape, size and density. The

An orthopaedic screw having a plurality of regions, at least one of which may be porous. The orthopaedic screw includes a head, a tip and at least one thread. The porosity of the screw of the present invention can vary within the part or region, including changes in pore shape, size and density. These characteristics can vary along the length of the screw axis and/or radially (from the outer diameter to the axis). The orthopaedic screw may further include at least one solid region formed of any implantable polymer, reinforced polymer or metal.

대표청구항 ▼

1. A method of localized delivery of a therapeutic agent to surrounding tissue, the method comprising: providing a therapeutic agent;providing a screw having a reservoir and a plurality of porous bands in fluid connection with said reservoir and extending from said reservoir to an outside surface of

1. A method of localized delivery of a therapeutic agent to surrounding tissue, the method comprising: providing a therapeutic agent;providing a screw having a reservoir and a plurality of porous bands in fluid connection with said reservoir and extending from said reservoir to an outside surface of the screw, said plurality of porous bands being separated by at least one non-porous region of the screw;positioning said screw at a predetermined location in the body of a patient; anddelivering a predetermined amount of said therapeutic agent from said reservoir through said plurality of porous bands to said surrounding soft tissue. 2. The method according to claim 1, wherein said therapeutic agent is pre-loaded in said screw. 3. The method according to claim 1, wherein said therapeutic agent is loaded into said screw one of before, during and after a surgery. 4. The method according to claim 3, further comprising the step of providing one of a self-sealing polymer diaphragm and a removable cap for direct interface with a needle for loading said therapeutic agent into said screw. 5. The method according to claim 1, wherein said therapeutic agent is one of hydroxyapetit, drugs and biologics. 6. The method according to claim 1, further comprising the step of providing a marker for indicating position and orientation of said screw in said body of said patient. 7. The method according to claim 1, further comprising the step of providing a port and a catheter, wherein said screw is configured to receive said therapeutic agent through said port.