[특허]Transdermal integrated actuator device, methods of making and using same

Transdermal integrated actuator device, methods of making and using same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61N-001/00
출원번호	US-0360698 (2009-01-27)
등록번호	US-8706210 (2014-04-22)
발명자 / 주소	Eppstein, Jonathan McRae, Stuart
출원인 / 주소	Nitto Denko Corporation
대리인 / 주소	King & Spalding LLP
인용정보	피인용 횟수 : 0 인용 특허 : 109

초록 ▼

The invention provides for a device for delivering a drug comprising: a. forming one or more micropores in a tissue membrane; andb. applying a patch containing a drug to the one or more micropores formed in the tissue membrane The invention also provides for methods of making and methods of using th

대표청구항 ▼

1. A device comprising: (a) a poration device comprising (i) an outer body defining a top of said poration device, said outer body containing a cavity;(ii) a controller board comprising driving electronics and a battery, said controller board being positioned within said cavity; and(iii) a tissue interface layer for contacting a tissue membrane of an animal, said tissue interface layer containing at least one probe element, each at least one probe element comprising a heated resistive element configured to conductively deliver thermal energy to cause ablation of said tissue membrane to a desired depth for formation of at least one micropore in said tissue membrane;(b) a patch comprising a drug, said patch applied to a microporated area of said tissue membrane after poration; and(c) an extension tab comprising a perforated tear line and releasably connected to a periphery of said tissue interface layer and a periphery of said patch. 2. The integrated poration and patch device according to claim 1, wherein the patch is a permeable solid structure. 3. The integrated poration and patch device according to claim 2, wherein the permeable solid structure is a porous polymer. 4. The integrated poration and patch device according to claim 1, wherein said tissue interface layer comprises a material selected from the group of a woven material, a film, a supporting layer, and a sheet. 5. The integrated poration and patch device according to claim 1, wherein said at least one probe element comprises a plurality of probe elements. 6. The integrated poration and patch device according to claim 4, wherein the plurality of probe elements form an array. 7. The integrated poration and patch device according to claim 1, wherein said tissue interface layer is removably attached to said outer body. 8. The integrated poration device and patch according to claim 1, further comprising a control button for initiating poration of said tissue membrane. 9. The integrated poration device system according to claim 1, wherein said tissue interface layer further comprises an adhesive layer for attachment of said poration device to said tissue membrane. 10. A system for selective formation of a plurality of micropores within a tissue membrane, comprising: (a) an outer body defining a cavity;(b) a controller board comprising driving electronics, said controller board being positioned within said cavity;(c) a thin film configured for contacting the tissue membrane, the thin film comprising a plurality of probe elements configured for selective formation of the plurality of micropores, each probe element of the plurality of probe elements comprising a heated resistive element configured to conductively deliver thermal energy to cause ablation of the tissue membrane to a desired depth for formation of at least one micropore in the tissue membrane, said thin film being in select electrical communication with the controller board;(d) a patch comprising a drug, said patch applied to the plurality of micropores in the tissue membrane after poration; and(e) an extension tab comprising a perforated tear line and releasably connected to a periphery of said thin film and a periphery of said patch. 11. The poration and patch system according to claim 10, wherein the patch is a permeable solid structure. 12. The poration and patch system according to claim 11, wherein the permeable solid structure is a porous polymer. 13. The poration and patch system according to claim 10, wherein the plurality of probe elements form an array. 14. The poration and patch system according to claim 10, wherein the thin film is removably attached to said outer body. 15. The poration and patch system according to claim 10, further comprising a control button for initiating poration of the tissue membrane. 16. The poration and patch system according to claim 10, further comprising: a tissue interface layer; andan adhesive layer for selectively releasable attachment of the tissue interface layer to the tissue membrane, wherein the thin film is positioned within the tissue interface layer.

이 특허에 인용된 특허 (109)

Yamada Yoshihisa (Kyoto JPX) Matsuoka Yuzo (Toyonaka JPX), 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2′5′-triones useful for the treatment and prophylaxis o.
상세보기
Subramanian Kumar (Alameda CA) Sugarman Jeffrey (Sunnyvale CA) Sterling Bernhard B. (Danville CA) Voss Fred (Pleasanton CA) Saltman Marina (Redwood City CA), Analytical cartridge and system for detecting analytes in liquid samples.
상세보기
Busta Heinz H. (Park Ridge IL) Bittner Michael L. (Naperville IL) Cuellar Richard E. (Glen Ellyn IL), Apparatus and method for electroporation.
상세보기
Eppstein Jonathan A. ; Hatch Michael R., Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications.
상세보기
Stanley Theodore H. (Salt Lake City UT) Ebert Charles D. (Salt Lake City UT) Higuchi William I. (Salt Lake City UT) Zhang Jie (Salt Lake City UT), Apparatus and method for noninvasive blood glucose monitoring.
상세보기
Eppstein, Jonathan A.; Hatch, Michael R.; Papp, Joseph, Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor.
상세보기
Hofmann Gunter A. (San Diego CA), Applicator for the electroporation of drugs and genes into surface cells.
상세보기
Tankovich Nikola I. (8925 Helen James Ave. San Diego CA 92126), Blood sampling device and method using a laser.
상세보기
Felgner Philip L. (Rancho Santa Fe CA) Kumar Raj (San Diego CA) Basava Channa (San Diego CA) Border Richard C. (Poway CA) Hwang-Felgner Jiin-Yu (Rancho Santa Fe CA), Cationic lipids for intracellular delivery of biologically active molecules.
상세보기
Abela George S. (80 Longfellow Rd. Wellesley MA 02181), Cell treatment apparatus and method.
상세보기
Johnson Mark E. ; Mitragotri Samir S. ; Blankschtein Daniel ; Langer Robert S. ; Pishko Michael ; Kost Joseph,ILX, Chemical and physical enhancers and ultrasound for transdermal drug delivery.
상세보기
Barnes Clarence W. (San Francisco CA), Control of laser photocoagulation using Raman radiation.
상세보기
Weaver James C. (Sudbury MA) Powell Kevin T. (Boston MA) Langer ; Jr. Robert S. (Newton MA), Control of transport of molecules across tissue using electroporation.
상세보기
Eppstein, Jonathan A.; Hatch, Michael R.; Papp, Joseph; Faupel, Mark L.; Kumar, Krishna, Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport.
상세보기
Jonathan A. Eppstein ; Michael R. Hatch ; Joseph Papp ; Mark L. Faupel ; Krishna Kumar, Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport.
상세보기
Jacques Steven L. (Somerville MA) McAuliffe Daniel J. (Revere MA) Blank Irvin H. (Belmont MA) Parrish John A. (Weston MA), Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport.
상세보기
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
상세보기
Zewert Thomas E. ; Pliquett Uwe ; Langer Robert S. ; Weaver James C., Delivery of nucleotides into organisms by electroporation.
상세보기
Cormier Michel J. N. ; Nat Avtar S. ; Neukermans Armand P. ; Block Barry, Device for enhancing transdermal agent delivery or sampling.
상세보기
Trautman Joseph Creagan ; Cormier Michel J. N. ; Kim Hyunok Lynn ; Zuck Michael G., Device for enhancing transdermal agent flux.
상세보기
Zuck Michael G., Device for enhancing transdermal agent flux.
상세보기
Tachibana Katsuro (6-18 ; Kusagae 1-chome Chuo-ku ; Fukuoka-shi ; Fukuoka 810 JPX) Tachibana Shunro (6-18 ; Kusagae 1-chome Chuo-ku ; Fukuoka-shi ; Fukuoka 810 JPX), Drug administration and humor sampling unit and an apparatus therefor.
상세보기
Shimada Jin (Falcon Heights MN) Shapland James E. (Shoreview ; both MN), Drug delivery by multiple frequency phonophoresis.
상세보기
Gerstel Martin S. (Palo Alto CA) Place Virgil A. (Palo Alto CA), Drug delivery device.
상세보기
Flanagan Dennis F. (1671 W. Main St. Willimantic CT 06226), Endermic method and apparatus.
상세보기
Long Gary (Cincinnati OH), Energy delivering cap element for end of optic fiber conveying laser energy.
상세보기
Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT), Enhancement of transdermal delivery with ultrasound and chemical enhancers.
상세보기
Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT) Kost Joseph (Omer MA ILX) Langer Robert S. (Newton MA), Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers.
상세보기
Kriesel Marshall (Saint Paul MN), Fluid delivery apparatus.
상세보기
Eriksson Elof (5 Lanark Rd. Welesley MA 02181), Gene delivery by microneedle injection.
상세보기
Tankovich Nicolai I. (8925 Helen James Ave. San Diego CA 92126), Hair removal device and method.
상세보기
Tankovich Nikolai I. (3957 Nobel Dr. Apt. 244 San Diego CA 92122), Hair removal device and method.
상세보기
Tankovich Nikolai I., Hair removal method.
상세보기
Tankovich Nikolai I. ; Zhao Zhong-Quan ; Fairchild Paul, Hair removal method.
상세보기
Nguyen Chanh (Newbury Park CA) Liu Takyiu (Newbury Park CA) Matloubian Mehran (Encino CA), High-Speed, low-noise millimeterwave hemt and pseudomorphic hemt.
상세보기
Hofmann Gunter A. (San Diego CA), Injection and electroporation apparatus for drug and gene delivery.
상세보기
Eppstein, Jonathan A.; Samuels, Mark A.; Hatch, Michael R., Integrated poration, harvesting and analysis device, and method therefor.
상세보기
Yum Su I. ; Roe Jeffrey N. ; Douglas Joel S., Interstitial fluid methods and devices for determination of an analyte in the body.
상세보기
Marchitto Kevin S. ; Flock Stephen T., Interstitial fluid monitoring.
상세보기
Abela George S. (Gainesville FL), Laser apparatus for the recanalization of vessels and the treatment of other cardiac conditions.
상세보기
Tankovich Nikolai, Laser assisted drug delivery.
상세보기
Abela George S. (Gainesville FL), Laser method and apparatus for the recanalization of vessels and the treatment of other cardiac conditions.
상세보기
Costello David J. (Albuquerque NM) Dergatchev Aleksei Y. (Hoover AL) Parkhurst Warren E. (Houston TX) Polushkin Valeri G. (Troitsk SUX) Kokhanovsky Sergey A. (Troitsk SUX), Laser skin perforator.
상세보기
Driller Jack (Ridgewood NJ) Faulkenberry William J. (Long Island City NY) Lizzi Frederic L. (Tenafly NJ), Local application of medication with ultrasound.
상세보기
Rosler, Richard S.; Engle, George M., Metal-silicide deposition using plasma-enhanced chemical vapor deposition.
상세보기
Godshall Ned Allen ; Anderson R. Rox, Method and apparatus for disruption of the epidermis.
상세보기
Grinwald Paul M. (434 Balwyn Road North Balwyn AUX 3104), Method and apparatus for enhanced drug permeation of skin.
상세보기
Eppstein Jonathan A., Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue.
상세보기
Eppstein, Jonathan A., Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue.
상세보기
Hayes Donald J. (Plano TX) Matthews J. Lester (Dallas TX) Judy Millard M. (Dallas TX), Method and apparatus for improved laser surgery.
상세보기
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Lowery Michael G. ; Graham Hugh W., Method and apparatus for obtaining blood for diagnostic tests.
상세보기
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Lowery Michael G. ; Schapira Thomas G., Method and apparatus for obtaining blood for diagnostic tests.
상세보기
Shain Eric B. ; Lowery Michael G. ; Cunningham David D. ; Henning Timothy P. ; Young Douglas F., Method and apparatus for obtaining blood for diagnostic tests.
상세보기
Saito Soichi,JPX ; Kajiwara Yuji,JPX ; Saito Atsushi,JPX, Method and apparatus of sampling suction effusion fluid.
상세보기
Svedman P.ang.l,CHX, Method and device for sensing bioelectrical signals.
상세보기
McQuade, Francis T.; Barto, Charles L., Method for chemically etching photo-defined micro electrical contacts.
상세보기
Shroot Braham (Antibes FRX) Green Philip (Nyon CHX), Method for delivering an active substance topically or percutaneously.
상세보기
Sibalis Dan (Stony Brook NY), Method for enhancing transdermal drug delivery of electrical drug applicators.
상세보기
Pliquett Uwe (Leipzig DEX) Prausnitz Mark R. (Dorchester MA) Weaver James C. (Sudburry MA) Langer Robert S. (Newton MA), Method for rapid temporal control of molecular transport across tissue.
상세보기
Hunt Andrew T. ; Cochran Joe K. ; Carter William Brent, Method for the combustion chemical vapor deposition of films and coatings.
상세보기
Guy Richard (San Francisco CA) Rao Girish (San Francisco CA), Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic su.
상세보기
Ito Narushi (Tokyo JPX), Method of eliminating stratum corneum from the skin and an instrument to be used therefor.
상세보기
Faiz Feisal Sherman ; Vadim Vladimirovich Yuzhakov ; Vladimir Gartstein ; Grover David Owens, Method of manufacturing an intracutaneous microneedle array.
상세보기
Douglas, Joel; Hugo, Jr., Robert, Micro infusion drug delivery device.
상세보기
Santini, Jr.,John T.; Cima,Michael J.; Langer,Robert S., Microchip drug delivery devices.
상세보기
Mark G. Allen ; Mark R. Prausnitz ; Devin V. McAllister ; Florent Paul Marcel Cros, Microneedle devices and methods of manufacture and use thereof.
상세보기
Eppstein Jonathan A. ; Hatch Michael R. ; Yang Difei, Microporation of human skin for drug delivery and monitoring applications.
상세보기
Eppstein Jonathan A. ; Hatch Michael R. ; Yang Difei, Microporation of human skin for monitoring the concentration of an analyte.
상세보기
Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
상세보기
Eppstein, Jonathan A., Microporation of tissue for delivery of bioactive agents.
상세보기
Smart Wilson H. ; Subramanian Kumar, Microsampling device and method of construction.
상세보기
Sherman,Faiz Feisal; Gartstein,Vladimir, Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation.
상세보기
Gartstein,Vladimir; Sherman,Faiz Feisal, Microstructures for delivering a composition cutaneously to skin.
상세보기
Rossi Carole,FRX ; Millot Philippe,FRX ; Esteve Daniel,FRX ; Mikler Claude,FRX ; Teillaud Eric,FRX, Miniature valve for filling the reservoir of an apparatus for the transdermal administration of medicine.
상세보기
Sibalis Dan (Stony Brook NY) Rosen Sanford (New York NY), Mounting system for transdermal drug applicator.
상세보기
Peery John R. (Palo Alto CA) Eckenhoff James B. (Los Altos CA), Multiple fluid pulse dispenser.
상세보기
Eppstein Jonathan A., Multiple mechanical microporation of skin or mucosa.
상세보기
Mitchen Joel R. (7418 - 41st Ave. Kenosha WI 53142), Non-invasive collection means and method.
상세보기
Bettinger David S. (8030 Coventry Grosse Ile MI 48138), On-demand iontophoretic system.
상세보기
Cooper, Eugene R., Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone.
상세보기
Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
상세보기
Cleary Gary W. (San Mateo CA) Roy Samir (Redwood City CA), Resilient transdermal drug delivery device.
상세보기
Eckenhoff James B. (Los Altos CA), Self-driven hypodermic injector.
상세보기
Jang Kwang K. (Kyungki-Do KRX), Skin perforating device for transdermal medication.
상세보기
Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions.
상세보기
Tankovich Nikolai I. (San Diego CA) Tang Kenneth Y. (Alpine CA) Hunter Allen M. (San Diego CA), Skin surface peeling process using laser.
상세보기
Tankovich Nikolai I. ; Sverdrup ; Jr. Lawrence H. ; Episcopo Richard G., Skin treatment process using laser.
상세보기
Roser Bruce J.,GBX ; Kampinga Jaap,NLX ; Colaco Camilo,GBX ; Blair Julian,GBX, Solid dose delivery vehicle and methods of making same.
상세보기
Frazier,A. Bruno; Brazzle,John D., Surface micromachined microneedles.
상세보기
Say James L. ; Long Nathan R. ; Peper Eric A. ; Sakslund Henning, System and method for measuring a bioanalyte such as lactate.
상세보기
Kamen Dean L., System for delivery of drugs by transport.
상세보기
Currie, John F.; Paranjape, Makarand; Peck, Carl C.; White, Robert; Schneider, Thomas W., Systems and methods for monitoring health and delivering drugs transdermally.
상세보기
Faupel,Mark L.; Kumar,Krishna; Farquhar,J. David; Vreeke,Mark; Smith,Alan; Hatch,Michael; Woods,Teresa, Tissue interface device.
상세보기
Gross Joseph (Moshav Mazor ILX), Transcutaneous drug delivery applicator.
상세보기
Lee Hai Bang (Taejeon KRX) Shin Bung Chul (Taejeon KRX), Transdermal administration method of protein or peptide drug and its administration device thereof.
상세보기
Sibalis Dan (Stony Brook NY), Transdermal drug applicator and electrodes therefor.
상세보기
Sanders Harold F. (Palo Alto CA) Cheng Yu-Ling (Cupertino CA) Enscore David J. (Saratoga CA) Libicki Shari B. (Palo Alto CA), Transdermal drug composition with dual permeation enhancers.
상세보기
Avrahami Zohar,ILX, Transdermal drug delivery and analyte extraction.
상세보기
Eppstein,Jonathan; McRae,Stuart; Papp,Joseph, Transdermal drug delivery device, method of making same and method of using same.
상세보기
Eppstein,Jonathan; McRae,Stuart; Smith,Alan, Transdermal drug delivery patch system, method of making same and method of using same.
상세보기
Sibalis Dan (Stony Brook NY), Transdermal drug patch with microtubes.
상세보기
Gross Joseph (Moshav Mazor ILX) Zucker Shlomo (Mihmoret ILX), Transdermal or interdermal drug delivery devices.
상세보기
Svedman Pal,SEX, Transdermal perfusion of fluids.
상세보기
Hofmann Gunter A. (San Diego CA), Transsurface drug delivery by electrofusion of microbubbles to the tissue surface.
상세보기
Lipkovker Lev M. (Bellevue WA), Ultrasonic transdermal drug delivery system.
상세보기
Kost Joseph (Omer ILX) Levy Drora (Herzlia MA ILX) Langer Robert S. (Somerville MA), Ultrasound enhancement of transdermal drug delivery.
상세보기
Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
상세보기
Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
상세보기
Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Transdermal integrated actuator device, methods of making and using same 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허에 인용된 특허 (109)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Transdermal integrated actuator device, methods of making and using same 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허에 인용된 특허 (109)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트