IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0853082
(2010-08-09)
|
등록번호 |
US-8708966
(2014-04-29)
|
발명자
/ 주소 |
- Allen, Mark G.
- Prausnitz, Mark R.
- McAllister, Devin V.
- Cros, Florent Paul Marcel
|
출원인 / 주소 |
- Georgia Tech Research Corporation
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
4 인용 특허 :
92 |
초록
▼
Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous
Microneedle devices are provided for transport of molecules across tissue barriers and for use as microflameholders. In a preferred embodiment for transport across tissue, the microneedles are formed of a biodegradable polymer. Methods of making these devices, which can include hollow and/or porous microneedles, are also provided. A preferred method for making a microneedle includes forming a micromold having sidewalls which define the outer surface of the microneedle, electroplating the sidewalls to form the hollow microneedle, and then removing the micromold from the microneedle. In a preferred method of use, the microneedle device is used to deliver material into or across a biological barrier from chambers in connection with at least one of the microneedles. The device preferably further includes a means for controlling the flow of material through the microneedles. Representative examples of these means include the use of permeable membranes, fracturable impermeable membranes, valves, and pumps.
대표청구항
▼
1. A method for delivering of active agent across a biological barrier, the method comprising the steps of: puncturing the biological barrier with a plurality of microneedles, the microneedles attached to or integrally formed with a substrate, wherein each of the microneedles is formed of a biodegra
1. A method for delivering of active agent across a biological barrier, the method comprising the steps of: puncturing the biological barrier with a plurality of microneedles, the microneedles attached to or integrally formed with a substrate, wherein each of the microneedles is formed of a biodegradable polymer and an active agent dispersed in the biodegradable polymer of the microneedles;delivering the active agent solely through biodegradation of the biodegradable polymer of the microneedles in the biological barrier. 2. The method of claim 1, wherein the biodegradable polymer comprises a plurality of biodegradable polymers. 3. The method of claim 2, wherein the biodegradable polymer comprises at least one of polylactides, polyglycolides, polylactide-co-glycolide, copolymers of polyethylene glycol, polyanhydrides, poly(ortho)esters, polyurethanes, poly(butric acid), poly(valeric acid), and poly(lactide-co-caprolactone). 4. The method of claim 1, wherein the biodegradable polymer comprises a biodegradable polymer and a non-biodegradable polymer. 5. The method of claim 1, wherein the biodegradation occurs by way of chemical breakdown of the biodegradable polymer. 6. The method of claim 1, wherein the biodegradation occurs by way of biodissolution of the biodegradable polymer. 7. The method of claim 1, wherein the microneedles are between 1 μm and 1 mm long, inclusive. 8. The method of claim 1, wherein the microneedles are between 10 μm and 500 μm long, inclusive. 9. The method of claim 1, wherein the microneedles are between 30 μm and 200 μm long, inclusive. 10. The method of claim 1, wherein the microneedles have a cross-sectional dimension between 10 nm and 1 mm, inclusive. 11. The method of claim 1, wherein the microneedles have a cross-sectional dimension between 1 μm and 200 μm, inclusive. 12. The method of claim 1, wherein the microneedles have a cross-sectional dimension between 10 μm and 100 μm, inclusive. 13. The method of claim 1, wherein the microneedles have a circular cross section with an outer diameter between 10 μm and 100 μm, inclusive. 14. The method of claim 1, wherein the substrate comprises a flexible material. 15. The method of claim 1, wherein the active agent is dispersed throughout the biodegradable polymer. 16. The method of claim 1, wherein the active agent is a drug. 17. The method of claim 16, wherein the drug comprises at least one of a protein, an enzyme, a polysaccharide, a polynucleotide, an organic compound, and an inorganic compound. 18. The method of claim 1, wherein at least one of the microneedles comprises a break site to remove the at least one of the microneedles from the substrate. 19. The method of claim 18, wherein the break site comprises a notch in the at least one of the microneedles. 20. The method of claim 18, wherein the break site is located adjacent the tip of the microneedles.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.