초록

A pharmaceutical delivery device, such as a suppository or pessary, comprises a synthetic prostaglandin PGE1 analogue (e.g. misoprostol) in a solid polyurethane hydrogel.

대표청구항 ▼

1. A pharmaceutical delivery device, comprising: a formulation comprising misoprostol in a polyurethane hydrogel, wherein the hydrogel has a water content of less than 0.2% by weight. 2. The delivery device of claim 1, wherein the polyurethane hydrogel is a cross-linked hydrogel. 3. The delivery dev

1. A pharmaceutical delivery device, comprising: a formulation comprising misoprostol in a polyurethane hydrogel, wherein the hydrogel has a water content of less than 0.2% by weight. 2. The delivery device of claim 1, wherein the polyurethane hydrogel is a cross-linked hydrogel. 3. The delivery device of claim 2, wherein the cross-linked hydrogel is the reaction product of a polyethylene glycol, a triol and a diisocyanate. 4. The delivery device of claim 3, wherein the polyethylene glycol has a molecular weight ranging between 4000 and 35,000. 5. The delivery device of claim 4, wherein the polyethylene glycol has a molecular weight ranging between 4000 and 8000. 6. The delivery device of claim 3, wherein the polyethylene glycol is selected from the group consisting of PEG2000, PEG4000, PEG6000 and PEG8000. 7. The delivery device of claim 3, wherein the triol is hexanetriol. 8. The delivery device of claim 3, wherein the diisocyanate is selected from the group consisting of dicyclohexylmethane diisocyanate, dicyclohexylmethane-4,4-diisocyanate, diphenylmethane-4,4-diisocyanate, and 1,6-hexamethylene diisocyanate. 9. The delivery device of claim 1, wherein the polyurethane hydrogel is a linear hydrogel. 10. The delivery device of claim 1, wherein the misoprostol is present in the formulation in an amount ranging between 25 and 400 μg. 11. The delivery device of claim 10, wherein the misoprostol is present in the formulation in an amount of 100 μg. 12. The delivery device of claim 10, wherein the misoprostol is present in the formulation in an amount of 200 μg. 13. The delivery device of claim 1, wherein the hydrogel has a water content of less than 0.1% by weight. 14. The delivery device of claim 1, wherein the hydrogel has a water content in the range of 0.1% to 0.2% by weight. 15. The delivery device of claim 1, further comprising butylated hydroxyl anisole. 16. The delivery device of claim 1, wherein the device is selected from the group consisting of a suppository, a vaginal pessary, a buccal insert and an implant. 17. A method for inducing labor, comprising: contacting the delivery device of claim 1 with a body cavity. 18. The method of claim 17, wherein the delivery device is a vaginal pessary. 19. An article, comprising: the pharmaceutical delivery device of claim 1, anda desiccant. 20. The delivery device of claim 1, wherein the misoprostol is present in the formulation in an amount ranging between 100 and 400 μg. 21. The delivery device of claim 1, wherein the misoprostol is present in the formulation in an amount ranging between 100 and 200 μg.