(−)-epigallocatechin gallate derivatives for inhibiting proteasome
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07D-311/00
A61K-031/25
출원번호
US-0416657
(2012-03-09)
등록번호
US-8710248
(2014-04-29)
발명자
/ 주소
Chan, Tak-Hang
Lam, Wai-Har
Chow, Larry Ming-Cheung
Dou, Qing Ping
Kuhn, Deborah Joyce
Kazi, Aslamuzzaman
Wan, Sheng Biao
Landis-Piwowar, Kristin R.
출원인 / 주소
The Hong Kong Polytechnic University
대리인 / 주소
Buchanan Ingersoll & Rooney PC
인용정보
피인용 횟수 :
1인용 특허 :
2
초록
A method of reducing tumor cell growth, the method including administering an effective amount of a compound having the formula:
대표청구항▼
1. A method of reducing tumor cell growth, the method comprising administering an effective amount of a compound having the formula: wherein R11 is —H;R5 is —H; andwherein the formula satisfies one of the following conditions (1) to (4):(1) each of R2 and R4 is —H, and each of R12, R13, R21, R22, an
1. A method of reducing tumor cell growth, the method comprising administering an effective amount of a compound having the formula: wherein R11 is —H;R5 is —H; andwherein the formula satisfies one of the following conditions (1) to (4):(1) each of R2 and R4 is —H, and each of R12, R13, R21, R22, and R3 is a benzoate group;(2) each of R13, R2, and R4 is —H, and each of R12, R21, R22, and R3 is an acetate group;(3) each of R13, R2, and R4 is —H, and each of R12, R21, R22, and R3 is a benzoate group;(4) R13 is —H, and each of R12, R21, R22, R2 and R3, and R4 is an acetate group. 2. A method of manufacturing a medicament for reducing tumor cell growth, the method comprising forming a medicament comprising a compound having the formula: wherein R5 is —H; andwherein the formula satisfies one of the following conditions (1) to (3):(1) each of R11, R12, R13, R21, R22, R2, R3, and R4 is an acetate group;(2) each of R11, R12, R13, R21, R22 is an acetate group, R2 is an acetate group, and each of R3 and R4 is —H;(3) each of R11, R12, R13, R21, R22 is an acetate group, each of R2 and R4 is an acetate group, and R3 is —H. 3. A method of manufacturing a medicament for reducing tumor cell growth, the method comprising forming a medicament comprising a compound having the formula: wherein the formula satisfies one of conditions (1) and (2): (1) R1 is —H, R2 is —OH, and each of R3 and R4 is —H;(2) R1 is —H, each of R2 and R4 is —OH, and R3 is —H. 4. The method of claim 1, wherein each of R2 and R4 is —H, and each of R12, R13, R21, R22, and R3 is a benzoate group. 5. The method of claim 1, wherein each of R13, R2, and R4 is —H, and each of R12, R21, R22, and R3 is an acetate group. 6. The method of claim 1, wherein each of R13, R2, and R4 is —H, and each of R12, R21, R22, and R3 is a benzoate group. 7. The method of claim 1, wherein R13 is —H, and each of R12, R21, R22, R2, R3, and R4 is an acetate group. 8. The method of claim 2, wherein each of R11, R12, R13, R21, R22, R2, R3, and R4 is an acetate group. 9. The method of claim 2, wherein each of R11, R12, R13, R21, and R22 is an acetate group, R2 is an acetate group, and each of R3 and R4 is —H. 10. The method of claim 2, wherein each of R11, R12, R13, R21, and R22 is an acetate group, each of R2 and R4 is an acetate group, and R3 is —H. 11. The method of claim 3, wherein the formula satisfies condition (1). 12. The method of claim 3, wherein the formula satisfies condition (2). 13. The method of claim 1, wherein the compound is effective to inhibit proteasome. 14. The method of claim 2, wherein the compound is effective to inhibit proteasome. 15. The method of claim 3, wherein the compound is effective to inhibit proteasome. 16. The method of claim 1, wherein the compound is administered to tumor cells.
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이 특허에 인용된 특허 (2)
Chan, Tak Hang; Lam, Wai Har; Chow, Larry Ming Cheung; Dou, Qing Ping; Kuhn, Deborah Joyce; Kazi, Aslamuzzaman, (-)-Epigallocatechin gallate derivatives for inhibiting proteasome.
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