Compositions and methods for promoting bone formation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/28
A61K-038/16
A61K-038/17
A61K-038/18
A61K-038/19
A61K-038/20
A61K-038/22
출원번호
US-0605746
(2009-10-26)
등록번호
US-8722075
(2014-05-13)
발명자
/ 주소
Shimp, Lawrence A.
Behnam, Keyvan
Wei, Guobao
Selim, Abdulhafez A.
출원인 / 주소
Warsaw Orthopedic, Inc.
대리인 / 주소
Sorell Lenna & Schmidt LLP
인용정보
피인용 횟수 :
9인용 특허 :
164
초록
A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
대표청구항▼
1. A load-bearing implant for promoting bone formation comprising: an implantable material comprising a demineralized bone matrix, fully mineralized bone, calcium and mesenchymal stem cells, wherein the mesenchymal stems cells are seeded within the implant; anda stimulating substance, wherein the st
1. A load-bearing implant for promoting bone formation comprising: an implantable material comprising a demineralized bone matrix, fully mineralized bone, calcium and mesenchymal stem cells, wherein the mesenchymal stems cells are seeded within the implant; anda stimulating substance, wherein the stimulating substance stimulates osteoclast formation and the stimulating substance comprises osteoclast precursor cells that stimulate osteoclast formation, and the implant includes the mesenchymal stem cells and the osteoclast precursor cells in a ratio of 1:4. 2. The implant of claim 1, wherein the material further comprises hydroxyapatite. 3. The implant of claim 1, wherein the material further comprises a calcium phosphate material. 4. The implant of claim 1, further comprising a second stimulating substance, wherein the second stimulating substance stimulates osteoblast formation or recruitment in vivo. 5. The implant of claim 1, further comprising a second stimulating substance, wherein the second stimulating substance enhances resorbing activity of osteoclasts in vivo. 6. The implant of claim 1, wherein the stimulating substance further comprises one of RANKL, MCSF, ADAM-12, PTH, PTHrP, VEGF, hydrocortisone, 1,25 dihydroxyvitamin D3, PGE2, TNFalpha, IL-1beta, IL-3, IL-6, IL-11, and bFGF. 7. The implant of claim 1, wherein the stimulating substance further comprises a DNA that encodes one or more of RANKL, MCSF, ADAM-12, PTH, PTHrP, VEGF, TNFalpha, IL-1beta, IL-3, IL-6, IL-11, and bFGF. 8. The implant of claim 1, wherein the implantable material comprises large segmental allograft pieces. 9. The implant of claim 1, wherein the mesenchymal stems cells comprise mesenchymal cell line C2C12.
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이 특허에 인용된 특허 (164)
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