IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0769625
(2013-02-18)
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등록번호 |
US-8722733
(2014-05-13)
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발명자
/ 주소 |
- Karaborni, Sami
- Leung, Manshiu
- Mao, Chen
- Thalladi, Venkat R.
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출원인 / 주소 |
|
대리인 / 주소 |
Kilpatrick Townsend & Stockton LLP
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인용정보 |
피인용 횟수 :
0 인용 특허 :
49 |
초록
Crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, methods of making the hydrate, pharmaceutical compositions containing the hydrate, and methods of using the hydrate to treat diseases or disorders such as Parkinson's disease are provided.
대표청구항
▼
1. A method of treating a disease in a patient comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, which exhibits characteristic s
1. A method of treating a disease in a patient comprising administering to a patient in need of such treatment a therapeutically effective amount of a compound crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, which exhibits characteristic scattering angles (2θ) at least at 6.0°±0.2°, 9.1°±0.2°, 14.6°±0.2°, 16.1°±0.2°, 16.6°±0.2°, and 18.5°±0.2° in an X-ray powder diffraction pattern measured using Cu—Kα radiation, wherein the disease is chosen from Parkinson's disease, depression, attention deficit disorder, schizophrenia, manic depression, cognitive impairment disorders, restless legs syndrome, periodic limb movement disorders, tardive dyskinesia, Huntington's disease, Tourette's syndrome, hypertension, addictive disorders, congestive heart failure, and excessive daytime sleepiness. 2. The method of claim 1, wherein the compound exhibits characteristic scattering angles (2θ) at least at 6.0°±0.2°, 9.1°±0.2°, 9.6°±0.2°, 12.0°±0.2°, 13.8°±0.2°, 14.6°±0.2°, 15.1°±0.2°, 15.6°±0.2°, 16.1°±0.2°, 16.6°±0.2°, 17.6°±0.2°, 18.5°±0.2°, and 19.2°±0.2° in an X-ray powder diffraction pattern measured using Cu—Kα radiation. 3. The method of claim 1, wherein the compound exhibits characteristic scattering angles (2θ) at least at 6.0°±0.2°, 9.1°±0.2°, 9.6°±0.2°, 12.0°±0.2°, 13.8°±0.2°, 14.6°±0.2°, 15.1°±0.2°, 15.6°±0.2°, 16.1°±0.2°, 16.6°±0.2°, 17.6°±0.2°, 18.5°±0.2°, 19.2°±0.2°, 20.8°±0.2°, 21.9°±0.2°, 22.8°±0.2°, 23.4°±0.2°, 23.7°±0.2°, 23.9°±0.2°, and 26.5°±0.2° in an X-ray powder diffraction pattern measured using Cu—Kα radiation. 4. The method of claim 1, wherein the compound exhibits characteristic scattering angles (2θ) at least at 6.0°±0.2°, 9.1°±0.2°, 9.6°±0.2°, 11.2°±0.2°, 12.0°±0.2°, 12.8°±0.2°, 13.8°±0.2°, 14.3°±0.2°, 14.6°±0.2°, 15.1°±0.2°, 15.6°±0.2°, 16.1°±0.2°, 16.6°±0.2°, 17.6°±0.2°, 18.5°±0.2°, 18.7°±0.2°, 19.2°±0.2°, 20.5°±0.2°, 20.8°±0.2°, 21.1°±0.2°, 21.9°±0.2°, 22.8°±0.2°, 23.4°±0.2°, 23.7°±0.2°, 23.9°±0.2°, 24.7°±0.2°, 26.5°±0.2°, 28.2°±0.2°, 28.3°±0.2°, and 29.5°±0.2° in an X-ray powder diffraction pattern measured using Cu—Kα radiation. 5. The method of claim 1, wherein the compound comprises from about 1.4 moles water to about 1.6 moles water to mole of the compound. 6. The method of claim 1, wherein the compound comprises from about 5.3 wt-% to about 5.7 wt-% water. 7. The method of claim 1, wherein the compound is prepared by a process comprising processing (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate by high shear wet granulation using a water content ranging from about 10 wt-% to about 20 wt-% to provide granules comprising the crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate. 8. The method of claim 1, wherein the compound is prepared by a process comprising: dissolving (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate in a solvent comprising water to form a solution, wherein the water activity in the solvent is greater than about 0.6; and crystallizing the (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate to provide the crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate. 9. The method of claim 1, wherein the solvent comprises isopropanol and at least about 7%-bv water. 10. The method of claim 1, wherein the disease is Parkinson's disease. 11. The method of claim 1, wherein the therapeutically effective amount of (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate is from about 200 mg to about 7 g per day. 12. A method of treating a disease in a patient comprising administering to a patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of a compound crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, which exhibits characteristic scattering angles (2θ) at least at 6.0°±0.2°, 9.1°±0.2°, 14.6°±0.2°, 16.1°±0.2°, 16.6°±0.2°, and 18.5°±0.2° in an X-ray powder diffraction pattern measured using Cu—Kα radiation, wherein the disease is chosen from Parkinson's disease, depression, attention deficit disorder, schizophrenia, manic depression, cognitive impairment disorders, restless legs syndrome, periodic limb movement disorders, tardive dyskinesia, Huntington's disease, Tourette's syndrome, hypertension, addictive disorders, congestive heart failure, and excessive daytime sleepiness. 13. The method of claim 12, wherein the pharmaceutical composition comprises an L-aromatic amino acid decarboxylase inhibitor. 14. The method of claim 12, wherein the pharmaceutical composition comprises a catechol-O-methyltransferase inhibitor. 15. The method of claim 12, wherein the pharmaceutical composition is formulated for sustained release oral administration. 16. A method of treating a disease in a patient comprising administering to a patient in need of such treatment an oral dosage form comprising a therapeutically effective amount of a compound crystalline (2R)-2-phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate, hydrate, which exhibits characteristic scattering angles (2θ) at least at 6.0°±0.2°, 9.1°±0.2°, 14.6°±0.2°, 16.1°±0.2°, 16.6°±0.2°, and 18.5°±0.2° in an X-ray powder diffraction pattern measured using Cu—Kα radiation, wherein the disease is chosen from Parkinson's disease, depression, attention deficit disorder, schizophrenia, manic depression, cognitive impairment disorders, restless legs syndrome, periodic limb movement disorders, tardive dyskinesia, Huntington's disease, Tourette's syndrome, hypertension, addictive disorders, congestive heart failure, and excessive daytime sleepiness. 17. The method of claim 16, wherein the oral dosage form comprises an L-aromatic amino acid decarboxylase inhibitor. 18. The method of claim 16, wherein the oral dosage form comprises a catechol-O-methyltransferase inhibitor. 19. The method of claim 16, wherein the oral dosage form is a sustained release oral form.
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