N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07C-233/00
C07C-235/00
C07C-237/00
C07C-239/00
출원번호
US-0870368
(2007-10-10)
등록번호
US-8722929
(2014-05-13)
발명자
/ 주소
Vernier, Jean-Michel
Song, Jianlan
Chen, Huanming
Hong, Zhi
출원인 / 주소
Valeant Pharmaceuticals International
대리인 / 주소
Jones Day
인용정보
피인용 횟수 :
0인용 특허 :
55
초록
This invention provides compounds of formula A and formula B which are modulators of potassium ion channels and are useful for the treatment of seizure disorders.
대표청구항▼
1. A compound of formula A where Ar is phenyl U=—C(Rm)═; Ra and R′a are, independently, H, F, Cl, methyl, methoxy, fluoromethyl, difluoromethyl, or trifluoromethyl; Rm is H, F, Cl, methyl, fluoromethyl, difluoromethyl, trifluoromethyl or methoxy; R′m is F, Cl, fluoromethyl, difluoromethyl, trifluoro
1. A compound of formula A where Ar is phenyl U=—C(Rm)═; Ra and R′a are, independently, H, F, Cl, methyl, methoxy, fluoromethyl, difluoromethyl, or trifluoromethyl; Rm is H, F, Cl, methyl, fluoromethyl, difluoromethyl, trifluoromethyl or methoxy; R′m is F, Cl, fluoromethyl, difluoromethyl, trifluoromethyl or methoxy; RN is H orC1-C4 alkyl, which may be straight-chain, branched, or cyclic; and RO is H, isopropyl, sec-butyl, or straight-chain C1-C8 alkyl, alkenyl, or alkynyl, any of which may be substituted by methyl, fluoro, chloro methoxy, phenyl, or benzoyloxy, where the methyl, methoxy, phenyl, and benzyl groups are optionally substituted with one or two fluorine atoms or one or two chlorine atoms. 2. The compound of claim 1, where Ra is CF3, F, or Cl and R′a is H or F. 3. The compound of claim 2, where R′m is F and RN is H or methyl. 4. The compound of claim 3, where RO is C1-C4 alkyl, C1-C4 alkenyl, or CH3O—(CH2)nCH2—, where n is 0, 1, 2, or 3. 5. The compound of claim 1, where RO is selected from the group methyl, ethyl, propyl, butyl sec-butyl, pentyl, hexyl, 2-chloroethyl, 3-chloropropyl, 4-chlorobutyl, 2-fluoroethyl, 3-fluoropropyl, 4-fluorobutyl, 2,2,2-trifluoroethyl, 2,2,2-trichloroethyl, methoxyethyl, benzyloxyethyl, benzyl, o-chlorobenzyl, o-, o′-dichlorobenzyl o-fluorobenzyl, and o-, o′-difluorobenzyl. 6. A composition comprising a pharmaceutically acceptable carrier and one or more of the following: a compound of claim 1; a salt or ester thereof.
Tibes Ulrich (Frankfurt am Main DEX) Weischer Carl H. (Bonn DEX) Hettche Helmut (Offenbach am Main DEX) Breuel Hans-Peter (Mainz DEX) Gunesch Dietmar (Offenbach am Main DEX), Combination of flupirtin and anticholinergic acting spasmolytic.
Piyasena Hewawasam ; Pierre Dextraze CA; Valentin K. Gribkoff ; Gene G. Kinney ; Steven I. Dworetzky, Fluoro oxindole derivatives as modulators if KCNQ potassium channels.
Aberg A. K. Gunnar (Lawrenceville NJ) Ogletree Martin L. (Newtown PA) O\Keefe Eugene H. (Newtown PA), Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activato.
Lobisch Michael (Ober-Ramstadt DEX) Venhaus Ralph (Heppenheim DEX) Nickel Bernd (Mhltal DEX) Szelenyi Istvan (Schwaig DEX) Engel Jrgen (Alzenau DEX) Emig Peter (Niederdorfelden DEX), Pharmaceutical composition comprising flupirtine and its use to combat Parkinson disorders.
Lobisch Michael (Ober-Ramstadt DEX) Venhaus Ralph (Heppenheim DEX) Nickel Bernd (Mhltal DEX) Szelenyi Istvan (Schwaig DEX) Engel Jrgen (Alzenau DEX) Emig Peter (Niederdorfelden DEX), Pharmaceutical composition comprising flupirtine and its use to combat muscular tension.
Dieter Hans-Reinhold (Darmstadt DEX) Engel Jurgen (Alzenau DEX) Kutscher Bernhard (Maintal DEX) Polymeropoulos Emanuel (Frankfurt DEX) Szelenyi Stefan (Schwaig DEX) Nickel Bernd (Muhltal DEX), Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositi.
Carroll, William A.; Chen, Yiyuan; Holladay, Mark W.; Kort, Michael E.; Kym, Philip R.; Sullivan, James P.; Tang, Rui; Yi, Lin; Zhang, Henry Q.; Drizin, Irene, Potassium channel openers.
Tibes Ulrich (Am Sandberg 102 D-6000 Frankfurt am Main 70 DEX) Weischer Carl H. (Schmidtbonnstrasse 8 D-5300 Bonn 1 DEX) Hettche Helmut (Buchrainweg 65 D-6050 Offenbach am Main DEX) Breuel Hans-Peter, Synergistic combination of flupirtin and non-steroidal antiphlogistic.
Rostock Angelika,DEX ; Rundfeldt Chris,DEX ; Tober Christine,DEX ; Bartsch Reni,DEX, Use of 2-4-amino-4-(4-fluorobenzylamino) (-1-ethoxy-carbonylaminobenzene for the prophylaxis and treatment of the neurod.
Rostock Angelika,DEX ; Rundfeldt Chris,DEX ; Tober Christine,DEX ; Bartsch Reni,DEX, Use of 4-amino-4-(4-fluorobenzylamino)-1-ethoxy-carbonylaminobenzene for the prophylaxis and treatment of reduced cerebr.
Rundfeldt Chris,DEX ; Bartsch Reni,DEX ; Rostock Angelika,DEX ; Tober Christine,DEX ; Dost Rita,DEX, Use of retigabine for the treatment of neuropathic pain.
Rundfeldt,Chris; Kuss,Hildegard; Draheim,Regina; Bernoester,Katrin, Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome.
Demopulos Gregory A. ; Pierce Pamela A. ; Herz Jeffrey M., Vascular irrigation solution and method for inhibition of pain, inflammation, spasm and restenosis.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.