$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Compositions and methods for enhancing drug delivery across and into ocular tissues

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/03
  • A61K-038/16
출원번호 US-0608975 (2012-09-10)
등록번호 US-8729010 (2014-05-20)
발명자 / 주소
  • Rothbard, Jonathan B.
  • Wender, Paul A.
  • McGrane, Leo P.
  • Sista, Lalitha V. S.
  • Kirschberg, Thorsten A.
출원인 / 주소
  • KAI Pharmaceuticals, Inc.
대리인 / 주소
    McDermott Will & Emery LLP
인용정보 피인용 횟수 : 0  인용 특허 : 33

초록

This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier.

대표청구항

1. A method for enhancing delivery of a compound into and across an animal ocular tissue, the method comprising: administering to the ocular tissue a conjugate comprising the compound and a delivery-enhancing transporter, wherein:i. the compound is attached to the delivery-enhancing transporter thro

이 특허에 인용된 특허 (33)

  1. Nichols Alfred C. (Texas City TX) Yielding K. Lemone (Galveston TX), 4-hydroxyquinaldic acid derivatives.
  2. Shen Wei C. (145 Richdale Rd. Needham MA 02194) Ryser Hugues J. (503 Annursnac Hill Rd. Concord MA 01742), Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers.
  3. Twist Michael (Toronto CAX) Sumner-Smith Martin (Bolton CAX), Anti-viral compositions.
  4. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
  5. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
  6. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
  7. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into ocular tissues.
  8. Rothbard,Jonathan B.; Wender,Paul A.; McGrane,P. Leo; Sista,Lalitha V. S.; Kirschberg,Thorsten A., Compositions and methods for enhancing drug delivery across and into ocular tissues.
  9. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for treating inflammatory diseases of the skin.
  10. Shashoua Victor E. ; Swindell Charles S. ; Webb Nigel L. ; Bradley Matthews O., DHA-pharmaceutical agent conjugates of taxanes.
  11. Hanson Richard W. ; Perales Jose C. ; Ferkol ; Jr. Thomas W., Delivery of compacted nucleic acid to cells.
  12. Brewer Stephen J. (High Wycombe GB2) Sassenfeld Helmut M. (Benson GB2), Fused polypeptides and methods for their detection.
  13. Rowland George Ferdinand (Gerrards Cross EN), Immunological materials.
  14. Kozarich John W. (Cambridge MA) Musso Gary F. (Hopkinton MA) Malfroy-Camine Bernard (Arlington MA), Increasing blood-brain barrier permeability with permeabilizer peptides.
  15. Jonathan B. Rothbard ; Paul A. Wender, Method and composition for enhancing transport across biological membranes.
  16. Rothbard Jonathan B. ; Wender Paul A., Method and composition for enhancing transport across biological membranes.
  17. Katz Robert ; Tomoaia-Cotisel Maria, Method for delivering active agents to mammalian brains in a complex with eicosapentaenoic acid or docosahexaenoic acid-.
  18. Bretton Randolph H., Method for destroying residual lens epithelial cells.
  19. Bretton Randolph H. (Maryland Heights MO), Method for destroying residual lens epithelial cells.
  20. Skubitz Amy P. N. ; Furcht Leo T. ; Balles Mark ; Gregerson Dale S. ; Agarwal Anita ; Wright Martha M. ; Murali Shobana, Method for treating conditions of the eye using polypeptides.
  21. Ryser Hugues J. (Concord MA) Shen Wei-Chiang (Needham MA), Method of effecting cellular uptake of molecules.
  22. Ryser Hugues J. P. (Concord MA) Shen Wei-Chiang (Needham MA), Method of effecting cellular uptake of molecules.
  23. Sumner-Smith Martin (Bolton CAX) Barnett Richard W. (Mississauga CAX) Reid Lorne S. (Toronto CAX) Sonenberg Nahum (St. Luc CAX), Peptide-based inhibitors of HIV replication.
  24. Sumner-Smith Martin,CAX ; Barnett Richard W.,CAX ; Reid Lorne S.,CAX ; Sonenberg Nahum,CAX, Peptide-based inhibitors of HIV replication.
  25. Kabanov Alexander Victorovich ; Alakhov Valery Yulievich,CAX, Polymer linked biological agents.
  26. Mongelli Nicola (Milan ITX) Angelucci Francesco (Milan ITX) Pesenti Enrico (Cologno Monzese ITX) Suarato Antonino (Milan ITX) Biasoli Giovanni (Gavirate ITX), Polymer-bound paclitaxel derivatives.
  27. Brewer Stephen J. (High Wycombe GB2) Sassenfeld Helmut M. (Benson GB2), Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase.
  28. Beug Hartmut (Vienna ATX) Birnstiel Max L. (Vienna ATX) Cotten Matthew (Vienna ATX) Wagner Ernst (Langenzersdorf ATX), Protein-polycation conjugates.
  29. Dean Richard T. (Downingtown PA) Boutin Raymond H. (Wilmington DE) Lister-James John (Glenmoore PA), Proteins modified with positively charged carriers and compositions prepared therefrom.
  30. Frankel Alan ; Pabo Carl ; Barsoum James G. ; Fawell Stephen E. ; Pepinsky R. Blake, Tat-derived transport polypeptides and fusion proteins.
  31. Twist ; deceased Michael (late of Toronto CAX by Harvey L. Hamburg ; Administrator ) Sumner-Smith Martin (Bolton CAX), Treatment of cytomegalovirus infection.
  32. Twist Michael,CAX ; Barnett Richard W.,CAX ; Reid Lorne S.,CAX ; Sumner-Smith Martin,CAX, Treatment of herpesvirus infection.
  33. Li Chun ; Wallace Sidney ; Yu Dong-Fang ; Yang David J., Water soluble paclitaxel prodrugs.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트