로그인시 본인확인과정이 필요할 수 있습니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기
| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0748999 (2010-03-29) |
| 등록번호 | US-8742072 (2014-06-03) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 1 인용 특허 : 442 |
A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a unitary article that may be provided at the site of a skeletal defect. An osteoinductive component may be fu
A biocompatible synthetic bone growth composition comprising a fibrillar collagen component and a calcium phosphate component. The composition is formed into particles, and then formed into a unitary article that may be provided at the site of a skeletal defect. An osteoinductive component may be further added, either before or after forming the unitary article. The composition may be formulated as a paste or putty and facilitates bone growth and/or repair.
1. A biocompatible synthetic bone growth composition comprising a fibrillar collagen component, an acidic calcium phosphate component, and demineralized bone. 2. The composition of claim 1 wherein the fibrillar collagen component is obtained from a natural source. 3. The composition of claim 2 where
1. A biocompatible synthetic bone growth composition comprising a fibrillar collagen component, an acidic calcium phosphate component, and demineralized bone. 2. The composition of claim 1 wherein the fibrillar collagen component is obtained from a natural source. 3. The composition of claim 2 wherein the fibrillar collagen component is obtained from the group consisting of dermis, tendon, cartilage, or bone. 4. The composition of claim 2 wherein the fibrillar collagen component is obtained from a human source. 5. The composition of claim 1 wherein the fibrillar collagen component is synthetic. 6. The composition of claim 1 wherein the fibrillar collagen component is non-immunogenic. 7. The composition of claim 1 wherein the fibrillar collagen component is crosslinked. 8. The composition of claim 7 wherein the fibrillar collagen component is crosslinked by dehydrothermal crosslinking, UV light exposure, or chemical crosslinking. 9. The composition of claim 1 wherein the fibrillar collagen component has an in vivo lifetime of up to about twelve weeks. 10. The composition of claim 1 wherein the acidic calcium phosphate is selected from the group consisting of monocalcium phosphate [Ca(H2PO4)2], calcium hydrogen phosphate [CaHPO4], and calcium pyrophosphate [2CaO.P2O5]. 11. The composition of claim 10 wherein the acidic calcium phosphate is calcium hydrogen phosphate [CaHPO4]. 12. The composition of claim 1 wherein the equilibrium solubility of calcium or phosphate ions is greater than that of a hydroxyapatite [3.33CaO.P2O5(OH)2]. 13. The composition of claim 12 wherein the equilibrium solubility of calcium or phosphate ions is at least 200 times greater than that of hydroxyapatite [3.33CaO.P2O5(OH)2]. 14. The composition of claim 1 wherein the demineralized bone comprises at least one osteoinductive protein. 15. The composition of claim 14 wherein the equilibrium solubility of the at least one osteoinductive protein in the presence of the acidic calcium phosphate component is greater than in the presence of an equi-molar quantity of a hydroxyapatite [3.33CaO.P2O5(OH)2] in the composition. 16. The composition of claim 15 wherein the equilibrium solubility of the osteoinductive protein is at least five times greater than in the presence of an equimolar quantity of hydroxyapatite [3.33CaO.P2O5(OH)2] in the composition. 17. The composition of claim 1 wherein the composition is moldable. 18. The composition of claim 1 wherein the composition is a paste. 19. The composition of claim 1 wherein the composition is a putty. 20. The composition of claim 1 wherein the composition is injectable. 21. The composition of claim 1 wherein the pH of the composition is between about 5 and about 7. 22. The composition of claim 1 comprising particles of fibrillar collagen and acidic calcium phosphate. 23. The composition of claim 22 wherein the particles comprise about 33% fibrillar collagen by weight and about 67% acidic calcium phosphate by weight. 24. The composition of claim 22 wherein the particles comprise between about 25% and about 75% fibrillar collagen by weight.
Copyright KISTI. All Rights Reserved.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.