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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0413238 (2006-04-28) |
| 등록번호 | US-8744546 (2014-06-03) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 397 |
The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based resistance domain.
1. An implantable glucose sensor for measuring a concentration of glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane system comprises a macromolecular resistance domain configured to control a flux of glucose therethrough, w
1. An implantable glucose sensor for measuring a concentration of glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane system comprises a macromolecular resistance domain configured to control a flux of glucose therethrough, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, and wherein the macromolecular resistance domain comprises at least one hydrophilic moiety and at least one hydrophobic moiety; wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L. 2. The sensor of claim 1, wherein the hydrophobic moiety is selected from the group consisting of acetyl, butyryl, propionyl, methoxy, ethoxy, and propoxy. 3. The sensor of claim 2, wherein the hydrophobic moiety is acetyl. 4. The sensor of claim 3, wherein the macromolecular resistance domain comprises less than about 35 wt. % acetyl. 5. The sensor of claim 1, wherein the hydrophilic moiety is selected from the group consisting of hydroxyl, carboxymethyl, and carboxyethyl. 6. The sensor of claim 5, wherein the hydrophilic moiety is hydroxyl. 7. The sensor of claim 6, wherein the macromolecular resistance domain comprises at least about 7 wt. % hydroxyl. 8. The sensor of claim 1, wherein the sensor is a needle sensor configured for transcutaneous insertion into the host. 9. The sensor of claim 1, wherein the sensor is configured for wholly implanting into the host. 10. The sensor of claim 1, wherein the sensor is configured for implantation into a host tissue, and wherein the resistance domain is configured to interface with the host tissue. 11. The sensor of claim 1, wherein the resistance domain is a bioprotective barrier configured to protect the sensor from cellular invasion. 12. The sensor of claim 1, wherein the membrane system is an ionizing radiation-treated membrane system. 13. An implantable glucose sensor for measuring glucose in a host, the sensor comprising an electroactive surface and a membrane system disposed thereon, wherein the membrane is configured to use oxygen from a biological fluid surrounding the membrane to catalyze a reaction of glucose and oxygen, wherein the membrane system comprises a resistance domain configured to control a flux of glucose therethrough, and wherein the resistance domain incorporates hydrophilic substituents and hydrophobic substituents to form a macromolecular structure; wherein the sensor is configured for implantation into a host, and wherein the sensor in vitro is capable of obtaining substantial linearity at glucose concentrations of from about 40 mg/dL to about 400 mg/dL at an oxygen concentration of about 0.25 mg/L. 14. The sensor of claim 13, wherein the hydrophobic substituent is selected from the group consisting of acetyl, butyryl, propionyl, methoxy, ethoxy, and propoxy. 15. The sensor of claim 13, wherein the hydrophobic substituent is acetyl. 16. The sensor of claim 15, wherein the macromolecular resistance domain comprises less than about 35 wt. % acetyl. 17. The sensor of claim 13, wherein the hydrophilic substituent is selected from the group consisting of hydroxyl, carboxymethyl, and carboxyethyl. 18. The sensor of claim 13, wherein the hydrophilic moiety is hydroxyl. 19. The sensor of claim 18, wherein the macromolecular resistance domain comprises at least about 7 wt. % hydroxyl. 20. The sensor of claim 13, wherein the sensor is a needle sensor configured for transcutaneous insertion into the host. 21. The sensor of claim 13, wherein the sensor is configured for implantation into a host tissue, and wherein the resistance domain is configured to interface with the host tissue. 22. The sensor of claim 13, wherein the resistance domain is a bioprotective barrier configured to protect the sensor from cellular invasion. 23. The sensor of claim 13, wherein the membrane system is an ionizing radiation-treated membrane system.
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