초록 ▼

The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer imm

The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.

대표청구항 ▼

1. A method for the immunotherapy treatment of a subject with cancer, comprising: (a) identifying whether the subject is suitable for immunotherapy, the identifying comprising providing a tissue sample from the subject, which contains test cells, wherein the test cells comprise cancer cells and/or t

1. A method for the immunotherapy treatment of a subject with cancer, comprising: (a) identifying whether the subject is suitable for immunotherapy, the identifying comprising providing a tissue sample from the subject, which contains test cells, wherein the test cells comprise cancer cells and/or tumor-infiltrating leukocytes, and assessing the proportion of test cells in the tissue sample that express B7-H1, the identification being made if <10% of the cancer cells express B7-H1 and/or if an adjusted expression score of the tumor-infiltrating leukocytes is <100; and(b) administering an agent for immunotherapy to the subject,wherein said cancer is renal cell carcinoma, and wherein said agent for immunotherapy is interleukin-2. 2. The method of claim 1, wherein the subject is a human. 3. The method of claim 1, wherein said assessing comprises contacting said tissue sample with an antibody that specifically binds to B7-H1 polypeptide.