IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0821237
(2012-05-21)
|
등록번호 |
US-8758210
(2014-06-24)
|
우선권정보 |
EP-11166874 (2011-05-20) |
국제출원번호 |
PCT/EP2012/059350
(2012-05-21)
|
§371/§102 date |
20130306
(20130306)
|
국제공개번호 |
WO2012/160018
(2012-11-29)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
19 |
초록
▼
An apparatus for performing a centrifugal field-flow fractionation is disclosed. In an embodiment of the invention, radial rotary shaft seals are used for sealing the rotating parts of the shaft for carrying out the centrifugal field-flow fractionation and the stationary parts. Furthermore, a separa
An apparatus for performing a centrifugal field-flow fractionation is disclosed. In an embodiment of the invention, radial rotary shaft seals are used for sealing the rotating parts of the shaft for carrying out the centrifugal field-flow fractionation and the stationary parts. Furthermore, a separate line is introduced for reducing the pressure differential across these seals. In such way, the driving force driving sample fluid across the seals is reduced, thereby reducing leakage.
대표청구항
▼
1. An apparatus (10) for performing a centrifugal field flow fractionation comprising: a shaft (61) having a central axis and conduits (54a/b) along said central axis for sample fluid to pass therethrough, the shaft (61) having an upstream shaft end for the sample fluid to enter into and a downstrea
1. An apparatus (10) for performing a centrifugal field flow fractionation comprising: a shaft (61) having a central axis and conduits (54a/b) along said central axis for sample fluid to pass therethrough, the shaft (61) having an upstream shaft end for the sample fluid to enter into and a downstream shaft end for the sample fluid to exit from the shaft (61),the shaft (61) carrying a rotor (10a) between the upstream and the downstream shaft ends and being rotatably supported in bearing blocks (24a/b) at both said shaft ends so that the rotor (10a) and the shaft (61) are rotatable about the axis,a field flow fractionation channel (13) on the rotor (10a), the field flow fractionation channel (13) being configured to let the sample fluid pass therethrough and having an upstream channel end for the sample fluid to enter into the channel and a downstream channel end for the sample fluid to exit from the channel (13), the upstream channel end being connectable in a fluid-tight manner to a conduit (54a) at the upstream shaft end and the downstream channel end being connectable in a fluid-tight manner to a conduit (54b) at the downstream shaft end,an upstream end cap (28a) which fits over the upstream shaft end and can be attached to the bearing block (24a) at the upstream shaft end and a downstream end cap (28b) which fits over the downstream shaft end and can be attached to the bearing block (24b) at the downstream shaft end,the upstream cap end (28a) and the downstream end cap (28b) each having a terminal (40a/b) for connection to a line for the sample fluid, the upstream end cap (28a) and the downstream end cap (28b) each having a further terminal (44a/b) for connection to a line for flushing fluid,the upstream end cap (28a) and the downstream end cap (28b) each having a second recess (37a/b) and a first recess (39a/b), each of the second recesses (37a/b) being for accommodation of a second radial rotary shaft seal (36a/b) for sealing the end cap (28a/b) against the shaft (61) and each of the first recesses (39a/b) being for accommodation of a first radial rotary shaft seal (38a/b) for sealing the end cap (28a/b) against the shaft (61),each of the second recesses (37a/b) on one side of its second radial rotary shaft seal (36a/b) being in fluid communication with the terminal (40a/b) for connection to the sample fluid line and on the other side of its second radial rotary shaft seal (36a/b) being in fluid communication with the terminal (40a/b) for connection to the flushing fluid line, and each of the first recesses (39a/b) on one side of its first radial rotary shaft seal (38a/b) being in fluid communication with the terminal (44a/b) for connection to the flushing fluid line, so that both sides of the second radial rotary shaft seals (36a/b) are subjected to fluids. 2. The apparatus (10) according to claim 1, wherein the pressure differential across the second radial rotary shaft seals (36a/b) is determined by the difference in pressure arising from 4 to 7 bar sample pressure and about 200 mbar flushing pressure of the sample fluid and the flushing fluid at the respective end cap (28a/b), and the flushing fluid is pressurized so as to control the pressure differential. 3. The apparatus (10) according to claim 1, wherein the terminals (40a/b) for connection to the line for the sample fluid are aligned with the central axis when the end caps (28a/b) are attached. 4. The apparatus (10) according to claim 3, wherein at least one of the conduits (54a/b) along said central axis of the shaft (61) has a diameter sufficiently large for the sample fluid line to extend through the terminal (40a/b) and into the conduit (54a/b). 5. The apparatus (10) according to claim 4, wherein the sample fluid line is inserted into the conduit (54a/b). 6. The apparatus (10) according to claim 1, wherein the second recesses (37a/b) are axially remote from the bearing block (24a/b) and the first recesses (39a/b) are axially closer to the bearing block (24a/b). 7. The apparatus (10) according to claim 1, wherein the first and/or second radial rotary shaft seals (26a/b, 38a/b) are free of spiral grooves or helices. 8. Previously Presented) The apparatus (10) according to claim 1, wherein each of the first recesses (29a/b) on the other side of its first radial rotary shaft seal (38a/b) is in fluid communication with a further terminal (42a/b) for connection to a drain fluid line. 9. The apparatus (10) according to claim 1, wherein the upstream end cap (28a) and the downstream end cap (28b) are of the same design. 10. A method of performing a centrifugal field flow fractionation, the method comprising the following steps: providing a flow of sample fluid to an upstream terminal (40a) of an apparatus (10) for performing a centrifugal field flow fractionation,passing the flow of sample fluid through a field flow fractionation channel (13), conveying the flow of sample fluid away from a downstream terminal (40b) of the apparatus (10),providing a flow of flushing fluid to an upstream terminal (44a) of the apparatus (10),providing a flow of flushing fluid to a downstream terminal (44b) of the apparatus (10),sealing the flow of sample fluid from the flow of flushing fluid at the upstream terminal (40a) by means of a radial seal (36a), andsealing the flow of sample fluid from the flow of flushing fluid at the downstream terminal (40b) by means of a radial seal (36b). 11. A method according to claim 10, further comprising the step of pressurizing the flushing fluids so as to reduce the difference in pressures of the flushing fluid and of the sample fluid at the upstream terminal (40a) and the difference in pressures of the flushing fluid and of the sample fluid at the downstream terminal (40b). 12. A method according to claim 10, wherein the step of providing the flow of sample fluid to the upstream terminal (40a) of the apparatus (10) for performing a centrifugal field flow fractionation and/or the step of conveying the flow of sample fluid away from the downstream terminal (40b) of the apparatus (10) comprises introducing a sample fluid line into a conduit (54a/b) in a shaft (61) of the apparatus (10), the conduit (54a/b) extending along a central axis of the shaft (61).
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