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Catheter connectors, systems, and methods of use in which a catheter is attached to a connector such that the catheter is retained on the connector by inward radial compression between an outer surface of a hollow pin located within the catheter and a collet fitted over the portion of the catheter c

Catheter connectors, systems, and methods of use in which a catheter is attached to a connector such that the catheter is retained on the connector by inward radial compression between an outer surface of a hollow pin located within the catheter and a collet fitted over the portion of the catheter containing the pin. The collet may be moved from an unlocked position to a locked position by axial displacement of the collet along a longitudinal axis of the connector.

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1. A catheter connection system comprising: a connector pin comprising a first end configured for insertion into a lumen of a catheter, the connector pin comprising an outer surface;a coupling sleeve configured to surround at least a portion of the catheter that contains the connector pin, wherein a

1. A catheter connection system comprising: a connector pin comprising a first end configured for insertion into a lumen of a catheter, the connector pin comprising an outer surface;a coupling sleeve configured to surround at least a portion of the catheter that contains the connector pin, wherein an outer surface of the sleeve comprises radially protruding elements; anda tubular collet surrounding an end of the sleeve, the collet movable along a longitudinal axis of the sleeve from an unlocked position to a locked position, wherein the collet comprises an outer ring; an inner ring; and an annular space between the inner and outer rings, and wherein the inner ring comprises one or more segments that deflect inwardly to radially compress the catheter against the outer surface of the pin when the collet is in the locked position. 2. The system of claim 1, wherein the end of the sleeve is received within the annular space of the collet when the collet is in the locked position. 3. The system of claim 2, wherein the sleeve defines an inner surface comprising a tapered surface operable to slide along the one or more segments of the inner ring as the collet is moved from the unlocked position to the locked position. 4. The system of claim 1, wherein the connector pin is fixed within the sleeve. 5. The system of claim 1, wherein the radially protruding elements comprise tabs that engage openings formed in the collet to secure the collet in the locked position. 6. The system of claim 1, wherein the radially protruding elements comprise guide tabs configured to slide within slots in the collet. 7. The system of claim 1, wherein the one or more segments of the inner ring comprises four segments. 8. The system of claim 1, wherein the collet defines a passageway configured to receive the catheter and align the catheter with the first end of the connector pin. 9. The system of claim 1, wherein the connector pin comprises a tapered section transitioning the outer surface of the pin from a first diameter at the first end, to a second, larger diameter towards a center of the pin. 10. The system of claim 1, wherein the connector pin comprises one or more circumferential barbs located proximate the first end. 11. The system of claim 1, wherein the pin comprises a second end for insertion into a lumen of a second catheter. 12. A catheter connection system comprising: a connector body comprising: a tubular coupling sleeve comprising a wall defined by an inner surface and an outer surface, wherein the inner surface diverges to form an enlarged mouth at an end of the sleeve, wherein the inner surface of the mouth further defines a tapered surface that diverges towards the end of the sleeve; anda tubular connector pin fixed relative to the inner surface of the sleeve such that an end of the pin extends outwardly into or beyond the enlarged mouth;a catheter defining a lumen configured to receive the end of the connector pin therein, wherein a first end of the catheter is located within the enlarged mouth of the sleeve when the end of the connector pin is received within the lumen of the catheter; anda tubular collet configured to both: surround a portion of the catheter containing the connector pin; and interlock with the sleeve, the collet movable along a longitudinal axis of the sleeve from an unlocked position to a locked position, wherein the collet comprises an outer ring; an inner ring; and an annular space between the inner and outer rings, and wherein the end of the sleeve is received within the annular space when the collet is in the locked position. 13. The system of claim 12, wherein the tapered surface is configured to slide along the inner ring and deflect the inner ring radially inwardly as the collet is moved to the locked position. 14. The system of claim 12, wherein an outer surface of the pin comprises a tapered section. 15. The system of claim 12, wherein an outer surface of the pin comprises a circumferential barb. 16. The system of claim 12, wherein the connector pin comprises a second end extending into an enlarged mouth at a second end of the sleeve, and wherein the system further comprises: a second catheter defining a lumen configured to receive the second end of the pin; anda second collet associated with the second end of the sleeve. 17. A therapeutic substance delivery system comprising: an implantable medical device;a delivery catheter for coupling with the medical device; anda catheter connector comprising: a connector pin comprising a terminal end configured for insertion into a lumen of the delivery catheter, the connector pin comprising an outer surface;a coupling sleeve configured to surround at least a portion of the delivery catheter that contains the connector pin, wherein an outer surface of the sleeve comprises radially protruding elements; anda tubular collet surrounding an end of the sleeve, the collet movable along a longitudinal axis of the sleeve from an unlocked position to a locked position, wherein the collet comprises an outer ring; an inner ring; and an annular space between the inner and outer rings, and wherein the inner ring comprises one or more segments that deflect inwardly to radially compress the delivery catheter against the outer surface of the pin when the collet is in the locked position. 18. The system of claim 17, wherein the catheter connector forms part of the medical device. 19. The system of claim 17, wherein the catheter connector couples the delivery catheter to a therapy catheter. 20. A method of connecting a catheter to a tubular connector pin, the method comprising: inserting an end of the connector pin into a lumen of the catheter, the connector pin surrounded by a coupling sleeve radially spaced-apart from the end of the connector pin;sliding a tubular collet over the sleeve from an unlocked position to a locked position, wherein the collet comprises an outer ring; an inner ring; and an annular space between the inner and outer rings, and wherein the inner ring comprises one or more deflectable segments;locating an end of the sleeve in the annular space of the collet;contacting the inner ring of the collet with an inner surface of the sleeve;deflecting the one or more deflectable segments radially inwardly;compressing the catheter against an outer surface of the pin; andengaging a tab associated with an outer surface of the sleeve with an opening associated with the collet when the collet reaches the locked position. 21. The method of claim 20, wherein contacting the inner ring of the collet with the inner surface of the sleeve comprises contacting the inner ring with a tapered surface of the inner surface of the sleeve.