Influenza hemagglutinin antibodies, compositions and related methods
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/42
A61K-051/00
A61K-036/14
출원번호
US-0498946
(2010-09-29)
등록번호
US-8784819
(2014-07-22)
국제출원번호
PCT/US2010/050693
(2010-09-29)
§371/§102 date
20120830
(20120830)
국제공개번호
WO2011/041391
(2011-04-07)
발명자
/ 주소
Yusibov, Vidadi
Mett, Vadim
Chichester, Jessica
Goldschmidt, Lauren
출원인 / 주소
iBio Inc.
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
2인용 특허 :
80
초록
Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.
대표청구항▼
1. An isolated monoclonal antibody that binds hemagglutinin, wherein the antibody has the ability to inhibit hemagglutination, and wherein the antibody is selected from the group consisting of: an antibody comprising the light chain variable region amino acid sequence set forth in amino acids 1-97 o
1. An isolated monoclonal antibody that binds hemagglutinin, wherein the antibody has the ability to inhibit hemagglutination, and wherein the antibody is selected from the group consisting of: an antibody comprising the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, and the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78; andan antibody comprising the light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81, and the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80. 2. The antibody of claim 1, wherein the antibody comprises the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, and the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78. 3. The antibody of claim 1, wherein the antibody comprises the light chain variable region amino set forth in amino acids 1-96 of SEQ ID NO:81, and the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80. 4. An antibody that binds hemagglutinin, wherein the antibody has the ability to inhibit hemagglutination, and wherein the antibody is selected from the group consisting of: an antibody comprising the light chain amino acid sequence set forth in SEQ ID NO:79, and the heavy chain amino acid sequence set forth in SEQ ID NO:78; andan antibody comprising the light chain amino acid sequence set forth in SEQ ID NO:81, and the heavy chain amino acid sequence set forth in SEQ ID NO:80. 5. The antibody of claim 4, wherein the antibody comprises the light chain amino acid sequence set forth in SEQ ID NO:79 and the heavy chain amino acid sequence set forth in SEQ ID NO:78. 6. The antibody of claim 4, wherein the antibody comprises the light chain amino acid sequence set forth in SEQ ID NO:81 and the heavy chain amino acid sequence set forth in SEQ ID NO:80. 7. An antigen-binding fragment of an antibody that binds hemagglutinin and has the ability to inhibit hemagglutination, wherein the antigen-binding fragment comprises: the light chain variable region amino acid sequence set forth in amino acids 1-97 of SEQ ID NO:79, and the heavy chain variable region amino acid sequence set forth in amino acids 1-115 of SEQ ID NO:78; orthe light chain variable region amino acid sequence set forth in amino acids 1-96 of SEQ ID NO:81, and the heavy chain variable region amino acid sequence set forth in amino acids 1-112 of SEQ ID NO:80;wherein the antigen-binding fragment is an scFv, Fv, Fab′, Fab, diabody, linear antibody, or F(ab′)2 antigen-binding fragment. 8. The antigen-binding fragment of claim 7, wherein the antigen-binding fragment is a univalent fragment, or a single domain antibody. 9. The antibody of claim 1, wherein the antibody is a human, humanized, or part-human antibody. 10. The antibody of claim 1, wherein the antibody is a recombinant antibody. 11. The antibody of claim 1, wherein the antibody is produced in a plant. 12. The antibody of claim 1, wherein the antibody is operatively attached to a biological agent, an imaging agent, a detectable agent, or a diagnostic agent. 13. The antibody of claim 12, wherein the antibody is operatively attached to an agent that cleaves a substantially inactive prodrug to release a substantially active drug. 14. The antibody of claim 13, wherein the drug is an anti-influenza agent. 15. The antibody of claim 12, wherein the antibody is operatively attached to an anti-viral agent. 16. The antibody of claim 12, wherein the antibody is operatively attached to the biological agent as a fusion protein prepared by expressing a recombinant vector that comprises, in the same reading frame, a DNA segment encoding the antibody operatively linked to a DNA segment encoding the biological agent. 17. The antibody of claim 12, wherein the antibody is operatively attached to the biological agent via a biologically releasable bond or selectively cleavable linker. 18. The antibody of claim 12, wherein the antibody is operatively attached to an X-ray detectable compound, a radioactive ion or a nuclear magnetic spin-resonance isotope. 19. The antibody of claim 12, wherein the antibody is operatively attached to biotin, avidin or to an enzyme that generates a colored product upon contact with a chromogenic substrate. 20. A pharmaceutical composition comprising the antibody of claim 1, and a pharmaceutically acceptable carrier. 21. The composition of claim 20, wherein the composition is formulated for parenteral or topical administration. 22. The composition of claim 20, wherein the antibody is a recombinant, plant-produced antibody. 23. The composition of claim 20, wherein the pharmaceutically acceptable composition is an encapsulated or liposomal formulation.
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Bendig Mary M. (London GBX) Kettleborough Catherine A. (Herts GBX) Saldanha Jose (Middlesex GBX), Humanized and chimeric anti-epidermal growth factor receptor monoclonal antibodies.
Queen Cary L. (Los Altos CA) Co Man Sung (Cupertino CA) Schneider William P. (Mountain View CA) Landolfi Nicholas F. (Milpitas CA) Coelingh Kathleen L. (San Francisco CA) Selick Harold E. (Belmont CA, Humanized immunoglobulins.
Mizzen, Lee A.; Chu, N. Randall; Wu, Huacheng Bill, Immune responses against HPV antigens elicited by compositions comprising an HPV antigen and a stress protein or an expression vector capable of expression of these proteins.
Lilley Stephen J. (Sawston GBX) Taylor Hugh F. (Sawston GBX) Theobald David R. (Huntingdon GBX) Carlson Craig J. (Andover MA) Rosen David I. (Arlington MA) Johnson Thomas R. (Milford NH), Medical injection system and method, gas spring thereof and launching device using gas spring.
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Barbas Carlos F. (San Diego CA) Burton Dennis R. (La Jolla CA) Lerner Richard A. (La Jolla CA), Methods for producing antibody libraries using universal or randomized immunoglobulin light chains.
Johnson Kevin Stuart,GBX ; Winter Gregory Paul,GBX ; Griffiths Andrew David,GBX ; Smith Andrew John Hammond,GBX ; Waterhouse Peter Michael,AUX, Methods for producing members of specific binding pairs.
Robinson Randy R. (Los Angeles CA) Liu Alvin Y. (Oceanside CA) Horwitz Arnold H. (Los Angeles CA) Better Marc (Los Angeles CA) Wall Randolph (Sherman Oaks CA) Lei Shau-Ping (Los Angeles CA) Wilcox Ga, Modular assembly of antibody genes, antibodies prepared thereby and use.
Robinson Randy R. (Los Angeles CA) Liu Alvin Y. (Oceanside CA) Horwitz Arnold H. (Los Angeles CA) Better Marc (Los Angeles CA) Wall Randolph (Sherman Oaks CA) Lei Shau-Ping (Los Angeles CA) Wilcox Ga, Modular assembly of antibody genes, antibodies prepared thereby and use.
McKinnon ; Jr. Charles N. (Laguna Niguel CA) Peterson Steven F. (West Linn OR) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection device.
Peterson Steven F. (West Linn OR) McKinnon ; Jr. Charles N. (Laguna Niguel CA) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection methods and device.
Donson Jon (Davis CA) Dawson William O. (Winter Haven FL) Granthan George L. (Riverside CA) Turpen Thomas H. (Vacaville CA) Turpen Ann M. (Vacaville CA) Garger Stephen J. (Vacaville CA) Grill Laurenc, Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes.
Queen Cary L. (Los Altos CA) Schneider William P. (Mountain View CA) Selick Harold E. (Belmont CA), Polynucleotides encoding improved humanized immunoglobulins.
Garger, Stephen J.; Holtz, R. Barry; McCulloch, Michael J.; Turpen, Thomas H., Process for isolating and purifying proteins and peptides from plant sources.
Surani Azim M. (Cambridge GB3) Neuberger Michael S. (Cambridge GB3) Bruggemann Marianne (Cambridge GB3), Production of antibodies from transgenic animals.
Hoogenboom Hendricus R. J. M. (Cambridge GBX) Baier Michael (Frankfurt DEX) Jespers Laurent S. A. T. (Tervuren BEX) Winter Gregory P. (Cambridge GBX), Production of chimeric antibodies - a combinatorial approach.
Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
Pedersen Jan T. (Bath GBX) Searle Stephen M. J. (Bath GBX) Rees Anthony R. (Bath GBX) Roguska Michael A. (Ashland MA) Guild Braydon C. (Concord MA), Resurfacing of rodent antibodies.
Lonberg Nils (San Francisco CA) Kay Robert M. (San Francisco CA), Transgenic non-human animals capable of producing heterologous antibodies of various isotypes.
Lonberg Nils (San Francisco CA) Kay Robert M. (San Francisco CA), Transgenic non-human animals capable of producing heterologous antibodies of various isotypes.
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