최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0976704 (2010-12-22) |
등록번호 | US-8784863 (2014-07-22) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 2 인용 특허 : 365 |
The present invention is directed to compositions having at least one neocartilage particle, juvenile cartilage particle or a combination thereof and a matrix, and methods and devices that include the compositions.
1. A cartilage treatment kit comprising: cadaveric, allogenic human juvenile cartilage particles including viable chondrocytes;biocompatible chondro-conductive/inductive matrix;a biocompatible storage solution; anda sealed, sterile container in which the cartilage particles and storage solution are
1. A cartilage treatment kit comprising: cadaveric, allogenic human juvenile cartilage particles including viable chondrocytes;biocompatible chondro-conductive/inductive matrix;a biocompatible storage solution; anda sealed, sterile container in which the cartilage particles and storage solution are disposed;wherein the container is positioned within a sealed, sterile pouch having a hollow interior. 2. The kit of claim 1, wherein the container comprises: a tray having a lip surrounding a receptacle; anda removable cover attached to the lip of the tray for sealing the receptacle. 3. The kit of claim 1, wherein the storage solution comprises at least one preservative. 4. The kit of claim 3, wherein the preservative comprises a buffer, an amino acid, a sugar, a salt, a mineral or combinations thereof. 5. The kit of claim 1, wherein the juvenile cartilage particles are from cadaveric juvenile donors less than fifteen years of age. 6. The kit of claim 5, wherein the juvenile cartilage particles are from cadaveric juvenile donors less than two years of age. 7. The kit of claim 5, wherein the juvenile cartilage particles are from cadaveric juvenile donors from about 20 weeks to about 13 years of age. 8. The kit of any one of claim 1, 3 or 5, wherein the kit comprises juvenile cartilage particles having a dimension from about one to about three millimeters. 9. The kit of claim 5, wherein the juvenile cartilage particles are from a cartilage site scored in a grid pattern. 10. The kit of claim 9, wherein the grid pattern is a square grid pattern. 11. The kit of any one of claim 1, 3 or 5, wherein the kit comprises juvenile cartilage particles range in size from about 1 to about 27 mm3. 12. The kit of any one of claim 1, 3 or 5, wherein the juvenile cartilage particles comprise at least 1×106 chondrocytes. 13. The kit of any one of claim 1, 3 or 5, comprising at least 60 mg of juvenile cartilage particles. 14. The kit of any one of claim 1, 3 or 5, wherein the cartilage particles comprise articular cartilage. 15. The kit of claim 14, wherein the articular cartilage is harvested from a femoral condyle a tibial plateau or an interior surface of a patella. 16. The kit of claim 1, wherein the cartilage is distributed throughout substantially all of the matrix or just a portion of the matrix. 17. The kit of claim 1, wherein the chondro-conductive/inductive matrix comprises fibrinogen, fibrinogen/thrombin, albumin, in-situ forming poly(ethylene glycol) (PEG) hydrogel, fibrin/hyaluronate, fibrin/collagen/hyaluronate, PEG/hyaluronate, PEG/collagen, plasma and protein-based adhesives and sealants, natural adhesives and sealants and any combination thereof. 18. The kit of claim 1 further comprising an osteo-conductive matrix. 19. The kit of claim 18, wherein the osteo-conductive matrix comprises fibrinogen, fibrinogen/thrombin, fibrin/tri-calcium phosphate, fibrin/collagen/tri-calcium phosphate, fibrin/hyaluronate/tri-calcium phosphate, in-situ forming PEG hydrogel sealants, PEG/tri-calcium phosphate, PEG/collagen, demineralized bone matrix, and any combination thereof. 20. The kit of claim 18 further comprising an associated matrix comprising collagen, polylactic acid (PLA), polyglycolic acid (PGA), and combinations thereof.
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