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Long term drug delivery devices with polyurethane-based polymers and their manufacture 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-002/00
  • A61K-009/00
출원번호 US-0892946 (2013-05-13)
등록번호 US-8784865 (2014-07-22)
발명자 / 주소
  • Kuzma, Petr
  • Quandt, Harry
출원인 / 주소
  • Endo Pharmaceuticals Solutions Inc.
대리인 / 주소
    RatnerPrestia
인용정보 피인용 횟수 : 0  인용 특허 : 33

초록

This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in

대표청구항

1. An implantable drug delivery device, comprising a polyurethane-based polymer having polyether-based polyol segments represented by the formula —[O—(CH2)n]x—O—, said polyurethane-based polymer configured to provide a cylindrically shaped reservoir, wherein the reservoir is sealed after being charg

이 특허에 인용된 특허 (33)

  1. Chen Guohua ; Lautenbach Scott ; Dionne Keith ; Hom Lawton, Beneficial agent delivery system with membrane plug and method for controlling delivery of beneficial agents.
  2. Szycher Michael (Lynnfield MA) Reed Andrew M. (Arvada CO), Biostable polyurethane products.
  3. Zimmerman Ronald E. (Danville IN) Burck Philip J. (Indianapolis IN) Dunn Richard L. (Birmingham AL), Contraceptive device.
  4. Brem Henry (Lutherville MD) Langer Robert S. (Newton MA) Domb Abraham J. (Efrat ILX), Controlled local delivery of chemotherapeutic agents for treating solid tumors.
  5. Runkel, Richard A.; Lee, Jung-Chung, Controlled release subcutaneous implant.
  6. Blair E. Allan (Pennington NJ), Desalination process.
  7. Mamajek Ronald C. (Glenside PA) Moyer Ernest S. (Grafton WV), Drug-dispensing device and method.
  8. Brill Frank D. (Norridge IL), Dual reservoir coffee urn.
  9. Szycher Michael (Lynnfield MA), Extrudable polyurethane for prosthetic devices prepared from a diisocyanate, a polytetramethylene ether polyol, and 1,4-.
  10. Bess, William S.; Kulkarni, Neema; Ambike, Suhas H.; Ramsay, Michael P., Fast dissolving orally consumable films containing a taste masking agent.
  11. Bess,William S.; Kulkarni,Neema; Ambike,Suhas H.; Ramsay,Michael P., Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1.
  12. Johnston Christian W. (Neshanic Station NJ) Teffenhart John M. (Neshanic Station NJ), Hydrophilic carboxy polyurethanes.
  13. Hudgin Donald Edward (Princeton Junction NJ) Blair Edgar Allan (Cranbury NJ), Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles.
  14. Gooberman Lance L. ; Brewer Colin,GBX, Improvements to rapid opioid detoxification.
  15. Kuzma, Petr; Quandt, Harry, Long term drug delivery devices with polyurethane based polymers and their manufacture.
  16. Moro Daniel G. (Randolph NJ) Kuzma Petr (Monmouth Junction NJ) Quandt Harry (North Middletown NJ), Manufacture of water-swellable hydrophilic articles and drug delivery devices.
  17. Szycher Michael (Lynnfield MA) Rolfe Jonathan L. (Easton MA), Medical patches and processes for producing same.
  18. Fuchs Peter (Berlin DE1) Hilmann Jurgen (Berlin DE1), Medicament carriers in the form of film having active substance incorporated therein.
  19. Nelson Timothy S. ; Bergan Matthew A., Method and apparatus for administering analgesics, and method for making same device.
  20. Lee Clarence C. (Lilburn GA), Method and device for long-term delivery of drugs.
  21. Aguadisch Louis Michele Jacques,FRX ; Colas Andre Rudolf Louis,FRX, Method for manufacturing a controlled-release device.
  22. Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
  23. Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
  24. Chen Guohua ; Lautenbach Scott D. ; Dionne Keith E. ; Jordan Scott D. ; Berry Steve A. ; Rodenberger Craig I. ; Ayer Rupal, Osmotic delivery system, osmotic delivery system semimpermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems.
  25. Higashi Kiyotsugu (Nara JPX) Kametaka Shigeru (Osaka JPX) Izumi Reiko (Osaka JPX) Morisaki Katsuhiko (Nara JPX) Hayashi Shin\ichi (Osaka JPX), Pharmaceutical composition for treating periodontal.
  26. Meijs Gordon Francis,AUX ; Gunatillake Pathiraja Arachchillage,AUX ; McCarthy Simon John,AUX, Polysiloxane-containing polyurethane elastomeric compositions.
  27. Szycher ; Michael, Polyurethane elastomer for heart assist devices.
  28. Kuzma Petr (Monmouth Junction NJ) Moro Daniel G. (Randolph NJ) Quandt Harry (North Middletown NJ), Preparation of homogeneous hydrogel copolymers.
  29. Szycher Michael (Lynnfield MA), Process for forming an optically clear polyurethane lens or cornea.
  30. Trudell Leonard A. (East Grenwich RI) Whittemore Anthony D. (Sherborn MA), Prosthesis of foam polyurethane and collagen and uses thereof.
  31. Lothar W. Kleiner ; Robert M. Gale ; Randall G. Berggren ; Gilbert T. Tong ; Guohua Chen ; Keith E. Dionne ; Paul R. Houston, Rate controlling membranes for controlled drug delivery devices.
  32. Peery John R. ; Dionne Keith E. ; Eckenhoff James B. ; Landrau Felix A. ; Lautenbach Scott D. ; Magruder Judy A. ; Wright Jeremy C., Sustained delivery of leuprolide using an implantable system.
  33. Ward Robert S. ; White Kathleen A., Systems for premeating molecules of predetermined molecular weight range.
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