[특허]Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition

The Invention Science Fund I, LLC

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특허 상세정보

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Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G06F-019/00 A61B-017/3203 G01N-033/574 A61B-017/00 A61K-009/14 A61B-018/02 A61B-019/00
미국특허분류(USC)	702/019; 606/167; 606/131
출원번호	US-0290676 (2008-10-31)
등록번호	US-8788211 (2014-07-22)
발명자 / 주소	Boyden, Edward S. Cook, Daniel B. Hyde, Roderick A. Leuthardt, Eric C. Myhrvold, Nathan P. Sweeney, Elizabeth A. Wood, Jr., Lowell L.
출원인 / 주소	The Invention Science Fund I, LLC
인용정보	피인용 횟수 : 2 인용 특허 : 173

초록

Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

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1. A system, comprising: a computing device and a plurality of instructions that when executed on the computing device cause the computing device to generate output information, and direct a remote controlled delivery device to administer a plurality of frozen particle compositions in sequential order to a subject; the plurality of frozen particle compositions including at least two subsets of frozen particle compositions including at least one tracer agent, and different therapeutic agents, wherein the therapeutic agents include one or more of an anti-tumor agent, antimicrobial agent, anti-viral agent, analgesic, anesthetic, anti-inflammatory agent, vaccine, chemical debridement agent, immunogen, antigen, hormone, enzyme, cytokine, or anti-coagulant; the plurality of instructions including but not limited to:one or more instructions for comparing information regarding at least one aspect of cellular or tissue abrasion or ablation of at least one biological tissue of at least one subject as detected by the at least one tracer agent and information regarding at least one clinical outcome following receipt by the at least one subject of at least one subset of frozen particle composition;the output information being based on the comparison; and including at least one of a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered, a code indicative of at least one therapeutic agent delivered; a code indicative of at least one diagnostic agent delivered; a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject; a code indicative of at least one dispersion or location of at least one delivered agent; a code indicative of at least one detection material delivered; a code indicative of the depth of penetration of a delivered agent; andfurther directing the remote controlled delivery device to adjust the administration of the sequential order of one or more subset of frozen particle compositions based on the comparison and real-time feedback control as determined by detection of the at least one tracer agent. 2. The system of claim 1, further including one or more instructions for determining at least one statistical correlation. 3. The system of claim 2, further including one or more instructions for using one or more of the at least one correlation to predict at least one clinical outcome regarding at least one second subject. 4. The system of claim 3, wherein the at least one second subject has not received at least one frozen particle composition. 5. The system of claim 3, further including one or more instructions for predicting at least one clinical outcome involving the at least one second subject, wherein the at least one second subject is a plurality of people; and segregating subject identifiers associated with the plurality of people in reference to the predicted at least one clinical outcome. 6. The system of claim 3, wherein the at least one second subject is a plurality of people; and further including determining the eligibility of the at least one second subject for the at least one clinical trial. 7. The system of claim 1, further including one or more instructions for counting the occurrence of at least one clinical outcome. 8. The system of claim 1, wherein the information regarding at least one aspect of cellular or tissue abrasion or ablation includes information regarding quantity of cells or tissue removed or destroyed. 9. The system of claim 1, wherein the information regarding at least one aspect of cellular or tissue abrasion or ablation includes information regarding at least one dimension of cellular, tissue, or other material removal or destruction. 10. The system of claim 9, wherein the information regarding at least one dimension of cellular, tissue, or other material removal or destruction includes information regarding at least one depth, width, or breadth of cellular, tissue, or other material removal or destruction. 11. The system of claim 1, wherein the information regarding at least one aspect of cellular or tissue abrasion or ablation includes information regarding two or more subjects with one or more common attributes. 12. The system of claim 1, wherein the information regarding at least one aspect of cellular or tissue abrasion or ablation includes information regarding at least one cellular or tissue source. 13. The system of claim 12, wherein the information regarding at least one tissue source includes information regarding at least one abnormal cellular or tissue source. 14. The system of claim 12, wherein the information regarding at least one cellular or tissue source includes information regarding at least one type of cell or tissue. 15. The system of claim 1, wherein at least one subset of frozen particle compositions further includes at least one of polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer's solution, lactated Ringer's solution, Hartmann's solution, acetated Ringer's solution, phosphate buffered solution, TRIS-buffered saline solution, Hank's balanced salt solution, Earle's balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, diethyl ether, nitrogen, carbon dioxide, hydrogen oxide, helium, neon, xenon, krypton, chlorine, bromine, oxygen, air or argon. 16. The system of claim 1, wherein at least one frozen particle composition of the plurality includes at least one major dimension of approximately one centimeter or less, approximately one millimeter or less, approximately one micrometer or less, approximately one nanometer or less, or any value therebetween. 17. The system of claim 1, wherein at least one frozen particle composition of the plurality includes one or more reinforcement agents. 18. The system of claim 1, wherein at least one frozen particle composition of the plurality includes one or more explosive materials. 19. The system of claim 1, wherein the receipt by the at least one subject of at least one frozen particle composition is pursuant to at least one clinical trial. 20. The system of claim 1, further including one or more instructions for creating at least one inclusion criterion and at least one exclusion criterion for a clinical trial involving at least one frozen particle composition of the plurality. 21. The system of claim 1, further including one or more instructions for suggesting the inclusion of one or more of the at least one subject in at least one clinical trial. 22. The system of claim 1, further including one or more instructions for suggesting the exclusion of one or more of the at least one subject in at least one clinical trial. 23. The system of claim 1, wherein the at least one biological tissue includes at least one of a tooth, bone, connective tissue, adipose tissue, skin, scalp, hair, nail, nail bed, teeth, eye, tongue, tonsil, adenoid, liver, pancreas, stomach, blood vessel, heart, lung, brain, breast, kidney, bladder, urethra, ureter, gall bladder, uterus, ovary, oviduct, prostate, large intestine, small intestine, esophagus, oral cavity, nasal cavity, otic cavity, tumor, neoplastic tissue, or muscle tissue. 24. The system of claim 1, wherein the at least one subject includes at least one of a reptile, mammal, amphibian, bird, or fish. 25. The system of claim 24, wherein the at least one subject includes at least one of a pet, livestock, undomesticated herd animal, wild animal, or product animal. 26. The system of claim 24, wherein the at least one subject includes at least one of a human, sheep, goat, frog, dog, cat, rat, mouse, vermin, monkey, duck, horse, cow, pig, chicken, shellfish, fish, turkey, llama, alpaca, bison, wolf, fox, coyote, deer, rabbit, guinea pig, yak, chinchilla, mink, reindeer, raccoon, deer, elk, camel, donkey, or mule. 27. The system of claim 1, wherein the computing device is configured to communicate with a frozen particle composition generating apparatus. 28. A system, comprising: a computing device and a plurality of instructions that when executed on the computing device cause the computing device to generate output information, and direct a remote controlled delivery device to administer a plurality of frozen particle compositions in sequential order to a subject; the plurality of instructions including but not limited to:one or more instructions for comparing information regarding at least one aspect of cellular or tissue abrasion or ablation of at least one biological tissue of at least one subject and information regarding at least one frozen particle composition involving the at least one biological tissue of at least one subject; the plurality of frozen particle compositions including at least two subsets having different therapeutic agents and at least one tracer agent, the therapeutic agents including one or more of an anti-tumor agent, antimicrobial agent, anti-viral agent, analgesic, anesthetic, anti-inflammatory agent, vaccine, chemical debridement agent, immunogen, antigen, hormone, enzyme, cytokine, or anti-coagulant; andone or more instructions for applying one or more comparisons to information regarding at least one aspect of cellular or tissue abrasion or ablation regarding a plurality of people as determined by detection of the at least one tracer agent;the output information being based on the comparison and real-time feedback control based on the detection of the at least one tracer agent, and includes at least one of a comparison code, a comparison plot, a diagnostic code, a treatment code, a test code, a code indicative of at least one treatment received, a code indicative of at least one prescribed treatment step, a code indicative of at least one vaccination delivered, a code indicative of at least one therapeutic agent delivered; a code indicative of at least one diagnostic agent delivered; a code indicative of at least one interaction of a delivered agent and at least one biological or chemical agent in the subject; a code indicative of at least one dispersion or location of at least one delivered agent; a code indicative of at least one detection material delivered; a code indicative of the depth of penetration of a delivered agent; andfurther directing the remote controlled delivery device to adjust the sequential order administration of the at least one frozen particle composition based on the comparison and detection of the at least one tracer agent. 29. The system of claim 28, further including one or more instructions for segregating subject identifiers associated with the plurality of people in reference to at least one of the one or more applied comparisons. 30. The system of claim 28, wherein the information regarding at least one aspect of cellular or tissue abrasion or ablation includes information regarding quantity of cells or tissue removed or destroyed. 31. The system of claim 28, wherein the information regarding at least one aspect of cellular or tissue abrasion or ablation includes information regarding at least one dimension of cellular, tissue, or other material removal or destruction. 32. The system of claim 31, wherein the information regarding at least one dimension of cellular, tissue, or other material removal or destruction includes information regarding at least one depth, width, or breadth of cellular, tissue, or other material removal or destruction. 33. The system of claim 28, further including one or more instructions for segregating individual identifiers associated with the plurality of people in reference to at least one characteristic shared by two or more subjects of the plurality of people. 34. The system of claim 28, wherein the at least one biological tissue is located in at least one of in situ, in vitro, in vivo, in utero, in planta, or ex vivo. 35. The system of claim 28, wherein the plurality of frozen particle compositions includes at least one frozen particle composition with at least one of an abrasive, reinforcement agent, or explosive. 36. The system of claim 28, wherein at least one frozen particle composition of the plurality includes at least one of nitrogen, argon, helium, air, oxygen, neon, xenon, krypton, chlorine, bromine, carbon dioxide, polyethylene glycol, acetone, ethyl acetate, dimethyl sulfoxide, dimethyl formamide, dioxane, hexamethylphosphorotriamide, perfluorohydrocarbon, methanol, ethanol, tert-butyl alcohol, formic acid, hydrogen fluoride, ammonia, acetic acid, benzene, carbon tetrachloride, acetonitrile, hexane, methylene chloride, carboxylic acid, saline, Ringer's solution, lactated Ringer's solution, Hartmann's solution, acetated Ringer's solution, phosphate buffered solution, TRIS-buffered saline solution, Hank's balanced salt solution, Earle's balanced salt solution, standard saline citrate, HEPES-buffered saline, dextrose, glucose, or diethyl ether. 37. The system of claim 28, wherein the at least one biological tissue includes at least one of a tooth, bone, connective tissue, adipose tissue, skin, scalp, hair, nail, nail bed, teeth, eye, tongue, tonsil, adenoid, liver, pancreas, stomach, blood vessel, heart, lung, brain, breast, kidney, bladder, urethra, ureter, gall bladder, uterus, ovary, oviduct, prostate, large intestine, small intestine, esophagus, oral cavity, nasal cavity, otic cavity, tumor, neoplastic tissue, or muscle tissue.

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IPC 상세정보(version : 201201)

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