최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0209279 (2008-09-12) |
등록번호 | US-8790257 (2014-07-29) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 76 인용 특허 : 370 |
Systems and methods of detecting an impending cardiac decompensation of a patient measure at least two of an electrocardiogram signal of the patient, a hydration signal of the patient, a respiration signal of the patient or an activity signal of the patient. The at least two of the electrocardiogram
Systems and methods of detecting an impending cardiac decompensation of a patient measure at least two of an electrocardiogram signal of the patient, a hydration signal of the patient, a respiration signal of the patient or an activity signal of the patient. The at least two of the electrocardiogram signal, the hydration signal, the respiration signal or the activity signal are combined with an algorithm to detect the impending cardiac decompensation.
1. A system to detect impending acute cardiac decompensation of a patient, the patient having a skin and an extracellular fluid, the system comprising: impedance circuitry to measure, a hydration signal of the patient and a respiration signal of the patient, wherein the hydration signal corresponds
1. A system to detect impending acute cardiac decompensation of a patient, the patient having a skin and an extracellular fluid, the system comprising: impedance circuitry to measure, a hydration signal of the patient and a respiration signal of the patient, wherein the hydration signal corresponds to a tissue hydration of the patient; anda processor system comprising a computer readable memory in communication with the impedance circuitry, wherein the computer readable memory of the processor system embodies instructions to combine the hydration signal and the respiration signal to detect the impending acute cardiac decompensation. 2. The system of claim 1 wherein the processor system comprises at least one processor at a location remote from the patient configured to detect impending acute cardiac decompensation. 3. The system of claim 1 wherein the processor system, supported with the patient, receives instructions transmitted from a remote site and combines the hydration signal and the respiration signal in response to the instructions to detect the impending acute cardiac decompensation. 4. The system of claim 1, further comprising circuitry to measure an electrocardiogram signal of the patient, wherein the computer readable memory of the processor system embodies instructions to combine the electrocardiogram signal, the hydration signal, and the respiration signal to detect the impending acute cardiac decompensation. 5. The system of claim 4, further comprising circuitry to measure an activity signal of the patient, wherein the computer readable memory of the processor system embodies instructions to combine the electrocardiogram signal, the hydration signal, the respiration signal and the activity signal to detect the impending acute cardiac decompensation. 6. The system of claim 1 wherein the processor system simultaneously uses the hydration signal and the respiration signal to detect the impending acute cardiac decompensation. 7. The system of claim 1 wherein combing comprises the processor system using the hydration signal and the respiration signal to look up a value in a previously existing array. 8. The system of claim 1 wherein combining comprises at least one of adding, subtracting, multiplying, scaling or dividing the hydration signal and the respiration signal. 9. The system of claim 1 wherein the processor system combines the hydration signal and the respiration signal with at least one of a weighted combination, a tiered combination or a logic gated combination, a time weighted combination or a rate of change. 10. The system of claim 1 wherein the processor system determines a flag status in response to the hydration signal and the respiration signal. 11. The system of claim 8 wherein the processor system determines the flag status in response to a change in the hydration signal and the respiration signal. 12. The system of claim 8 wherein the processor system affects the circuitry to make additional signal measurements of the patient in response to the flag status. 13. The system of claim 1 wherein the processor system combines the hydration signal and the respiration signal in response to a time of day. 14. The system of claim 1 wherein the hydration signal and the respiration signal comprise at least one of a derived signal, a time averaged signal, a filtered signal or a raw signal. 15. The system of claim 1, further comprising an accelerometer to measure an activity signal of the patient, wherein the activity signal is combined with the hydration signal and the respiration signal. 16. The system of claim 1, further comprising circuitry to measure an activity signal of the patient, wherein the activity signal comprises an accelerometer signal to determine a posture of the patient. 17. The system of claim 16 wherein the accelerometer signal comprises a three dimensional inclination signal to determine a three dimensional orientation of the patient. 18. The system of claim 1 wherein the processor transmits the hydration signal and the respiration signal to a remote site where the hydration signal and the respiration signal are combined to detect the impending acute cardiac decompensation. 19. The system of claim 1 wherein the processor system comprises a remote processor located at a site remote from the patient and a processor coupled to a support configured to adhere to the skin of the patient and wherein the remote processor is configured to transmit instructions from the site remote from the patient to the processor coupled to the support, and wherein the processor coupled to the support is configured to combine the hydration signal and the respiration signal in response to the instructions to detect the impending acute cardiac decompensation. 20. The system of claim 1 wherein the circuitry comprises circuitry to measure a skin temperature signal of the patient and wherein the computer readable memory of the processor system embodies instructions to correct the hydration signal such that the hydration signal remains substantially unchanged when the measured impedance decreases and the skin temperature increases. 21. The system of claim 1 wherein the patient exhibits heart failure corresponding to a New York Heart Association classification of class III and wherein the computer readable memory embodies instructions to detect the impending acute cardiac decompensation with a sensitivity of at least about 50% and a false positive patient status signal rate of no more than about 1.1 false positive patient status signals per patient year. 22. The system of claim 1 wherein the hydration signal of the patient and the respiration signal of the patient are based on impedance measurements made at a single frequency within a range from about 0.5 kHz to about 20 kHz to determine a tissue impedance. 23. The system of claim 1 wherein the hydration signal of the patient and the respiration signal of the patient are based on impedance measurements made at a single frequency within a range from about 0.5 kHz to about 10 kHz to determine a tissue impedance. 24. The system of claim 1 wherein the computer readable memory embodies instructions to determine the change of the hydration signal based on a baseline hydration value of the patient measured at least one week before the hydration signal and instructions to determine the change of the respiration signal based on a baseline respirations value of the patient measured at least one week before the respiration signal. 25. The system of claim 1 wherein the computer readable memory embodies instructions to determine the change of the hydration signal based on a baseline hydration value of the patient measured with a first adherent device at least one week before the hydration signal measured with a second adherent device and instructions to determine the change of the respiration signal based on a baseline respiration value of the patient measured with the first adherent device at least one week before the respiration signal measured with the second adherent device. 26. A system to predict an impending acute cardiac decompensation of a patient having heart failure, the patient having a skin and extracellular fluid, the system comprising: circuitry to measure an activity signal of the patient, a hydration signal of the patient and a respiration signal of the patient, the circuitry comprising an accelerometer to measure the activity signal of the patient, the circuitry comprising impedance circuitry to measure the hydration signal of the patient and the respiration signal of the patient based on impedance measurements, the impedance measurements having a single frequency within a range from about 1 kHz to about 10 kHz such that the hydration signal corresponds to a tissue hydration of the patient; anda processor system comprising a computer readable memory in communication with the circuitry, wherein the computer readable memory of the processor system embodies instructions to combine the hydration signal and the respirations signal to predict the impending acute cardiac decompensation, wherein the computer readable memory embodies instructions to determine a baseline hydration value of the patient and compare the baseline hydration value to the hydration signal to determine a change of the hydration signal from the baseline hydration value over a 90 day period and instructions to determine a baseline respiration value of the patient and compare the baseline respiration value to the respiration signal over the 90 day period to determine a change of the respiration signal from the baseline respiration value and wherein the processor system embodies instructions to predict the impending acute cardiac decopmensation based on the change of the hydration signal and the change of the respiration signal. 27. The system of claim 1, wherein the computer readable memory embodies instructions to determine a baseline hydration value of the patient and compare the baseline hydration value to the hydration signal to determine a change of the hydration signal from the baseline hydration value and instructions to detect the impending acute cardiac decompensation based in part on the change of the hydration signal. 28. A system to detect impending acute cardiac decompensation of a patient, the system comprising: impedance circuitry to measure a hydration signal of the patient such that the hydration signal corresponds to a tissue hydration of the patient, wherein a respiration signal of the patient is derived from the impedance circuitry; anda processor system in communication with the impedance circuitry, the processor system comprising a computer readable memory storing instructions to detect the impending acute cardiac decompensation based at least in part on the hydration signal of the patient and the respiration signal of the patient. 29. The system of claim 28, wherein the computer readable memory stores instructions to determine a baseline hydration value of the patient and compare the baseline hydration value to the hydration signal to determine a change of the hydration signal from the baseline hydration value and instructions to detect the impending acute cardiac decompensation based at least in part on the change of the hydration signal. 30. The system of claim 29, wherein the hydration signal is based on impedance measurements having a frequency within a range from about 0.5 kHz to about 20 kHz. 31. The system of claim 28, wherein the computer readable memory stores instructions to determine a baseline respiration value of the patient and compare the baseline respiration value to the respiration signal to determine a change of the respiration signal from the baseline respiration value and instructions to detect the impending acute cardiac decompensation based in part on the change of the respiration signal.
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