Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functiona
Biocompatible macromer compositions are provided including an isocyanate-functional polyalkylene oxide combined with at least one multi-functional isocyanate as a first component, and a multi-amino functional compound possessing multiple primary amines as a second component. The isocyanate-functional polyalkylene oxide has pendant polyalkylene oxide groups. The resulting biocompatible macromer composition can be employed as an adhesive or sealant for medical/surgical uses.
대표청구항▼
1. A biocompatible surgical adhesive comprising: an isocyanate-functional methoxy polyethylene glycol combined with at least one multi-functional isocyanate; andat least one diamine,wherein the isocyanate-functional methoxy polyethylene glycol includes degradable linkages and has pendant polyalkylen
1. A biocompatible surgical adhesive comprising: an isocyanate-functional methoxy polyethylene glycol combined with at least one multi-functional isocyanate; andat least one diamine,wherein the isocyanate-functional methoxy polyethylene glycol includes degradable linkages and has pendant polyalkylene oxide groups, andwherein the biocompatible surgical adhesive further comprises an enzyme which increases the degradation rate of the degradable linkages. 2. The biocompatible surgical adhesive as in claim 1, wherein the at least one multi-functional isocyanate is selected from the group consisting of diisocyanates, triisocyanates and combinations thereof. 3. The biocompatible surgical adhesive as in claim 1, wherein the at least one multi-functional isocyanate is a diisocyanate selected from the group consisting of toluene diisocyanate, xylylene diisocyanate, bisphenylene diisocyanate, 4,4′-oxybis(phenyl isocyanate), lysine diisocyanate, 2,4,6-trimethyl-1,3-phenylene diisocyanate, naphthylene diisocyanate, diphenylmethane diisocyanate, trimethylene diisocyanate, tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, ethylethylene diisocyanate, trimethylhexane diisocyanate, heptanemethylene diisocyanate, butane diisocyanate, and combinations thereof. 4. The biocompatible surgical adhesive as in claim 1, wherein the at least one multi-functional isocyanate is a triisocyanate selected from the group consisting of triphenylmethane triisocyanate, tris(isocyanatophenyl) thiophosphate, lysine ester triisocyanate, 1,6,11-undecane triisocyanate, 1,3,6-hexamethylene triisocyanate, 1,8-diisocyanato-4-isocyanatomethyloctane, bicycloheptane triisocyanate, and combinations thereof. 5. The biocompatible surgical adhesive as in claim 1, wherein the diamine is selected from the group consisting of ethylene diamine, hexamethylene diamine, N,N′-bis(3-aminopropyl)-1,2-ethane diamine, N-(3-aminopropyl)-1,3-propane diamine, N-(2-aminoethyl)-1,3 propane diamine, N-(3-aminopropyl)-1,4-butane diamine, N,N′-bis(3-aminopropyl)-1,4-butane diamine, cyclohexane diamine, isomers of cyclohexane diamine, toluene diamine, phenylene diamine, and isophorone diamine. 6. The biocompatible surgical adhesive as in claim 1, wherein the isocyanate-functional methoxy polyethylene glycol combined with the at least one multi-functional isocyanate are present in an amount from about 50% to about 99% by weight of the biocompatible surgical adhesive, and the diamine is present in an amount from about 1% to about 50% by weight of the biocompatible surgical adhesive. 7. The biocompatible surgical adhesive as in claim 1, wherein the isocyanate-functional methoxy polyethylene glycol combined with the at least one multi-functional isocyanate are present in an amount from about 5% to about 45% by weight of the biocompatible surgical adhesive, and the diamine is present in an amount from about 55% to about 95% by weight of the biocompatible surgical adhesive. 8. The biocompatible surgical adhesive as in claim 1, wherein the biocompatible surgical adhesive includes a biologically active agent. 9. The biocompatible surgical adhesive as in claim 1, wherein the biocompatible surgical adhesive includes a medicinal agent. 10. A method for closing a wound comprising: applying the biocompatible surgical adhesive of claim 1 to said wound; andallowing the biocompatible surgical adhesive to set thereby closing said wound. 11. The method of claim 10, wherein the wound is a surgical incision. 12. A method for filling a void in animal tissue comprising: applying the biocompatible surgical adhesive of claim 1 to said void; andallowing the biocompatible surgical adhesive to set thereby filling said void. 13. A method for adhering a medical device to a surface of animal tissue comprising the steps of: applying the biocompatible surgical adhesive of claim 1 to said device, said surface or both;bringing the device, biocompatible surgical adhesive and surface into contact with each other; andallowing the biocompatible surgical adhesive to set thereby adhering the device and surface to each other. 14. The method of claim 13 wherein said medical device is an implant.
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