[특허]Treating inflammation with a binding system

LiveLeaf, Inc.

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특허 상세정보

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내보내기 페이스북 공유 트위터 공유 카카오톡 공유

Treating inflammation with a binding system

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/44
미국특허분류(USC)	424/094.4;
출원번호	US-0203517 (2014-03-10)
등록번호	US-8790640 (2014-07-29)
발명자 / 주소	Huang, Alexander L Wu, Gin
출원인 / 주소	LiveLeaf, Inc.
대리인 / 주소	Boyer, Brian S.
인용정보	피인용 횟수 : 10 인용 특허 : 49

초록

The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.

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1. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising: an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis, pomegranate, resveratrol, and combinations thereof; and,hydrogen peroxide;wherein,the hydrogen peroxide is combined with the extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,the extract comprises a flavanol;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 2. The method of claim 1, wherein the administering of the binding system includes obtaining the binding system as a pharmaceutical formulation comprising the binding system of claim 1 and a pharmaceutically acceptable excipient. 3. The method of claim 1, wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof. 4. The method of claim 1, wherein the binding system comprises a catechin. 5. The method of claim 1, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 6. The method of claim 1, wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50. 7. The method of claim 1, wherein the administering further comprises obtaining a kit for generating the binding system of claim 1, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 8. The method of claim 1, wherein the administering further comprises obtaining a kit comprising the binding system of claim 1, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 9. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of Chinese gall; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a flavanol;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 10. The method of claim 9, wherein the binding system comprises a catechin. 11. The method of claim 9, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 12. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of pomegranate; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a flavanol;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 13. The method of claim 12, wherein the binding system comprising a catechin. 14. The method of claim 12, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 15. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of Camilla Sinensis; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a flavanol;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 16. The method of claim 15, wherein the binding system comprises a catechin. 17. The method of claim 15, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 18. The method of claim 15, wherein the binding system comprises an extract of pomegranate. 19. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising: an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis, pomegranate, resveratrol, and combinations thereof; and,hydrogen peroxide;wherein,the hydrogen peroxide is combined with the an extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,the extract comprises a catechin;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 20. The method of claim 19, wherein the administering of the binding system includes obtaining the binding system as a pharmaceutical formulation the binding system of claim 19 and a pharmaceutically acceptable excipient. 21. The method of claim 19, wherein the binding system comprises a hydrolysable tannin, a condensed tannin, or a combination thereof. 22. The method of claim 19, wherein the binding system comprises a flavanol. 23. The method of claim 19, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 24. The method of claim 19, wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50. 25. The method of claim 19, wherein the administering further comprises obtaining a kit for generating the binding system of claim 19, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 26. The method of claim 19, wherein the administering further comprise obtaining a kit comprising the binding system of claim 19, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 27. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising: an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis, pomegranate, resveratrol, and combinations thereof; and,hydrogen peroxide;wherein,the hydrogen peroxide is combined with the an extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,the extract comprises a gallic acid, epigallic acid, or a combination thereof;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 28. The method of claim 27, wherein the administering of the binding system includes obtaining the binding system as a pharmaceutical formulation comprising the system of claim 27 and a pharmaceutically acceptable excipient. 29. The method of claim 27, wherein the binding system comprises a hydrolysable tannin, a condensed tannin, or a combination thereof. 30. The method of claim 27, wherein the binding system comprises a flavanol. 31. The method of claim 27, wherein the binding system comprises a catechin. 32. The method of claim 27, wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50. 33. The method of claim 27, wherein the administering further comprises obtaining a kit for generating the binding system of claim 27, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 34. The method of claim 27, wherein the administering further comprises obtaining a kit comprising the binding system of claim 27, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 35. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of Chinese gall; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a catechinwherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 36. The method of claim 35, wherein the binding system comprises a flavanol. 37. The method of claim 35, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 38. The method of claim 35, wherein the administering further comprises obtaining a kit for generating the binding system of claim 35, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 39. The method of claim 35, wherein the administering further comprises obtaining a kit comprising the binding system of claim 35, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 40. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of Chinese gall; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a gallic acid, epigallic acid, or a combination thereofwherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the tissue. 41. The method of claim 40, wherein the binding system comprises a flavanol. 42. The method of claim 40, wherein the binding system comprises a catechin. 43. The method of claim 40, wherein the administering further comprises obtaining a kit for generating the binding system of claim 40, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 44. The method of claim 40, wherein the administering further comprises obtaining a kit comprising the binding system of claim 40, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 45. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of pomegranate; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a catechin;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 46. The method of claim 45, wherein the binding system comprises a flavanol. 47. The method of claim 45, wherein the binding system comprises gallic acid, epigallic acid, or a combination thereof. 48. The method of claim 45, wherein the administering further comprises obtaining a kit for generating the binding system of claim 45, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 49. The method of claim 45, wherein the administering further comprises obtaining a kit comprising the binding system of claim 45, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 50. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of pomegranate; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a gallic acid, epigallic acid, or a combination thereofwherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 51. The method of claim 50, the binding system comprising a flavanol. 52. The method of claim 50, the binding system comprising a catechin. 53. The method of claim 50, wherein the administering further comprises obtaining a kit for generating the binding system of claim 50, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 54. The method of claim 50, wherein the administering further comprises obtaining a kit comprising the binding system of claim 50, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 55. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of Camilla Sinensis; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a catechinwherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 56. The method of claim 55, the binding system comprising a flavanol. 57. The method of claim 55, the binding system comprising gallic acid, epigallic acid, or a combination thereof. 58. The method of claim 55, wherein the administering further comprises obtaining a kit for generating the binding system of claim 55, wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites. 59. The method of claim 55, wherein the administering further comprises obtaining a kit comprising the binding system of claim 55, wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites. 60. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising an extract of Camilla Sinensis; and,hydrogen peroxide;wherein the extract and the peroxide are combined to form a binding system; and,the system comprises a gallic acid, epigallic acid, or a combination thereofwherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 61. The method of claim 60, wherein the binding system comprises a flavanol. 62. The method of claim 60, wherein the binding system comprises a catechin. 63. The method of claim 60, wherein the binding system comprises an extract of pomegranate. 64. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising a flavanol; and,hydrogen peroxide;wherein the flavanol and the peroxide are combined to form a binding system;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the subject. 65. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising a catechin; and,hydrogen peroxide;wherein the catechin and the peroxide are combined to form a binding system;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the tissue. 66. A method of treating an inflammation in a subject, comprising: administering an effective amount of a binding system to a subject having an inflammation, the binding system comprising a gallic acid, epigallic acid, or a combination thereof; and,hydrogen peroxide;wherein the gallic acid, epigallic acid, or a combination thereof and the peroxide are combined to form a binding system;wherein the administering inhibits, or ameliorates the symptoms of, the inflammation of the tissue.

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