Generation of antimicrobial surfaces using dendrimer biocides
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-025/00
C07F-007/04
출원번호
US-0357257
(2006-02-17)
등록번호
US-8790672
(2014-07-29)
발명자
/ 주소
Lamba-Kohli, Nina M.
출원인 / 주소
Lamba-Kohli, Nina M.
대리인 / 주소
Ober, Kaler, Grimes & Shriver
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
A silane-QAC-dendritic polymer biocide surface treatment for bath, screen or spray-on application. The silane-QAC-dendritic polymer biocide generally comprises a hyperbranched polymer modified to include functionalized quaternary ammonium for biocidal activity, and further modified to include a func
A silane-QAC-dendritic polymer biocide surface treatment for bath, screen or spray-on application. The silane-QAC-dendritic polymer biocide generally comprises a hyperbranched polymer modified to include functionalized quaternary ammonium for biocidal activity, and further modified to include a functionalized silane moiety to covalently attach the polymer biocide to a variety of substrates through hydrolysis. The hyperbranched polymer may be any one from among a group consisting of dendrimers, dendritic polymers, and hyperbranched polymers, and the functionalized silane moiety may be Siloxane (—Si(OR)3). The resulting surface treatment combines the demonstrated high potency of quaternary ammonium compound dendrimers and hyperbranched polymers with the well-established coupling chemistry of silane functional groups. Upon hydrolysis, the silane groups will covalently attach to functional groups such as amines and hydroxyl groups. This provides an effective biocidal surface treatment for any substrates having exposed hydroxyl, amine or other suitable reactive groups.
대표청구항▼
1. A silane-QAC-hyperbranched polymer biocide, comprising a plurality of polyester based hyperbranched dendritic molecules each characterized by a first plurality of chain ends modified by halogenation to produce chlorinated chain ends defined by terminal hydroxyl groups, followed by quaternization
1. A silane-QAC-hyperbranched polymer biocide, comprising a plurality of polyester based hyperbranched dendritic molecules each characterized by a first plurality of chain ends modified by halogenation to produce chlorinated chain ends defined by terminal hydroxyl groups, followed by quaternization with a tertiary amine to include functionalized quaternary ammonium molecules linked as end groups for biocidal activity, and a second plurality of chain ends modified to include a functionalized silane moiety linked as end groups to covalently attach the polymer biocide to a variety of substrates through hydrolysis. 2. The silane-QAC-hyperbranched polymer biocide according to claim 1, wherein said functionalized silane moiety is Siloxane (—Si(OR)3). 3. A biocidal surface treatment for application to a substrate, comprising: a quaternary ammonium compound;a hydrolysable silane moiety; anda derivatized polyester-based dendritic polymer comprising a plurality of dendritic chains modified by halogenation to produce chlorinated chain ends defined by terminal hydroxyl groups, molecules of said quaternary ammonium compound being linked as end groups to a first plurality of the chain ends of said dendritic polymer, leaving terminal hydroxyl groups at a second plurality of chain ends unreacted, and molecules of said hydrolysable silane moiety being linked as end groups to said second plurality of unreacted chain ends of said dendritic polymer;wherein said quaternary ammonium compound provides biocidal activity and said silane moiety allows covalent attachment of the quaternary ammonium compound to a variety of substrates through hydrolysis. 4. The biocidal surface treatment according to claim 3, wherein said silane moiety prevents leaching of said quaternary ammonium compound. 5. The biocidal surface treatment according to claim 3, wherein said hydrolysable silane moiety will couple to any substrate having exposed hydroxyl and/or amine groups and/or carbonyl groups. 6. The biocidal surface treatment according to claim 5, wherein said substrate includes functional amines and hydroxyl and carbonyl groups, and whereupon hydrolysis of said hydrolysable silane moiety couples to the functional amines and hydroxyl and carbonyl groups of said substrate and covalently attaches thereto. 7. The biocidal surface treatment according to claim 3, wherein said dendritic polymer comprises immobilized quaternary ammonium compounds at an outer molecular boundary. 8. The biocidal surface treatment according to claim 3, wherein said dendritic polymer comprises a plurality of dendrimers having the following formula: where D is a dendrimer, n is a number of reactive terminal groups, X is an anion, R is a linking group, Y is an alkyl, fluoroalkyl or aryl group, A is an alkyl, fluoroalkyl or aryl group, B is an alkyl, fluoroalkyl or aryl group, and z is an integer less than or equal to n/10. 9. The biocidal surface treatment according to claim 3, wherein said dendritic polymer comprises any hyperbranched polymers from among a group comprising polyamidoamine dendrimers, polylysine based dendrimers, polyethylene oxide based dendrimers, based dendrimers, polypropylene imine dendrimers, polyether dendrimers, fluoralkyl dendrimers, polyglycerol dendrimers, polyamidoamine hyperbranched polymers, polyethylene oxide based hyperbranched polymers, polylysine hyperbranched polymers, polyethylene oxide hyperbranched polymers, polyglycerol based hyperbranched polymers, silicon based hyperbranched polymers, fluoralkyl hyperbranched polymers, hyperbranched polyols, polyether hyperbranched polymers and Hybrane™. 10. A biocidal surface treatment according to claim 3 adapted for application to said substrate by anyone of incubation therewith in a bath, by screen application thereto, or by atomized or aerosol spraying thereon. 11. A biocidal surface treatment according to claim 3 suitable for immobilization to said substrate by sitane coupling, said substrate being anyone from among the group including glass, fabric, flooring, polyester, polyamides, polyalcohols, plastic, ceramic and cotton. 12. A biocidal surface treatment according to claim 3, wherein said substrate comprises an article of manufacture chosen from among a group comprising air filters, water filters, garments, woven and non-woven fabrics, glass screens, ductwork, pipes, storage vessels, computer keyboards, instrument panels, medical devices, carpets, flooring, bedding, touch-screens, medical textiles, medical devices, water tanks, plastics and polymers. 13. A biocidal surface treatment according to claim 3, further comprising a carrier from among a group comprising paint, hand-wash, topical ointment, cosmetic, cleaning product, disinfectant product, and water purification product. 14. A biocidal surface treatment according to claim 3 that is non-reactive and substantially nontoxic to human skin. 15. A biocide comprising a plurality of hyperbranched polymers each characterized by a plurality of dendritic chains leading to chain ends characterized by terminal hydroxyl groups, a first plurality of said chain ends being halogenated to chlorinate the terminal hydroxyl groups, the chlorinated first plurality of chain ends of said hyperbranched polymers being modified to include functionalized quaternary ammonium molecules linked as end groups for biocidal activity, and an unreacted second plurality of chain ends being modified to include a functionalized silane moiety linked as end groups to covalently attach the hyperbranched polymer, said biocide being covalently attached to any one from among a group including a medical device, a filter impregnated with said biocide, a touch screen display comprising an LCD panel coated with said biocide, and an article of fabric comprising a woven or non-woven fabric impregnated with said biocide.
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이 특허에 인용된 특허 (8)
Boli Zhou ; Maria G. Ochomogo ; Elias A. Shaheen ; Jessica Y. Chung, Aerosol antimicrobial compositions.
Adnan Siddiqui ; Alfred K. Schultz, Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes.
Siddiqui Adnan ; Schultz Alfred K., Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes.
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