Devices and methods for the regeneration of bony defects
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61F-002/00
A61F-002/28
C03C-003/097
C03C-003/089
C03C-003/078
출원번호
US-0039627
(2011-03-03)
등록번호
US-8795702
(2014-08-05)
발명자
/ 주소
Greenspan, David C.
Katta, Srinivas
출원인 / 주소
Novabone Products, LLC
대리인 / 주소
Brinks Gilson & Lione
인용정보
피인용 횟수 :
5인용 특허 :
34
초록▼
This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the prod
This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles.
대표청구항▼
1. A bone regenerative implantable composition comprising from about 2% to about 20% by weight of a bioresorbable polymer and from about 10% up to about 98% bioactive glass particles that have been pre-reacted with a buffer, and wherein the surface ionic reactivity of the bioactive glass is reduced
1. A bone regenerative implantable composition comprising from about 2% to about 20% by weight of a bioresorbable polymer and from about 10% up to about 98% bioactive glass particles that have been pre-reacted with a buffer, and wherein the surface ionic reactivity of the bioactive glass is reduced as compared to non-prereacted bioactive glass. 2. The composition of claim 1, wherein the bioactive glass is pretreated with the buffer for about 1 hour to about 24 hours. 3. The composition of claim 2, wherein the buffer is TRIS buffer. 4. The composition of claim 1, wherein the bioresorbable polymer is collagen. 5. The composition of claim 1, wherein said bioresorbable polymer is crosslinked. 6. The composition of claim 1, further comprising an extracellular matrix molecule selected from the group consisting of integrins, fibronectin, vitronectin, osteopontin, bone sialoprotein thrombospondin, and fibrinogen. 7. The composition of claim 6, wherein the composition is freeze dried. 8. The bioresorbable polymer of claim 7, wherein said composition is crosslinked. 9. The composition of claim 1, wherein the composition further comprises a homo or copolymer of glycolides, acrylates, lactic acids, and caprolactone. 10. The composition of claim 1, wherein the pores of the bioactive glass range from an average pore size of 100 to 700 microns±50 microns. 11. A method for repairing or regenerating bony defects comprising implanting in a subject in need thereof a bone regenerable composition comprising from about 2% to about 20% by weight of a bioresorbable polymer and from about 10% up to about 98% bioactive glass particles that have been pre-reacted with a buffer, and wherein the surface ionic reactivity of the bioactive glass is reduced as compared to non-prereacted bioactive glass. 12. The method of claim 11, wherein the bioactive glass is pretreated with the buffer for about 1 hour to 24 hours. 13. The method of claim 12, wherein the buffer is TRIS buffer. 14. The method of claim 11, wherein the bioresorbable polymer is collagen. 15. The method of claim 11, wherein the composition is freeze dried. 16. The method of claim 11, wherein the bioresorbable polymer is crosslinked. 17. The method of claim 15, wherein the composition further comprises an extracellular matrix molecule selected from the group consisting of integrins, fibronectin, vitronectin, osteopontin, bone sialoprotein thrombospondin, and fibrinogen. 18. The method of claim 11, wherein the composition further comprises a homo or copolymer of glycolides, acrylates, lactic acids, and caprolactone. 19. The method of claim 11, wherein the pores of the bioactive glass range from an average pore size of 100 to 700 microns±50 microns.
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