Antimicrobial coatings with preferred microstructure for medical devices
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61F-002/00
A01N-025/00
A01N-059/16
A61L-033/00
출원번호
US-0607556
(2009-10-28)
등록번호
US-8808724
(2014-08-19)
발명자
/ 주소
Cichocki, Frank
Hamilton, Michael (Jake)
Ming, Xintian
출원인 / 주소
Ethicon, Inc.
대리인 / 주소
Skula, E. Richard
인용정보
피인용 횟수 :
1인용 특허 :
5
초록▼
A medical device having an antimicrobial coating. The device has a first coating layer having an antimicrobial agent over at least part of the outer surfaces of the device. The first coating has an outer surface. There is a second discontinuous polymeric coating containing an antimicrobial agent, wh
A medical device having an antimicrobial coating. The device has a first coating layer having an antimicrobial agent over at least part of the outer surfaces of the device. The first coating has an outer surface. There is a second discontinuous polymeric coating containing an antimicrobial agent, which is on top of and covering part of the outer surface of the first coating. The second discontinuous coating has a microstructure.
대표청구항▼
1. A medical device, comprising: a non-absorbable structure having a surface; and a coating consisting of a first long lasting, short-ranging antimicrobial coating and a second fast acting, long-ranging discontinuous polymeric antimicrobial coating whereinthe first long lasting, short-ranging antimi
1. A medical device, comprising: a non-absorbable structure having a surface; and a coating consisting of a first long lasting, short-ranging antimicrobial coating and a second fast acting, long-ranging discontinuous polymeric antimicrobial coating whereinthe first long lasting, short-ranging antimicrobial coating is on at least part of the surface, said first antimicrobial coating having a coating surface and comprising a first long-lasting and short-ranging antimicrobial agent; and,the second fast acting, long-ranging discontinuous polymeric antimicrobial coating comprising a second antimicrobial agent, wherein said second antimicrobial coating is applied over at least part of the coating surface of the first antimicrobial coating such that it has a microstructure, and wherein the microstructure of the second discontinuous coating comprises discrete sections, each section having a substantially geometric shape, wherein the second coating comprises a bioabsorbable polymer, and wherein the microstructure of the second coating is substantially equivalent to the length of a bacteria. 2. The medical device of claim 1, wherein the second polymeric discontinuous coating comprises a microstructure that does not prevent bacteria or other microbes from coming in direct contact with the first antimicrobial coating over at least part of the length of the bacteria or microbes. 3. The medical device of claim 1, wherein said first antimicrobial coating layer provides a long lasting inhibition against bacteria attachment for a duration in excess of 14 days post implantation. 4. The medical device of claim 1, wherein the antimicrobial agent in the second discontinuous polymeric coating layer is quickly released from its polymer coating in vivo providing a fast acting and long ranging antimicrobial effect or zone of inhibition against bacteria. 5. The medical device of claim 1, wherein said device comprises a mesh having filaments and fibers. 6. The medical device of claim 5, wherein the first antimicrobial coating layer provides a continuous coverage of the filaments and fibers. 7. The medical device of claim 1, wherein the second discontinuous antimicrobial coating comprises discrete droplets. 8. The medical device of claim 7, where the surface coverage of the solidified droplets on the surface of the first coating layer ranges from about 1% to 70%. 9. The device of claim 1, wherein the first antimicrobial coating layer comprises an antimicrobial metal. 10. The device of claim 9, wherein the antimicrobial metal comprises silver or a silver alloy. 11. The device of claim 1, wherein the discontinuous polymeric coating comprises a bioabsorbable polymer selected from the group consisting of PLA/PGA and PCL/PGA copolymer. 12. The device of claim 1, wherein the second antimicrobial agent is selected from the group consisting of triclosan, chlorohexadine, LAE, AgI, and octenidine. 13. The device of claim 1, wherein the discrete sections have a substantially geometric shape selected from the group consisting of hemispheres, disks, cubes, cylinders, fibers, pyramids, irregular three-dimensional shapes and combinations thereof. 14. The coating of claim 1, wherein the second discontinuous coating is applied by a coating process selected from the group consisting of spraying, printing, and dipping. 15. The medical device of claim 1, wherein the first coating has a first thickness and the second coating has a second thickness. 16. The medical device of claim 1, wherein the distance between the discrete sections is about 1 micron to about 20 microns. 17. The medical device of claim 7, wherein the droplets have a hemispherical shape. 18. The medical device of claim 17, wherein the droplets have a diameter of about 0.1 microns to about 20 microns. 19. A method of performing a surgical repair procedure, comprising: A. providing the medical device of claim 1;B. affixing said medical device to a tissue defect within a body cavity to effectively repair the tissue defect. 20. A method of manufacturing the medical device of claim 1, comprising: providing a medical device comprising a non-absorbable structure having a surface;applying a first long lasting, short-ranging antimicrobial coating on at least part of the surface, said first antimicrobial coating having a coating surface and comprising a first antimicrobial agent; and, applying a second fast acting, long ranging polymeric coating comprising a second antimicrobial agent, wherein said second coating is applied over at least part of the coating surface of the first antimicrobial coating, such that the second coating has a discontinuous microstructure, and wherein the discontinuous microstructure of the second coating comprises a microstructure having discrete sections, the sections having a substantially geometric shape.
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이 특허에 인용된 특허 (5)
Burrell Robert Edward (Sherwood Park CAX) Morris Larry Roy (Edmonton CAX), Anti-microbial coating for medical devices.
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