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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0793385 (2013-03-11) |
등록번호 | US-8809418 (2014-08-19) |
우선권정보 | IL-160987 (2004-03-21); IL-166017 (2004-12-28) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 11 인용 특허 : 532 |
A bone cement comprising a first component and a second component, wherein contacting the first component and the second component produces a mixture which attains a high viscosity an initial period and the viscosity of the mixture remains relatively stable for a working time of at least 5 minutes a
A bone cement comprising a first component and a second component, wherein contacting the first component and the second component produces a mixture which attains a high viscosity an initial period and the viscosity of the mixture remains relatively stable for a working time of at least 5 minutes after the initial setting period, and the mixture is suitable for in-vivo use.
1. A bone cement comprising; a first powder component containing polymer beads having a first average molecular weight and further containing a high molecular weight population of beads having a second average molecular weight that is higher than the first average molecular weight; anda second liqui
1. A bone cement comprising; a first powder component containing polymer beads having a first average molecular weight and further containing a high molecular weight population of beads having a second average molecular weight that is higher than the first average molecular weight; anda second liquid component containing monomers,wherein, the first average molecular weight, the second average molecular weight, and the percentage of beads having the second average molecular weight are selected so that contacting the first component and the second component produces a mixture having a viscosity profile with three phases defining an initial period a working period, and a hardening period,wherein, during the initial period, the viscosity increases at a rate of change that decreases over time until the mixture attains a viscosity greater than 500 Pascal seconds within 180 seconds from mixing the first and second components,wherein, during, the working period of at least 5 minutes, the viscosity remains between 500 and 2000 Pascal secondswherein, during the hardening period, the viscosity increases at a rate of change that increases over time until the mixture hardens, andwherein the mixture is suitable for in-vivo use. 2. The bone cement of claim 1, wherein the working period is at least 8 minutes long. 3. The bone cement of claim 1, wherein the initial period is less than 3 minutes. 4. The bone cement of claim 1, wherein the initial period does not exceed 1 minute. 5. The hone cement of claim 1, wherein the first component includes PMMA and Barium Sulfate. 6. The bone cement of claim 1, wherein the second component includes MMA and DMPT. 7. The bone cement of claim 1, wherein the first component includes PMMA, Barium Sulfate, and Benzoyl Peroxide, and wherein the second component includes MMA, DMPT, and Hydroquinone. 8. The bone cement of claim 1, wherein the viscosity of greater than 500 Pascal-second results at least partly from a polymerization reaction. 9. A bone cement comprising: a first powder component containing polymer beads having a first average molecular weight and further containing a high molecular weight population of beads having a second average molecular weight that is higher than the first average molecular weight; anda second liquid component containing monomers,wherein, the first average molecular weight, the second average molecular weight, and the percentage of beads having the second average molecular weight are selected so that contacting the first component and the second component produces a mixture having a viscosity profile with three phases defining an initial period, a working period, and a hardening period,wherein, during the initial period, the viscosity increases at a rate of change that decreases over time until the mixture attains a viscosity greater than 200 Pascal seconds within 1 minute from mixing the first and second components,wherein, during the working period of at least 5 minutes, the viscosity of the mixture remains between 200 and 2000 Pascal seconds, wherein the viscosity of said mixture is changing by less than 10% in a period of 2 minutes within said working periodwherein, during the hardening period, the viscosity increases at a rate of change that increases over time until the mixture hardens, andwherein the mixture is suitable for in-vivo use. 10. The bone cement of claim 9, wherein the the first component contains PMMA beads and the second component contains MMA monomers, the high molecular weight population of PMMA beads having an average molecular weight between about 600,000 Dalton and about 1,200,000 Dalton. 11. The bone cement of claim 10, wherein the first component contains about 69.4% w/w PMMA, about 30.1% Barium Sulfate, and about 0.5% Benzoyl Peroxide; and wherein the second component contains about 98.5% v/v MMA, about 1.5% DMPT, and about 20 ppm Hydroquinone. 12. The bone cement of claim 10, wherein the first average molecular weight of the PMMA heads is between about 80,000 Dalton and about 180,000 Dalton. 13. The bone cement of claim 10, wherein the first average molecular weight of the PMMA beads is about 110,000 Dalton. 14. The bone cement of claim 10, wherein at least 80% of the PMMA beads have a size between 10 and 200 microns. 15. The bone cement of claim 1, wherein during the initial period, the mixture has substantially no liquid phase. 16. The bone cement of claim 1, wherein during the initial period, the mixture achieves a viscosity of greater than 900 Pascal seconds. 17. The bone cement of claim 1, wherein the polymer beads comprise acrylic polymer beads. 18. The bone cement of claim 1, wherein viscosity of t he mixture changes by less than 20% over a period of 5 minutes during the working period. 19. The bone cement of claim 9, wherein the working period is at least 8 minutes long.
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