A drug delivery device includes a first portion, formed primarily from elastomeric material, and a closure portion, cooperating with an opening of the first portion so as to complete an inflatable drug reservoir. The closure portion extends into the first portion inwards from the opening, defining a
A drug delivery device includes a first portion, formed primarily from elastomeric material, and a closure portion, cooperating with an opening of the first portion so as to complete an inflatable drug reservoir. The closure portion extends into the first portion inwards from the opening, defining at least one region of overlap between the first portion and the closure portion. The first portion and the closure portion define an outlet flow path for releasing a drug from the drug reservoir, with at least part of the outlet flow path passing between the first portion and the closure portion in the region of overlap. The region of overlap is disposed so as to be acted upon by a pressure within the drug reservoir thereby changing a flow impedance of the outlet flow path to provide an at least partially pressure compensated flow regulating mechanism.
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1. A drug delivery device providing a drug reservoir integrated with an at least partially pressure-compensated flow regulating mechanism, the drug delivery device comprising: (a) a first portion formed primarily from elastomeric material, said first portion at least partially defining an inflatable
1. A drug delivery device providing a drug reservoir integrated with an at least partially pressure-compensated flow regulating mechanism, the drug delivery device comprising: (a) a first portion formed primarily from elastomeric material, said first portion at least partially defining an inflatable drug reservoir, said first portion having an opening and a flexible sleeve extending inwards from said opening; and(b) a closure portion cooperating with said opening of said first portion so as to complete said inflatable drug reservoir, wherein said closure portion is implemented as an insert inserted within said flexible sleeve so as to provide a region of overlap between said first portion and said closure portion, said insert being sized to provide pre-tensioning of said inflatable drug reservoir around said insert, and wherein said first portion and said closure portion define an outlet flow path for releasing a drug from said drug reservoir, at least part of said outlet flow path passing between said first portion and said closure portion in said region of overlap, said region of overlap being disposed so as to be acted upon by a pressure within said drug reservoir so as to change a flow impedance of said outlet flow path when the pressure within the reservoir varies, thereby providing an at least partially pressure compensated flow regulating mechanism. 2. The drug delivery device of claim 1, wherein at least one of said first portion and said closure portion is provided with features for defining a multi-channel flow path layer. 3. The drug delivery device of claim 2, wherein said features include a textured surface. 4. The drug delivery device of claim 2, wherein said features include a porous layer. 5. The drug delivery device of claim 1, wherein one of said first portion and said closure portion is provided with an elongated channel deployed to define at least part of said flow path through said region of overlap. 6. A drug delivery device providing a drug reservoir integrated with an at least partially pressure-compensated flow regulating mechanism, the drug delivery device comprising: (a) a first portion formed primarily from elastomeric material, said first portion at least partially defining an inflatable drug reservoir, said first portion having an opening; and(b) a closure portion cooperating with said opening of said first portion so as to complete said inflatable drug reservoir, wherein said closure portion extends into said first portion inwards from said opening to define at least one region of overlap between said first portion and said closure portion, and wherein said first portion and said closure portion define an outlet flow path for releasing a drug from said drug reservoir, at least part of said outlet flow path passing between said first portion and said closure portion in said region of overlap, said region of overlap being disposed so as to be acted upon by a pressure within said drug reservoir so as to change a flow impedance of said outlet flow path when the pressure within the reservoir varies, thereby providing an at least partially pressure compensated flow regulating mechanism, the drug delivery device further comprising a thread extending through said region of overlap such that clearance spaces around or within said thread define at least part of said flow path through said region of overlap. 7. The drug delivery device of claim 1, wherein said insert is formed primarily from a porous material. 8. The drug delivery device of claim 7, wherein said insert and said flexible sleeve are configured such that an extent of contact between said flexible sleeve and said insert varies as a function of the pressure within said inflatable drug reservoir. 9. The drug delivery device of claim 1, wherein said insert is formed with an elongated circumferential channel. 10. The drug delivery device of claim 1, wherein said insert is formed primarily from a bioresorbable material. 11. The drug delivery device of claim 1, wherein at least said first portion is formed from silicone. 12. The drug delivery device of claim 1, wherein at least one of said first portion and said closure portion is formed from a bioresorbable material. 13. The drug delivery device of claim 1, wherein said first portion and said closure portion are formed as two separate components. 14. The drug delivery device of claim 1, wherein said first portion and said closure portion are integrally formed, and wherein the drug delivery device is assembled by inverting at least said flexible sleeve so as to generate said region of overlap. 15. The drug delivery device of claim 1, wherein said insert is implemented as a central core deployed within said inflatable drug reservoir. 16. The drug delivery device of claim 1, further comprising a septum integrated with said first portion for piercing by a needle during filling of said inflatable drug reservoir, wherein said septum projects into said inflatable drug reservoir. 17. The drug delivery device of claim 6, wherein said thread is interposed between a surface of said first portion and a surface of said closure portion in said region of overlap. 18. The drug delivery device of claim 6, wherein said thread is a monofilament thread.
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이 특허에 인용된 특허 (2)
Tsukada Osamu (Nagano JPX), Infuser with balloon for continuously infusing liquid drug.
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