Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/02
A61K-008/18
A61Q-011/00
A01N-039/00
A61K-033/40
A61K-006/00
출원번호
US-0754331
(2010-04-05)
등록번호
US-8821901
(2014-09-02)
발명자
/ 주소
Feldstein, Mikhail M.
Bairamov, Danir F.
Platé, Nicolai A.
Kulichikhin, Valery G.
Chalykh, Anatoly E.
Cleary, Gary W.
Singh, Parminder
출원인 / 주소
A.V. Topchiev Institute of Petrochemical Synthesis Russian Academy of Sciences
대리인 / 주소
Evans, Susan T.
인용정보
피인용 횟수 :
8인용 특허 :
245
초록▼
A method of selecting components for use in water-absorbing pressure-sensitive adhesive compositions is provided. The method involves selecting a film-forming polymer, a ladder-like non-covalent crosslinker that is capable of forming a ladder-like interpolymer complex with the film-forming polymer s
A method of selecting components for use in water-absorbing pressure-sensitive adhesive compositions is provided. The method involves selecting a film-forming polymer, a ladder-like non-covalent crosslinker that is capable of forming a ladder-like interpolymer complex with the film-forming polymer selected, and selecting a carcass-like non-covalent crosslinker that is capable of forming a carcass-like complex with at least one of the film-forming polymer selected or the ladder-like non-covalent crosslinker selected. The adhesive hydrogels provide high adhesion in a swollen state and bridge the gap between conventional pressure sensitive adhesives and bioadhesives. Methods for preparing and using the resulting compositions are also disclosed.
대표청구항▼
1. A method of preparing a bioadhesive, tooth whitening composition comprising: (i) blending a mixture comprising a (1:1) methyacrylic acid-ethyl acrylate copolymer, polyvinylpyrrolidone, poly(ethylene glycol) having a molecular weight from 200-600, and a tooth whitening agent, to thereby form a ble
1. A method of preparing a bioadhesive, tooth whitening composition comprising: (i) blending a mixture comprising a (1:1) methyacrylic acid-ethyl acrylate copolymer, polyvinylpyrrolidone, poly(ethylene glycol) having a molecular weight from 200-600, and a tooth whitening agent, to thereby form a blended polymer-tooth whitening agent composition, wherein the amount of polyvinylpyrrolidone on a weight basis is greater than the amount of the methyacrylic acid-ethyl acrylate copolymer or the amount of the poly(ethylene)glycol,(ii). melting the blended polymer-tooth whitening agent composition from (i) to form a melted composition, and(iii). extruding the melted composition from (ii) to form an extruded tooth whitening composition,the extruded tooth whitening composition comprising from about 20-95 wt % polyvinylpyrrolidone, from about 0.5-40 wt % of methyacrylic acid-ethyl acrylate copolymer, and from about 0.5-60 wt % poly(ethylene glycol). 2. The method of claim 1 wherein the tooth whitening agent is selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, and combinations thereof. 3. The method of claim 1, wherein in step (iii), the melted composition is extruded onto a suitable substrate or backing member. 4. The method of claim 1, wherein the extruded tooth whitening composition comprises about 30-50 wt % polyvinyl pyrrolidone; about 5-10 wt % (1:1) methyacrylic acid-ethyl acrylate copolymer; and about 15-30 wt % polyethylene glycol. 5. The method of claim 2, wherein the tooth whitening agent is hydrogen peroxide. 6. The method of claim 5, wherein the extruded tooth whitening composition comprises from about 5-25 wt % hydrogen peroxide. 7. The method of claim 1, wherein the melting step is carried out at a temperature from about 90° C. to 170° C. 8. The method of claim 7, wherein the melting step is carried out at a temperature from about 100° C. to 140° C. 9. The method of claim 1, wherein additional components are present in the blended polymer-tooth whitening agent composition of step (i). 10. The method of claim 9, wherein a solvent or water is additionally present in the blended polymer-tooth whitening agent composition of step (i). 11. The method of claim 1, further comprising after the extruding step, pressing the extruded teeth whitening composition against a backing member. 12. The method of claim 1, further comprising after the extruding step, laminating the extruded teeth whitening composition to a backing member. 13. The method of claim 3, wherein the thickness of the resulting extruded teeth whitening composition ranges from about 0.050 to 0.80 millimeters. 14. The method of claim 1, wherein the tooth whitening agent mixed in step (i) is in solid form. 15. The method of claim 1, wherein the tooth whitening agent mixed in step (i) is dissolved in a solvent. 16. The method of claim 3, further comprising adding a release liner to the melted composition that has been extruded onto a suitable substrate or backing member. 17. The method of claim 3, wherein the backing member is erodible. 18. The method of claim 2, wherein the tooth whitening agent is a peroxide. 19. The method of claim 5, wherein the extruded tooth whitening composition comprises about 6 weight percent hydrogen peroxide. 20. The method of claim 1, wherein the extruded bioadhesive tooth whitening composition formed in step (iii) is substantially non-tacky but exhibits adhesion upon contact with a moist surface. 21. In a method of preparing a bioadhesive, tooth whitening composition comprising the steps of: (i) blending a (1:1) methyacrylic acid-ethyl acrylate copolymer, polyvinylpyrrolidone, and poly(ethylene glycol) having a molecular weight from 200-600, wherein the amount of polyvinylpyrrolidone on a weight basis is greater than the amount of the methyacrylic acid-ethyl acrylate copolymer or the amount of the poly(ethylene)glycol,(ii). melting the blended composition from (i) to form a melted composition, and(iii). extruding the melted composition from (ii) to form an, extruded composition,the improvement comprising the inclusion of a tooth whitening agent directly in the blending step to form a blended polymer-tooth whitening agent composition, wherein the extruded tooth whitening composition comprises from about 20-95 wt % polyvinylpyrrolidone, from about 0.5-40 wt % of methyacrylic acid-ethyl acrylate copolymer, and from about 0.5-60 wt % poly(ethylene glycol).
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이 특허에 인용된 특허 (245)
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