Tannin formulation for treating gastrointestinal spasms in a subject having colorectal cancer
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-031/00
A61K-031/075
A01N-039/00
A61K-051/00
A61L-012/12
C07G-001/00
A61K-031/192
A61K-033/40
A61K-031/7028
출원번호
US-0222607
(2014-03-22)
등록번호
US-8822544
(2014-09-02)
발명자
/ 주소
Huang, Alexander L
Wu, Gin
출원인 / 주소
Liveleaf, Inc.
대리인 / 주소
Syndicated Law PC
인용정보
피인용 횟수 :
11인용 특허 :
49
초록▼
Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen exist
Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
대표청구항▼
1. A method of treating a gastrointestinal spasm in a subject having colorectal cancer, the method comprising: administering an effective amount of a formulation to a subject having a gastrointestinal spasm, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceu
1. A method of treating a gastrointestinal spasm in a subject having colorectal cancer, the method comprising: administering an effective amount of a formulation to a subject having a gastrointestinal spasm, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient;wherein,the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and,the formulation relieves a gastrointestinal spasm in the subject having colorectal cancer when compared to a second subject in a control group also having colorectal cancer in which the formulation was not administered. 2. The method of claim 1, wherein the tannin is a hydrolysable tannin. 3. The method of claim 1, wherein the tannin is a water soluble condensed tannin. 4. The method of claim 1, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 5. The method of claim 1, wherein the tannin is a flavanol. 6. The method of claim 1, wherein the tannin is a catechin. 7. The method of claim 1, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 8. The method of claim 1, wherein the weight ratio of the tannin:peroxide ranges from about 1:1 to about 1:50. 9. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 10. A method of treating a gastrointestinal spasm in a subject having colorectal cancer, comprising: administering an effective amount of a formulation to a subject having a gastrointestinal spasm, the formulation produced from a process includingcombining a water soluble tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;removing free hydrogen peroxide from the combination; and,mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation;wherein,the administering includes selecting a desired concentration of the formulation for the administering; and,the formulation relieves a gastrointestinal spasm in the subject having colorectal cancer when compared to a second subject in a control group also having colorectal cancer in which the formulation was not administered. 11. The method of claim 10, wherein the tannin is a hydrolysable tannin. 12. The method of claim 10, wherein the tannin is a water soluble condensed tannin. 13. The method of claim 10, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 14. The method of claim 10, wherein the tannin is a flavanol. 15. The method of claim 10, wherein the tannin is a catechin. 16. The method of claim 10, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 17. The method of claim 10, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 18. The method of claim 10, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 19. The method of claim 1, wherein the tannin is a hydrolysable tannin having from 3-12 galloyl residues. 20. The method of claim 2, wherein the hydrolysable tannin is a product of a water extraction of Chinese gall. 21. The method of claim 3, wherein the water soluble condensed tannin is a product of a water extraction of green tea leaves. 22. The method of claim 1, wherein the tannin is a gallotannin. 23. The method of claim 1, wherein the tannin is an ellagitannin. 24. The method of claim 23, wherein the tannin is a punicalagin. 25. A method of treating a gastrointestinal spasm in a subject having colorectal cancer, comprising: administering an effective amount of a composition to a subject having a gastrointestinal spasm, the composition produced from a process includingcombining a water soluble, hydrolysable tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;wherein,the administering includes selecting a desired concentration of the formulation for the administering; and,the formulation relieves a gastrointestinal spasm in the subject having colorectal cancer when compared to a second subject in a control group also having colorectal cancer in which the formulation was not administered. 26. The method of claim 25, wherein the water soluble tannin is a gallotannin or an ellagitannin, and the mixing further comprises removing free hydrogen peroxide from the combination; and, mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation. 27. The method of claim 25, wherein the tannin is an ellagitannin. 28. The method of claim 27, wherein the tannin is a punicalagin.
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