A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy
A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve, the electrode also configured to apply therapy to the vagus nerve upon application of a therapy cycle to the electrode; an implantable neuroregulator for placement in the body of the patient beneath the skin layer, the implantable neuroregulator being configured to generate a therapy cycle, wherein the therapy cycle comprises an on time during which an electrical signal is delivered, the electrical signal comprising: a) a set of pulses applied at a first selected frequency of about 150-10,000 Hz, wherein each pulse of the set of pulses has a pulse width of at least 0.01 milliseconds and less than the period of the first selected frequency.
대표청구항▼
1. A method of treating a gastrointestinal disorder or a condition associated with excess weight in a subject in need thereof comprising: programming an implantable neuroregulator to apply a therapy cycle to an electrode placed at a vagus nerve, wherein each therapy cycle comprises a) a high frequen
1. A method of treating a gastrointestinal disorder or a condition associated with excess weight in a subject in need thereof comprising: programming an implantable neuroregulator to apply a therapy cycle to an electrode placed at a vagus nerve, wherein each therapy cycle comprises a) a high frequency burst of electrical signal having a first selected frequency of at least 1000 Hz, wherein the high frequency burst of electrical signals comprises one or more pulses that have a pulse width of about 0.01 milliseconds to about 0.09 milliseconds, and a current of about 0.1 to 20 mAmps; b) more than one burst of a second low frequency electrical signal, each burst having a second selected frequency of at least 40 Hz and less than 150 Hz, wherein each of the bursts of low frequency electrical signals comprises one or more pulses that have a pulse width of about 0.05 microseconds to about 0.5 microseconds, a current of about 0.1 to 20 mAmps and a delay period between each burst; wherein the high frequency burst and low frequency burst are delivered during the same therapy cycle and at least partially downregulate activity on the nerve; c) an on period of at least 2 minutes d) an off period, wherein the off period is selected to allow at least partial recovery of nerve activity; and e) a total charge of about 5 to 1000 microcoulombs or less per therapy cycle. 2. The method according to claim 1, wherein the low frequency signal precedes the high frequency signal and follows the high frequency signal. 3. The method according to claim 1, wherein the gastrointestinal disorder or condition is selected from the group consisting of obesity, hypertension, diabetes, and combinations thereof. 4. The method of claim 1, further comprising administering one or more agents that treat the gastrointestinal disorder or condition or affect weight loss. 5. The method of claim 4, wherein the agents that affect weight loss are selected from the group consisting of agents that enhance the sensation of satiety, agents that decrease appetite, agents that block the absorption of fat or other nutrients, agents that inhibit enzymes that digest fat, agents that are thermogenic, and combinations thereof. 6. The method of claim 5, wherein the agent that enhances a sensation of satiety is selected from the group consisting of somatostatin receptor agonists, GLP-1 agonists, GLP-1 variants, peptide PYY, POMC agonists, neuropeptide Y inhibitors, topiramate, tegretol, bupropion, naltrexone, zonisamide, amylin, amylin analogues, oxyntomodulin and combinations thereof. 7. The method of claim 5, wherein the agent that decreases appetite is selected from the group consisting of phentermine, fenfluramine, dexfenfluramine, endocannabinoid receptor antagonists, ghrelin antagonists, orexin antagonists, somatostatin receptor agonist, GLP-1, PYY, cholecystokinin agonists, and combinations thereof. 8. The method of claim 5, wherein the agent that block absorption of fat or other nutrients is selected from the group consisting of orlistat, a lipin inhibitor, and combinations thereof. 9. The method of claim 5, wherein the agent that is thermogenic is selected from the group consisting of sibutramine, leptin, leptin agonists, leptin analogues, CNTF, CNTF analogues, and combinations thereof. 10. The method of claim 1, wherein the first selected frequency is selected from about 1000 to 5000 Hz. 11. The method of claim 1, wherein the one or more set of pulses has about 1-20 pulses. 12. The method of claim 1, wherein the low frequency electrical signal has a current amplitude of about 1 mAmp or less. 13. The method of claim 1, further comprises a treatment period having one or more therapy cycles. 14. The method of claim 13, wherein the treatment period is at least 6 hours.
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Edwards Stuart D. (Los Altos CA) Lax Ronald G. (Grass Valley CA) Lundquist Ingemar H. (Pebble Beach CA) Sharkey Hugh R. (Redwood City CA), Medical probe device and method.
Durand, Dominique; Sahin, Mesut; Haxhiu, Musa A., Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea.
Hill, Michael R. S.; Jahns, Scott E.; Keogh, James R.; Euler, David E.; Ujhelyi, Michael R.; Rakow, Nancy J., Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure.
Boveja,Birinder R.; Widhany,Angely, Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders.
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Pasricha Pankai J. (5007 Southern Star Ter. Columbia MD 21044) Kalloo Anthony N. (10708 Forestgate Pl. Glenndale MD 20769), Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction.
Stuart D. Edwards ; John Gaiser ; David S. Utley, Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors.
Armstrong, Randolph K.; Maschino, Steven E.; Scott, Timothy L., Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device.
Knudson, Mark B.; Wilson, Richard R.; Tweden, Katherine S.; Conrad, Timothy R., Nerve stimulation and blocking for treatment of gastrointestinal disorders.
Douglas Donald D. (2009 Madison Ave. Lewisburg PA 17837), Percutaneously placed electrical gastrointestinal pacemaker stimulatory system, sensing system, and pH monitoring system.
Cigaina Valerio (Via 4 Novembre 3a 31050 Villorba (Treviso) ITX), Process and device for treating obesity and syndromes related to motor disorders of the stomach of a patient.
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Terry ; Jr. Reese S. (Houston TX) Wernicke Joachim F. (League City TX) Baker ; Jr. Ross G. (Houston TX), Therapeutic treatment of migraine symptoms by stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of eating disorders by nerve stimulation.
Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX) Marquette Andre (Stamford CT), Treatment of motility disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Zabara Jacob (Philadelphia PA), Treatment of neuropsychiatric disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of patients in coma by nerve stimulation.
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Leimbach, Richard L.; Shelton, IV, Frederick E.; Morgan, Jerome R.; Schellin, Emily A., End effector detection and firing rate modulation systems for surgical instruments.
Shelton, IV, Frederick E.; Schmid, Katherine J.; Scheib, Charles J.; Aronhalt, Taylor W.; Swayze, Jeffrey S.; Contiliano, Joseph H.; Yang, Chunlin; Henderson, Cortney E.; Aldridge, Jeffrey L., End effector including an implantable arrangement.
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Swayze, Jeffrey S.; Hueil, Joseph C.; Morgan, Jerome R.; Shelton, IV, Frederick E., Stapling assembly configured to produce different formed staple heights.
Beckman, Andrew T.; Nalagatla, Anil K.; Hibner, John A.; Shelton, IV, Frederick E., Surgical apparatus configured to assess whether a performance parameter of the surgical apparatus is within an acceptable performance band.
Beckman, Andrew T.; Nalagatla, Anil K.; Koch, Jr., Robert L.; Hibner, John A.; Shelton, IV, Frederick E., Surgical apparatus configured to track an end-of-life parameter.
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Shelton, IV, Frederick E.; Swayze, Jeffrey S.; Baxter, III, Chester O., Surgical fastening apparatus with a rotary end effector drive shaft for selective engagement with a motorized drive system.
Overmyer, Mark D.; Auld, Michael D.; Adams, Shane R.; Shelton, IV, Frederick E.; Harris, Jason L., Surgical instrument comprising a lockable battery housing.
Kerr, Wendy A.; Lytle, IV, Thomas W.; Overmyer, Mark D.; Swensgard, Brett E.; Sackett, Kevin D.; Leimbach, Richard L.; Houser, Kevin L.; Morgan, Jerome R.; Shelton, IV, Frederick E., Surgical instrument system comprising lockable systems.
Shelton, IV, Frederick E.; Baxter, III, Chester O., Surgical instrument with an anvil that is selectively movable about a discrete non-movable axis relative to a staple cartridge.
Hunter, Morgan R.; Schultz, Darwin L.; Worthington, Sarah A.; Shelton, IV, Frederick E.; Weaner, Lauren S.; Vendely, Michael J., Surgical instrument with articulating and axially translatable end effector.
Hunter, Morgan R.; Schultz, Darwin L.; Dunki-Jacobs, Adam R.; Baxter, III, Chester O.; Swayze, Jeffrey S., Surgical instruments with tensioning arrangements for cable driven articulation systems.
Overmyer, Mark D.; Yates, David C.; Shelton, IV, Frederick E.; Adams, Shane R.; Leimbach, Richard L., Surgical stapler having motor control based on an electrical parameter related to a motor current.
Shelton, IV, Frederick E.; Setser, Michael E.; Weisenburgh, II, William B., Surgical stapling instrument with lockout features to prevent advancement of a firing assembly unless an unfired surgical staple cartridge is operably mounted in an end effector portion of the instrument.
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