Multi-fluidic cartridges for sample analysis and methods for using same
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-035/10
B01L-003/00
출원번호
US-0331136
(2011-12-20)
등록번호
US-8826752
(2014-09-09)
발명자
/ 주소
Miller, Cary James
출원인 / 주소
Abbott Point of Care Inc.
인용정보
피인용 횟수 :
2인용 특허 :
20
초록▼
The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a
The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and (c) at least one pneumatic pump configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit.
대표청구항▼
1. A multi-fluidic cartridge for sample analysis, comprising: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors, wherein said first conduit includes a capillary stop oriented between said sample entry port and said o
1. A multi-fluidic cartridge for sample analysis, comprising: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors, wherein said first conduit includes a capillary stop oriented between said sample entry port and said one or more sensors;(b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and(c) at least one pneumatic pump configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit. 2. The cartridge of claim 1, wherein each of said different fluids is selected from the group consisting of a reagent fluid, a wash fluid, a calibrant fluid, and a diluent. 3. The cartridge of claim 1, wherein at least two of said delivery conduits are in fluid communication with a shared conduit configured for delivering a plurality of fluids from said at least two of said delivery conduits to said first conduit. 4. The cartridge of claim 1, wherein at least two of said delivery conduits are in fluid communication with a shared conduit configured for delivering a plurality of fluids from said at least two of said delivery conduits to said first conduit. 5. The cartridge of claim 4, wherein said shared conduit is in fluid communication with said first conduit at a point downstream of said capillary stop. 6. The cartridge of claim 4, wherein said shared conduit is in fluid communication with said first conduit at a point upstream of said capillary stop. 7. The cartridge of claim 1, wherein at least some of said plurality of fluidic cartridges are oriented longitudinally with respect to one another. 8. The cartridge of claim 1, wherein at least some of said plurality of fluidic cartridges are oriented laterally with respect to one another. 9. The cartridge of claim 1, wherein at least some of said plurality of fluidic cartridges are oriented longitudinally with respect to one another, and wherein at least some of said plurality of fluidic cartridges are oriented laterally with respect to one another. 10. The cartridge of claim 1, wherein said plurality of fluidic pouches includes a first fluidic pouch and a second fluidic pouch, wherein said first fluidic pouch contains a first fluid and a first pneumatic pump controls movement of said first fluid to said first conduit and controls movement of said fluid sample in said first conduit, and wherein said second fluidic pouch contains a second fluid, movement of which is controlled by a second pneumatic pump. 11. The cartridge of claim 10, wherein said first fluid comprises a diluent. 12. The cartridge of claim 1, wherein said first conduit begins at said sample entry port and ends at a waste chamber. 13. A multi-fluidic cartridge for sample analysis, comprising: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors,(b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and(c) at least one pneumatic pump included in said cartridge configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit and that controls movement of said fluid sample and said plurality of different fluids. 14. The cartridge of claim 11, wherein said cartridge includes a plurality of pneumatic pumps, one of which controls movement of said fluid sample, and at least one of which controls movement of said plurality of different fluids. 15. The cartridge of claim 11, wherein said cartridge includes a plurality of pneumatic pumps, and wherein movement of each of said different fluids is controlled by a different pneumatic pump. 16. A process for analyzing a fluid sample with a multi-fluidic cartridge, comprising: (a) introducing said fluid sample into a sample entry port and allowing said fluid sample to enter a first conduit beginning at said sample entry port and in fluid communication with one or more sensors, wherein said first conduit includes a capillary stop oriented between said sample entry port and said one or more sensors, and wherein operation of a pump causes said fluid sample to pass through said capillary stop and to said one or more sensors;(b) rupturing a plurality of fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering said fluid to said first conduit;(c) transporting said different fluids through said delivery conduits and to said first conduit;(d) transporting said fluid sample through said first conduit and over said one or more sensors; and(e) analyzing said fluid sample at said one or more sensors for the presence or concentration of an analyte or a property of said fluid sample. 17. The process of claim 16, further comprising: mixing at least one of said different fluids with said fluid sample in said first conduit. 18. The process of claim 16, wherein at least one of said different fluids is transported to said first conduit before step (d), and at least one of said different fluids is transported to said first conduit after step (d). 19. The process of claim 16, wherein each of said different fluids is selected from the group consisting of a reagent fluid, a wash fluid, a calibrant fluid, and a diluent. 20. The process of claim 16, wherein at least two of said delivery conduits are in fluid communication with a shared conduit, said process further comprising the step of: transporting a plurality of said different fluids from at least two of said delivery conduits through the shared conduit and to said first conduit. 21. The process of claim 16, wherein at least two of said delivery conduits are in fluid communication with a shared conduit configured for delivering a plurality of fluids from said at least two of said delivery conduits to said first conduit. 22. The process of claim 21, wherein said shared conduit is in fluid communication with said first conduit at a point downstream of said capillary stop. 23. The process of claim 21, wherein said shared conduit is in fluid communication with said first conduit at a point upstream of said capillary stop. 24. The process of claim 16, wherein said cartridge includes a single pneumatic pump that controls movement of said fluid sample and said plurality of different fluids. 25. The process of claim 16, wherein said cartridge includes a plurality of pneumatic pumps, one of which controls movement of said fluid sample, and at least one of which controls movement of said plurality of different fluids. 26. The process of claim 16, wherein said cartridge includes a plurality of pneumatic pumps, and wherein movement of each of said different fluids is controlled by a different pneumatic pump. 27. The process of claim 16, wherein said plurality of fluidic pouches includes a first fluidic pouch and a second fluidic pouch, wherein said first fluidic pouch contains a first fluid and a first pneumatic pump controls movement of said first fluid to said first conduit and controls movement of said fluid sample in said first conduit, and wherein said second fluidic pouch contains a second fluid, movement of which is controlled by a second pneumatic pump. 28. The process of claim 27, wherein said first fluid comprises a diluent.
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