Anti-clogging ventricular catheter for cerebrospinal fluid drainage
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/00
A61M-027/00
A61B-005/03
A61M-005/142
출원번호
US-0676404
(2008-09-10)
등록번호
US-8827944
(2014-09-09)
국제출원번호
PCT/US2008/075823
(2008-09-10)
§371/§102 date
20100422
(20100422)
국제공개번호
WO2009/036039
(2009-03-19)
발명자
/ 주소
Sevrain, Lionel C.
출원인 / 주소
Lers Surgical, LLC
대리인 / 주소
Novak Druce Connolly Bove + Quigg LLP
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
A novel ventricular catheter designed to reduce CSF shunt obstruction is disclosed comprising a tip using a membrane without any opening and capable of filtering the CSF. When the CSF flows through the membrane, neither tissue (choroid plexus, blood cells, tumor cells, suctioned ependymal tissue) no
A novel ventricular catheter designed to reduce CSF shunt obstruction is disclosed comprising a tip using a membrane without any opening and capable of filtering the CSF. When the CSF flows through the membrane, neither tissue (choroid plexus, blood cells, tumor cells, suctioned ependymal tissue) nor proteins can break through the membrane, making this ventricular catheter capable of preventing obstruction from tissue invasion but also preventing clogging from protein precipitation, coagulation or flocculation along the downstream shunt system.
대표청구항▼
1. A ventricular catheter comprising: a tube for diverting cerebrospinal fluid, the tube having an extra-cerebral end and an intra-cerebral end;a membrane having an apex and a connecting end opposing the apex, wherein the connecting end is attached to the intra-cerebral end of the tube; anda plurali
1. A ventricular catheter comprising: a tube for diverting cerebrospinal fluid, the tube having an extra-cerebral end and an intra-cerebral end;a membrane having an apex and a connecting end opposing the apex, wherein the connecting end is attached to the intra-cerebral end of the tube; anda plurality of memory ribs extending along a surface of the membrane from the connecting end to the apex,wherein the ventricular catheter has a relaxed configuration in which the memory ribs spontaneously return to a pre-shaped conformation to expand a diameter of the membrane, andwherein the ventricular catheter has a narrowed configuration in which the diameter of the membrane is smaller compared to the relaxed configuration. 2. The ventricular catheter of claim 1, wherein the membrane is semipermeable. 3. The ventricular catheter of claim 1, wherein the tube comprises one selected from the group consisting of latex, silicone, polytetrafluoroethylene (PTFE), and combinations thereof. 4. The ventricular catheter of claim 2, wherein the semi-permeable membrane comprises one selected from the group consisting of polyacrylate, polyvinylidene, polyvinyl chloride copolymer, polyurethane, polystyrene, polyamide, cellulose acetate, cellulose nitrate, polysulfone, polyphosphazene, polyacrylonitrile, poly(acrylonitrile/covinyl chloride), PTFE, and combinations thereof. 5. A kit comprising the ventricular catheter of claim 1, andone selected from the group consisting of an introducer device for implanting the catheter in a subject, a stylet for implanting the catheter in a subject, and combinations thereof,wherein the ventricular catheter is slidably houseable inside the introducer device,wherein a stylet is inserted within the ventricular catheter. 6. The kit of claim 5, wherein the introducer device is cylindrical. 7. The kit of claim 5, wherein the introducer device at least partially encases the catheter. 8. The kit of claim 7, wherein the introducer device comprises one end that is slotted. 9. The kit of claim 5, wherein the kit comprises both the introducer device and the stylet. 10. The kit of claim 5, wherein the introducer device comprises one selected from the group consisting of metal, plastic, and combinations thereof. 11. A method of diverting cerebrospinal fluid from a brain ventricle of a subject via a tube for diverting cerebrospinal fluid, the tube having an extra-cerebral end and an intra-cerebral end; a membrane having an apex and a connecting end opposing the apex, wherein the connecting end is attached to the intra-cerebral end of the tube; anda plurality of memory ribs extending along a surface of the membrane from the connecting end to the apex,wherein the ventricular catheter has a relaxed configuration in which the memory ribs spontaneously return to a pre-shaped conformation to expand a diameter of the membrane, andwherein the ventricular catheter has a narrowed configuration in which the diameter of the membrane is smaller compared to the relaxed configuration,the method comprising:puncturing a brain cortex of the subject with an introducer device;sliding the ventricular catheter, in a folded configuration through the introducer device up to the ventricular cavity, wherein when in the folded configuration the membrane is in a deflated shape;removing the introducer from the brain cortex to expand the membrane to the relaxed configuration within the ventricular cavity; anddiverting cerebrospinal fluid of the subject through the tube. 12. The method of claim 11, wherein the subject is further defined as having hydrocephalus. 13. The method of claim 11, further comprising positioning a stylet within the catheter prior to the puncturing step. 14. The ventricular catheter of claim 1, wherein the membrane is permeable. 15. The ventricular catheter of claim 1, wherein the membrane is a coil-shaped serpentine membrane. 16. The ventricular catheter of claim 15, wherein the memory ribs extend around the membrane in a helix shape. 17. A method of diverting cerebrospinal fluid from a brain ventricle of a subject via a tube for diverting cerebrospinal fluid, the tube having an extra-cerebral end and an intra-cerebral end; a membrane having an apex and a connecting end opposing the apex, wherein the connecting end is attached to the intra-cerebral end of the tube; anda plurality of memory ribs extending along a surface of the membrane from the connecting end to the apex,wherein the ventricular catheter has a relaxed configuration in which the memory ribs spontaneously return to a pre-shaped conformation to expand a diameter of the membrane, andwherein the ventricular catheter has a narrowed configuration in which the diameter of the membrane is smaller compared to the relaxed configuration,the method comprising:inserting a stylet within a lumen of the ventricular catheter, wherein the stylet straightens the tube, spreads out the plurality of memory ribs, and folds the membrane by applying force to an inner part of the ventricular catheter;puncturing a brain cortex of the subject;sliding the ventricular catheter, in the narrowed configuration to a ventricular cavity of the brain ventricle;removing the stylet from the ventricular catheter to expand the membrane to the relaxed configuration within the ventricular cavity; anddiverting cerebrospinal fluid of the subject through the tube.
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이 특허에 인용된 특허 (8)
Magram Gary (402 Faulk Rd. ; Apt. 6B12 Wilmington DE 19803), Cerebrospinal fluid shunt.
Lazarus Harrison (1474 Penrose Dr. Salt Lake City UT 84103) Nelson James A. (1708 Forest Hills Dr. Salt Lake City UT 84106), Peritoneal fluid treatment apparatus, package and method.
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