Embodiments herein comprise a hemostatic composition comprising a plurality of liquid expandable articles capable of expanding upon contact with a liquid. A suitable composition comprises a plurality of liquid-expandable articles that may be mechanically uncoupled from one another and therefore may
Embodiments herein comprise a hemostatic composition comprising a plurality of liquid expandable articles capable of expanding upon contact with a liquid. A suitable composition comprises a plurality of liquid-expandable articles that may be mechanically uncoupled from one another and therefore may be capable of moving independently from one another. The plurality of liquid-expandable articles may comprise a compressed material capable of a high-degree of expansion upon liquid contact.
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1. A hemostatic composition comprising a plurality of liquid-expandable articles, wherein: individual liquid-expandable articles within the plurality of liquid-expandable articles have a volume greater than 5 mm3, comprise compressed non-oxidized cellulose, and store mechanical energy in a compresse
1. A hemostatic composition comprising a plurality of liquid-expandable articles, wherein: individual liquid-expandable articles within the plurality of liquid-expandable articles have a volume greater than 5 mm3, comprise compressed non-oxidized cellulose, and store mechanical energy in a compressed state; andthe individual liquid-expandable articles release the stored mechanical energy and mechanically expand into expanded articles upon contact with a liquid, and wherein a volume of the expanded articles is at least 4 times a volume of the liquid-expandable articles. 2. The hemostatic composition of claim 1, further comprising one or more therapeutic agents. 3. The hemostatic composition of claim 2, wherein the one or more therapeutic agents comprises a hemostatic agent. 4. The hemostatic composition of claim 2, wherein the one or more therapeutic agents comprise chitosan. 5. The hemostatic composition of claim 1, wherein the compressed non-oxidized cellulose is a compressed non-oxidized cellulose sponge. 6. The hemostatic composition of claim 1, wherein each liquid-expandable article within the plurality of liquid-expandable articles comprises a marker. 7. The hemostatic composition of claim 6, wherein the marker is radiopaque. 8. The hemostatic composition of claim 1, wherein the liquid-expandable articles are capable of expanding to 90% or greater of their maximum expansion capacity in 30 seconds or less following immersion in liquid. 9. The hemostatic composition of claim 1, wherein the non-oxidized cellulose comprises a regenerated non-oxidized cellulose sponge. 10. The hemostatic composition of claim 1, wherein the individual liquid-expandable articles have a longitudinal axis corresponding to a longitudinal dimension of the individual expanded articles, the individual liquid-expandable articles have a lateral axis corresponding to a lateral dimension of the individual expanded articles, and mechanical expansion of the individual liquid-expandable articles is principally along the longitudinal axis. 11. The hemostatic composition of claim 1, wherein the individual liquid-expandable articles have a lateral dimension and a longitudinal dimension less than the lateral dimension. 12. The hemostatic composition of claim 1, wherein the individual expanded articles have a cylindrical shape. 13. The hemostatic composition of claim 1, wherein tyle individual liquid-expandable articles have a cylindrical shape. 14. The hemostatic composition of claim 1, wherein the liquid-expandable articles are capable of expanding to 80% or greater of their maximum expansion capacity in 10 seconds or less following immersion in liquid. 15. A device, comprising: an applicator; andthe hemostatic composition according to any one of claims 1 to 3 and 5 to 8. 16. The device of claim 15, wherein: the applicator comprises a receptacle having an output end; andthe hemostatic composition is positioned in the receptacle. 17. The device of claim 16 wherein the receptacle is a tube. 18. The device of claim 17, further comprising a piston positioned in the tube to eject the hemostatic composition from the tube through the output end. 19. The device of claim 16, further comprising a valve coupled to the output end. 20. A method of treating an individual having a bleeding wound, comprising applying to the wound a plurality of liquid-expandable articles wherein: individual liquid-expandable articles have a volume greater than 5 mm3, comprise compressed non-oxidized cellulose, and store mechanical energy in a compressed state; andthe individual liquid-expandable articles release the stored mechanical energy and mechanically expand into elongate expanded articles upon being exposed to blood in the wound to collectively induce hemostasis, and the liquid-expandable articles are capable of mechanically expanding into expanded articles having a volume at least 4 times that of the liquid-expandable articles. 21. The method of claim 20 wherein said plurality of liquid-expandable articles are applied to the wound with an applicator. 22. The method according to claim 20, wherein the wound is defined by a cavity with a volume bounded by a surface through which blood is flowing into the cavity, the cavity having an entry opening that is in communication with the cavity. 23. The method of claim 22, wherein said plurality of liquid-expandable articles expand and conform to a shape defined by at least a portion of the cavity. 24. A method of manufacturing a medical device, comprising: compressing non-oxidized cellulose;cutting the compressed non-oxidized cellulose into a plurality of liquid-expandable articles, wherein the individual liquid-expandable articles store mechanical energy in a dry, compressed state, the individual liquid expandable articles release the stored mechanical energy and mechanically expand into elongate expanded articles upon contact with a liquid, and a volume of the expanded articles is at least 4 times a volume of the liquid-expandable articles; andloading the plurality of liquid expandable articles into an applicator. 25. The method of claim 24, further comprising applying a therapeutic agent to the non-oxidized cellulose prior to, during or subsequent to cutting the non-oxidized cellulose. 26. The method of claim 24, wherein the individual liquid-expandable articles have a longitudinal axis corresponding to a longitudinal dimension of the individual expanded articles, the individual liquid-expandable articles have a lateral axis corresponding to a lateral dimension of the individual expanded articles, and mechanical expansion of the individual liquid-expandable articles is principally along the longitudinal axis. 27. The method of claim 24, wherein the individual liquid-expandable articles have a lateral dimension and a longitudinal dimension less than the lateral dimension. 28. The method of claim 24, wherein the individual expanded articles have a cylindrical shape. 29. The method of claim 24, wherein the individual liquid-expandable articles have a cylindrical shape. 30. The method of claim 24, wherein the liquid-expandable articles are capable of expanding to 80% or greater of their maximum expansion capacity in 10 seconds or less following immersion in liquid. 31. A hemostatic composition comprising a plurality of liquid-expandable articles, wherein: individual liquid-expandable articles within the plurality of liquid-expandable articles have a volume greater than 5 mm3, comprise a compressed non-oxidized cellulose, and store mechanical energy in a compressed state; andthe individual liquid-expandable articles release the stored mechanical energy and mechanically expand into expanded articles upon contact with a liquid, individual expanded articles have a lateral dimension and a longitudinal dimension greater than the lateral dimension, and wherein a volume of the expanded articles is at least 4 times a volume of the liquid-expandable articles.
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이 특허에 인용된 특허 (4)
Fallon Timothy J. ; Maresh John G. ; Wilkie James A., Apparatus for applying a hemostatic agent onto a tissue.
Dowling, Matthew; Hess, John; Bochicchio, Grant; Raghavan, Srinivasa, Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells.
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