The invention relates to a dental composition for detecting bacteria comprising a solvent, at least one electron acceptor component and at least one electron donor component, the composition being substantially free of components which enable or facilitate the electron transmission between the elect
The invention relates to a dental composition for detecting bacteria comprising a solvent, at least one electron acceptor component and at least one electron donor component, the composition being substantially free of components which enable or facilitate the electron transmission between the electron acceptor component and the electron donor component. The invention also relates to a kit of parts and the use of the dental composition for producing a means for the inter-oral detection of bacteria.
대표청구항▼
1. A dental composition for detecting bacteria comprising a solventat least one electron acceptor component andat least one electron donor component,the composition being free of components which enable or facilitate the electron transmission between the electron acceptor component and the electron
1. A dental composition for detecting bacteria comprising a solventat least one electron acceptor component andat least one electron donor component,the composition being free of components which enable or facilitate the electron transmission between the electron acceptor component and the electron donor component. 2. The composition according to claim 1, wherein the electron acceptor component and the electron donor component are selected such that in the solution itself the electron donor can not transmit reduction equivalents to the electron acceptor. 3. The dental composition according to claim 1, wherein the electron acceptor component has a color in its reduced state that is different from the color it has in its oxidized state and has at least in its reduced state a color in the range of about 380 nm to about 780 nm wave length of the spectrum. 4. The dental composition according to claim 1, wherein the electron acceptor component in its oxidized state has solubility of at least 0.01 wt.-% in the solution. 5. The dental composition according to claim 1, wherein the electron acceptor component in its reduced state precipitates from the solution. 6. The dental composition according to claim 1, containing the electron acceptor component in a concentration of about 0.01 to 80 wt.-% with respect to the total weight of the composition. 7. The dental composition according to claim 1, wherein the electron acceptor component is a tetrazolium compound or a tetrazolium derivative including 2,3,5-triphenyltetrazolium bromide, 2,3,5-triphenyltetrazolium chloride, 2,3,5-triphenyltetrazolium iodide, 3-(4,5-dimethyl)-2-thiazolyl(-2,5-diphenyl-2H)-tetrazolium bromide (MTT), 2,5-diphenyl-3-(1-naphthyl)tetrazolium chloride (Tetrazolium Violet) and/or 2,2′-bipheny-4,4′-dihylbis-(3,5-diphenyl-2H-terazolium)-dichloride (Tetrazolpurpur), or combinations and mixtures thereof. 8. The dental composition according to claim 1 wherein the electron donor component is selected from the group consisting of reduced nicotinamide adenine dinucleotide, reduced nicotinamide adenine dinucleotidephosphate, reduced flavine adenine dinucleotide, reduced flavine mononucleotide or a derivative thereof and combinations or mixtures thereof. 9. The dental composition according to claim 1 containing the electron donor component in a concentration of about 0.01 to 80 wt.-% with respect to the total weight of the composition. 10. The dental composition according to claim 1, comprising a quinone, an oxidized glutathione, cystine and/or an oxidized lipoic acid. 11. The dental composition according to claim 1, comprising one or more additives selected from the group containing colorants being different from the electron acceptor or electron donor components, rheology modifiers, stabilizers, preservatives, fillers and combinations or mixtures thereof. 12. The dental composition according to claim 1, wherein the electron acceptor component is present in a concentration of about 1.0 to about 3.5 mg/ml. 13. The dental composition according to claim 1 having a pH value of from about 7 to about 10. 14. The dental composition according to claim 1, wherein the composition is free of components which enable or facilitate the electron transmission between the electron acceptor component and the electron donor component, such that the composition exhibits a color change when in the presence of bacteria. 15. The dental composition according to claim 14, wherein the color change includes at least one of: a change from one color to another distinct color,a change from colorless to a color,a change from a color to colorless, anda change from a color or colorless to fluorescence. 16. Kit of parts for detecting bacteria comprising part A and part B, part A comprising the electron acceptor component and part B comprising the electron donor component, wherein the solvent and optional additive(s) or optional auxiliary colorant(s) are present either in part A or part B or in part A and part B and wherein the electron acceptor component, the electron donor component, and the solvent are as described in claim 1. 17. A method for detecting bacteria, the method comprising: providing the dental composition of claim 1; andapplying the dental composition intra-orally. 18. The method of claim 17, wherein applying the dental composition intra-orally includes applying the dental composition to at least one of gingiva, tongue, enamel, dentin, root cement, dental restorations, plaques, dental calculus, and a combination thereof. 19. The method of claim 17, further comprising detecting bacteria, if present, intra-orally with site-directed localization. 20. The method of claim 17, further comprising detecting whether a color change occurs in the dental composition in 4 min. or less after applying the dental composition intra-orally.
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이 특허에 인용된 특허 (7)
Shibuya Mutsumi (Yokohama JPX) Matsumoto Kiyoyuki (Hachioji JPX), Device for rapid diagnosis of dental caries.
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