Medical devices having multiple charged layers
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/915
A61F-002/91
A61L-027/28
A61L-027/54
A61L-015/46
A61L-031/08
A61L-031/16
A61F-002/00
출원번호
US-0322905
(2005-12-30)
등록번호
US-8834912
(2014-09-16)
발명자
/ 주소
Atanasoska, Liliana
Weber, Jan
Shippy, III, James Lee
출원인 / 주소
Boston Scientific Scimed, Inc.
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
0인용 특허 :
15
초록▼
According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include th
According to an aspect of the present invention, medical devices are provided, which are adapted for implantation or insertion into a subject and which include at least one multilayer region that contains multiple charged layers of alternating charge. The multiple charged layers, in turn, include the following: (i) at least one charged block copolymer (e.g., a charged block copolymer that contains one or more polyelectrolyte blocks) and (ii) at least one charged therapeutic agent (e.g., a charged therapeutic agent that contains one or more polyelectrolyte blocks).
대표청구항▼
1. A medical device comprising: (a) a substrate; (b) a multilayer region comprising multiple charged layers of alternating charge deposited by layer-by-layer electrostatic self-assembly over said substrate, said multiple charged layers comprising (i) a plurality of first charged layers that comprise
1. A medical device comprising: (a) a substrate; (b) a multilayer region comprising multiple charged layers of alternating charge deposited by layer-by-layer electrostatic self-assembly over said substrate, said multiple charged layers comprising (i) a plurality of first charged layers that comprise a charged block copolymer that comprises a polyelectrolyte block, wherein said block copolymer comprises a polyisobutylene block and a charged poly(vinyl aromatic) block selected from sulfonated poly(vinyl aromatic) blocks and amine-modified-poly(vinyl aromatic) blocks, and (ii) a plurality of second charged layers that comprise a charged therapeutic agent that comprises a covalently linked polyelectrolyte block, wherein said medical device is configured for implantation or insertion into a patient, with the proviso that said medical device does not comprise two or more electrodes, wherein said charged therapeutic agent is a paclitaxel prodrug, wherein said charged therapeutic agent comprises a covalently linked charged poly(amino acid) portion, wherein said plurality of first charged layers comprise a plurality of positively charged layers that comprise a positively charged block copolymer which comprises said amine-modified-poly(vinyl aromatic) block and said polyisobutylene block, wherein said plurality of first charged layers comprise a plurality of negatively charged layers that comprise a negatively charged block copolymer which comprises said sulfonated poly(vinyl aromatic) block and said polyisobutylene block, wherein said multilayer region has a total thickness of between 10 nanometers 40 microns. 2. The medical device of claim 1, wherein said multilayer region comprises at least 10 of said charged layers of alternating charge. 3. The medical device of claim 1, wherein said multilayer region comprises at least 25 of said charged layers of alternating charge. 4. The medical device of claim 1, wherein said first and second charged layers are of opposite charge. 5. The medical device of claim 1, wherein said first and second charged layers are of the same charge. 6. The medical device of claim 1, wherein said charged block copolymer comprises a plurality of said polyelectrolyte blocks. 7. A medical device comprising: (a) a substrate; (b) a multilayer region comprising multiple charged layers of alternating charge deposited by layer-by-lager electrostatic self-assembly over said substrate, said multiple charged layers comprising (i) a plurality of first charged layers that comprise a charged block copolymer that comprises a polyelectrolyte block, wherein said block copolymer comprises a polyisobutylene block and a charged poly(vinyl aromatic) block selected from sulfonated poly(vinyl aromatic) blocks and amine-modified-poly(vinyl aromatic) blocks, and (ii) a plurality of second charged layers that comprise a charged therapeutic agent that comprises a covalently linked polyelectrolyte block, wherein said medical device is configured for implantation or insertion into a patient, with the proviso that said medical device does not comprise two or more electrodes, wherein said charged therapeutic agent comprises a covalently linked charged poly(amino acid) portion, wherein said charged therapeutic agent is a paclitaxel prodrug, wherein said block copolymer comprises said polyisobutylene block as a center block and a plurality of said sulfonated poly(vinyl aromatic) blocks as end blocks, wherein said multilayer region has a total thickness of between 10 nanometers 40 microns. 8. The medical device of claim 1, wherein said block copolymer comprises said amine-modified poly(vinyl aromatic) block and said polyisobutylene block. 9. The medical device of claim 1, wherein said charged therapeutic agent comprises a polycationic block. 10. The medical device of claim 1, wherein said charged therapeutic agent comprises a polyanionic block. 11. The medical device of claim 1, wherein said poly(amino acid) portion is selected from a polyglutamate portion, a polyaspartate portion, a polylysine portion, a polyarginine portion and a polyornithine portion. 12. The medical device of claim 1, wherein said plurality of second charged layers comprise a plurality of positively charged layers that comprise a positively charged therapeutic agent. 13. The medical device of claim 1, wherein said plurality of second charged layers comprise a plurality of negatively charged layers that comprise a negatively charged therapeutic agent. 14. The medical device of claim 1, wherein said medical device comprises a plurality of therapeutic agents. 15. The medical device of claim 1, wherein said multilayer region is bioerodable. 16. The medical device of claim 1, wherein said medical device comprises a plurality of distinct multilayer regions. 17. The medical device of claim 1, wherein said medical device is selected from a balloon catheter, a guidewire, a stent, a graft, and a filter. 18. The medical device of claim 1, further comprising a plurality of third charged layers that comprise a polyelectrolyte that is neither a block copolymer nor a therapeutic agent. 19. The medical device of claim 1, wherein said multilayer region comprises charged particles. 20. The medical device of claim 1, wherein said charged particles comprise a therapeutic agent. 21. The medical device of claim 1, further comprising a third charged layer that comprises a polyelectrolyte that is neither a block copolymer nor a therapeutic agent. 22. The medical device of claim 1, further comprising a third charged layer that comprises chitosan. 23. The medical device of claim 1, further comprising a third charged layer that comprises a proteoglycan. 24. The medical device of claim 1, wherein said medical device is a stent. 25. A stent comprising: (a) a substrate; (b) a multilayer region comprising at least 10 layers of alternating charge deposited by layer-by-layer electrostatic self-assembly over said substrate, said multiple charged layers comprising (i) a plurality of first charged layers that comprise a charged sulfonated polystyrene-polyolefin-polystyrene triblock copolymer, an amine-modified polystyrene-polyolefin-polystyrene triblock copolymer, or a combination thereof, (ii) a plurality of second charged layers that comprise a charged therapeutic agent that comprises a covalently linked charged poly(amino acid) portion and (iii) a plurality of third charged layers that comprise a polycationic polysaccharide that is neither a block copolymer nor a therapeutic agent, with the proviso that said stent does not comprise two or more electrodes, the multilayer region having a total thickness of between 10 nanometers 40 microns. 26. The medical device of claim 25, wherein said charged therapeutic agent is an anti-restenosis agent. 27. The medical device of claim 1, wherein said charged block copolymer comprises a polyisobutylene block and a polystyrene sulfonate block, and wherein said charged therapeutic agent comprises a covalently linked charged poly(amino acid) portion. 28. The medical device of claim 27, wherein said therapeutic agent is an antiproliferative agent.
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