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특허 상세정보

Materials and methods related to sodium/potassium adenosine triphosphase and cholesterol

국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) G01N-033/92    C12Q-001/34    G01N-033/50   
미국특허분류(USC) 435/375; 435/007.1; 435/007.4
출원번호 US-0521864 (2011-01-13)
등록번호 US-8835171 (2014-09-16)
국제출원번호 PCT/US2011/021127 (2011-01-13)
§371/§102 date 20120802 (20120802)
국제공개번호 WO2011/088208 (2011-07-21)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    MacMillan, Sobanski & Todd, LLC
인용정보 피인용 횟수 : 0  인용 특허 : 17

This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase inte...


1. A method to affect cholesterol transport in a cell, comprising: administering to the cell a composition of matter comprising an amino acid compound of 17 residues comprising at least ten consecutive amino acid residues of a cholesterol recognition/interaction amino acid sequence and consensus pattern (CRAC) sequence having SEQ ID NO:2, or conservative substitutions of the at least ten consecutive amino acid residues of SEQ ID NO:2, wherein the compound is capable of binding cholesterol and affecting sodium/potassium adenosine triphosphate synthase (Na...

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