A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
대리인 / 주소
Evans, Susan T.
인용정보
피인용 횟수 :
8인용 특허 :
209
초록▼
A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility a
A composition is provided, wherein the composition comprises a water-swellable, water-insoluble polymer, a blend of a hydrophilic polymer and a complementary oligomer capable of hydrogen bonding to the hydrophilic polymer, and a whitening agent, preferably a peroxide. The composition finds utility as a tooth whitening composition and is applied to the teeth in need of whitening, and then removed when the degree of whitening has been achieved. In certain embodiments, the composition is translucent. Methods for preparing and using the compositions are also disclosed.
대표청구항▼
1. An in-vivo film forming liquid teeth whitening composition comprising: (a) 2-6 wt % of a water-swellable, water-insoluble acrylate-based polymer or copolymer comprising monomers selected from acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, and ethyl methacryl
1. An in-vivo film forming liquid teeth whitening composition comprising: (a) 2-6 wt % of a water-swellable, water-insoluble acrylate-based polymer or copolymer comprising monomers selected from acrylic acid, methacrylic acid, methyl acrylate, ethyl acrylate, methyl methacrylate, and ethyl methacrylate;(b) 4-10 wt % of a poly(N-vinyl lactam);(c) 0.5-10 wt % of a polyalkylene glycol having a molecular weight ranging from about 300 to about 600 daltons, and(d) 1-30 wt % of a whitening agent,dissolved in a solvent mixture comprising water and a lower alcohol,wherein, the liquid composition upon application to the surface of the teeth and evaporation of the lower alcohol, forms a hydrogel film that is insoluble or slowly soluble in saliva at body temperature to thereby remain on the teeth surface for a period of over at least 10 minutes. 2. The composition of claim 1 wherein the water-swellable, water-insoluble copolymer is a copolymer of methacrylic acid and methyl methacrylate or is a copolymer of methacrylic acid and ethyl acrylate. 3. The composition of claim 1, wherein the acrylate-based polymer or copolymer is selected from the group consisting of (dimethylaminoethyl methacrylate-butyl methacrylate-methyl methacrylate copolymers, methacrylic acid-methyl methacrylate copolymers, 1:1, methacrylic acid-methyl methacrylate copolymers, 1:2, ethyl acrylate-methyl methacrylate-methacrylic acid ester with quaternary ammonium groups copolymers, 1:2:0.2, ethyl acrylate-methyl methacrylate-methacrylic acid ester with quaternary ammonium groups copolymers, 1:2:0.1 and ethyl acrylate-methyl methacrylate copolymers, 2:1). 4. The composition of claim 3, wherein the acrylate-based polymer or copolymer is a methacrylic acid-methyl methacrylate copolymer. 5. The composition of claim 4, wherein the copolymer has a ratio of free carboxyl groups to ester groups in the range of about 1:1 to 1:2. 6. The composition of claim 1, wherein the poly(N-vinyl lactam) is selected from the group consisting of polyvinyl pyrrolidone, polyvinyl caprolactam, and blends thereof. 7. The composition of claim 6, wherein the poly(N-vinyl lactam) is polyvinyl pyrrolidone. 8. The composition of claim 6, wherein the poly(N-vinyl lactam) is polyvinyl caprolactam. 9. The composition of claim 1, wherein the poly(N-vinyl lactam) has a number average molecular weight in the range of approximately 100,000 to 2,000,000. 10. The composition of claim 9, wherein the poly(N-vinyl lactam) has a number average molecular weight in the range of approximately 500,000 to 1,500,000. 11. The composition of claim 1, wherein the polyalkylene glycol has a molecular weight of about 400. 12. The composition of claim 1, wherein the polyalkylene glycol is selected from the group consisting of carboxyl-terminated polyalkylene glycols and amino-terminated polyalkylene glycols. 13. The composition of claim 12, wherein the polyalkylene glycol is selected from the group consisting of polyethylene glycol and carboxyl-terminated polyethylene glycol. 14. The composition of claim 13, wherein the polyalkylene glycol is polyethylene glycol. 15. The composition of claim 1, wherein the whitening agent is selected from the group consisting of peroxides, metal chlorites, perborates, percarbonates, peroxyacids, and combinations thereof. 16. The composition of claim 15, wherein the whitening agent is a peroxide selected from the group consisting of hydrogen peroxide, calcium peroxide, carbamide peroxide, and mixtures thereof. 17. The composition of claim 15, wherein the peroxide is an organic peroxide. 18. The composition of claim 17, wherein the organic peroxide is selected from the group consisting of dialkyl peroxides, diacyl peroxides, peresters, perdicarbonates, ketone peroxides, and hydroperoxides. 19. The composition of claim 18, wherein the dialkyl peroxide is t-butyl peroxide or 2,2 bis(t-butylperoxy)propane. 20. The composition of claim 18, wherein the diacyl peroxide is benzoyl peroxide or acetyl peroxide. 21. The composition of claim 18, wherein the perester is t-butyl perbenzoate or t-butyl per-2-ethylhexanoate. 22. The composition of claim 18, wherein the perdicarbonate is dicetyl peroxy dicarbonate or dicyclohexyl peroxy dicarbonate. 23. The composition of claim 18, wherein the ketone peroxide is cyclohexanone peroxide or methylethylketone peroxide. 24. The composition of claim 18, wherein the hydroperoxide is cumene hydroperoxide or tert-butyl hydroperoxide. 25. The composition of claim 1, further comprising a flavorant. 26. The composition of claim 25, wherein the flavorant is selected from the group consisting of wintergreen, peppermint, spearmint, menthol, fruit flavors, vanilla, cinnamon, spices, flavor oils and oleoresins, and combinations thereof. 27. The composition of claim 1, further comprising a sweetener selected from the group consisting of sucrose, fructose, aspartame, xylitol and saccharine. 28. The composition of claim 1, further comprising at least one additive selected from the group consisting of fillers, preservatives, pH regulators, softeners, thickeners, colorants, pigments, dyes, refractive particles, flavorants, sweeteners, stabilizers, toughening agents, detackifiers, and permeation enhancers. 29. The composition of claim 1, wherein the composition is translucent. 30. The composition of claim 28, which further comprises an absorbent filler. 31. A method for whitening teeth comprising: applying the composition of claim 1 to at least a portion of the surface of one or more teeth, and maintaining the composition on the surface of the one or more teeth for a desired period of time, to thereby achieve a desired degree of whitening. 32. The method of claim 31, wherein the desired period of time is predetermined. 33. The method of claim 32, wherein the predetermined period of time is from about 10 minutes to about 24 hours. 34. The method of claim 33, wherein the predetermined period of time is from about 10 minutes to about 8 hours. 35. The method of claim 34, wherein the predetermined period of time is about 30 minutes to 1 hour. 36. The method of claim 31, wherein the composition is applied by the user. 37. The method of claim 31, wherein the composition is applied by finger, directly from a container comprising the composition, by brush or by applicator. 38. The composition of claim 1, wherein the composition forms a continuous integrated viscous swollen gel coating separated from a liquid solution by a sharp phase boundary upon contact with aqueous media when characterized in-vitro by wedge microinterferometry. 39. The composition of claim 1, wherein the solvent mixture comprises water and ethanol. 40. The method of claim 31, further comprising, after the maintaining step, removing the hydrogel film composition from the surface of the one or more teeth. 41. The method of claim 40, wherein the removing is by dissolution of the hydrogel film composition in saliva over time. 42. The method of claim 40, wherein the removing is by conventional tooth cleansing methods. 43. The liquid composition of claim 1, wherein components of the composition are miscible upon solvent evaporation.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (209)
Meconi Reinhold,DEX ; Seibertz Frank,DEX, Active substance-containing patch.
Schiraldi Michael T. (East Brunswick NJ) Perl Martin M. (Brooklyn NY) Rubin Howard (Rockaway NJ), Bioadhesive extruded film for intra-oral drug delivery and process.
Anderson John McCune (16 Torgrange Holywood ; County Down ; BT18 ONG ; Northern Ireland GBX) McAdams Eric Thomas (Ormsdale ; 52 Cable Road Whitehead ; County Antrim ; Northern Ireland BT38 9 PZ GBX) , Biomedical electrode device.
Arraudeau Jean-Pierre (Paris FRX) Patraud Jeanne (Paris FRX) Le Gall Louis (Bures-sur-Yvette FRX), Composition based on cationic polymers, anionic polymers and waxes for use in cosmetics.
Takoh Noboru,JPX ; Kondo Masahiro,JPX ; Inoue Hiroshi,JPX, Composition used for hydrophilization and method for hydrophilization using said composition.
Kanios David P. ; Gentile Joseph A. ; Mantelle Juan A. ; Sablotsky Steven, Compositions and methods for topical administration of pharmaceutically active agents.
Bloom Roberta C. (Huntington CT) Deckner George E. (Cincinnati OH), Compositions for topical delivery of drugs comprising a mixture of high and low HLB surfactants and alkoxylated ether.
Lee Eun Soo (Redwood City CA) Theeuwes Felix (Los Altos Hills CA) Wong S. L. Patrick (Hayward CA) Yum Su Il (Los Altos CA) Zaffaroni Alejandro (Atherton CA), Delayed onset transdermal delivery device.
Sagel Paul A. ; Dirksing Robert S. ; Rohman Frederick J., Delivery system for a tooth whitener using a strip of material having low flexural stiffness.
Sagel Paul Albert ; Dirksing Robert Stanley ; Rohman Frederick James, Delivery system for a tooth whitener using a strip of material having low flexural stiffness.
Dirksing Robert S. ; Sagel Paul A. ; Tweddell ; III Richard, Delivery system for an oral care substance using a permanently deformable strip of material.
Sagel Paul A. ; Dirksing Robert S. ; Rohman Frederick J., Delivery system for an oral care substance using a strip of material having low flexural stiffness.
Sagel Paul Albert ; Dirksing Robert Stanley ; Rohman Frederick James ; Majeti Satyanarayana ; Reno Elizabeth Ann, Delivery system for an oral care substance using a strip of material having low flexural stiffness.
Curtis John (Bloomsbury NJ) Nahoo Salim (Piscataway NJ) Prencipe Michael (E. Windsor NJ), Dental material and method for applying preventative and therapeutic agents.
Chang Yunik (Toms River NJ) Patel Dinesh C. (Murray UT) Ebert Charles D. (Salt Lake City UT), Device for administering an active agent to the skin or mucosa.
Chang Yunik (Toms River NJ) Patel Dinesh C. (Murray UT) Ebert Charles D. (Salt Lake City UT), Device for administering an active agent to the skin or mucosa.
Gyory J. Richard (Los Altos CA) Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Lew Patrick J. (Mountain View CA), Electrotransport adhesive.
Tseng Susan Y. (Staten Island NY) Wolf Philip F. (Bridgewater NJ) Burlant William J. (Wayne NJ), Films and extrusions of cured crosslinked vinyl lactam polymer and method of preparation.
Roreger Michael (Neuwied DEX) Herrmann Fritz (Neuwied DEX) Hoffmann Hans-Rainer (Neuwied DEX) List Harald (Neuwied DEX), Flexible, hydrophilic gel film, the process for its production and the use of it.
Holmblad Carolann M. (Cambridge MN) Bergstrom Joan M. (Minneapolis MN) Bartlett Terese A. (Circle Pines MN), Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs.
Jevne Allan H. (Anoka MN) Vegoe Brett R. (Brooklyn Park MN) Holmblad Carolann M. (Cambridge MN) Cahalan Patrick T. (Champlin MN), Hydrophilic pressure sensitive biomedical adhesive composition.
Nielsen Kent E.,CAX ; Li Kai,CAX ; Kantner Steven S. ; Koski Nancy L. ; Everaerts Albert I., Ionically conductive adhesives prepared from zwitterionic materials and medical devices using such adhesives.
Gyory J. Richard (Los Altos CA) Haak Ronald P. (Cupertino CA) Theeuwes Felix (Los Altos CA) Lew Patrick J. (Mountain View CA), Iontophoretic device incorporating an electrotransport adhesive.
Samour Carlos ; Krauser Scott F., Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery.
Broberg Berndt F. J. (Sdertlje SEX) Evers Hans C. A. (Sdertlje SEX), Local anesthetic mixture for topical application and method for obtaining local anesthesia.
Broberg, Berndt F. J.; Evers, Hans C. A., Local anesthetic mixture for topical application, process for its preparation, as well as method for obtaining local anesthesia.
Itoh Steven K. (Cottage Grove MN) Dietz Timothy M. (St. Paul MN) Uy Rosa (St. Paul MN), Low impedance pressure sensitive adhesive composition and biomedical electrodes using same.
Barton James Bradbury ; Shari Joy Soper ; Joseph Robert Kaczvinsky, Jr. ; Dorothy Limerick Bailey ; Celeste Dawn Gale, Method for regulating hair growth.
Gleich Gerald J. (Rochester MN) Ohnishi Tsukasa (Tokyo JPX) Hunt Loren W. (Rochester MN), Method for the treatment of eosinophil-associated diseases by administration of topical anesthetics.
Hofmann Gunter A. ; Dev Sukhendu B. ; Dimmer Steven C. ; Levatter Jeffrey I. ; Nanda Gurvinder S., Method of Selectively applying needle array configurations.
Tucker Mark J. (Round Steps ; High Street Stow-on-the-Wold ; Gloucester GL54 1DL GBX) Tucker Mark R. (P.O. Box 23530 Bahrain BHX), Occlusive body for administering a physiologically active substance.
Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
Lerner E. Itzhak,ILX ; Rosenberger Vered,ILX ; Flashner Moshe,ILX, Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity.
Dietz Timothy M. (St. Paul MN) Lu Ying-Yuh (Woodbury MN) Uy Rosa (St. Paul MN) Young Chung I. (Roseville MN), Polymerized microemulsion pressure sensitive adhesive compositions and methods of preparing and using same.
Feldstein, Mikhail M.; Plate, Nicolai A.; Chalykh, Anatoly E.; Cleary, Gary W., Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties.
Therriault Donald J. (Lowell MA) Temin Samuel C. (Needham MA) Shah Kishore R. (Bridgewater NJ), Pressure-sensitive hydrophilic laminate structures for use in wound dressing, transdermal and topical drug delivery.
Duan Daniel C. (St. Paul MN) Asmus Robert A. (Township of Hudson ; County of St. Croix WI) Dietz Timothy M. (St. Paul MN) Uy Rosa (St. Paul MN) Benson ; Jr. Olester (Woodbury MN), Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same.
Plate Nicolai A.,RUX ; Valuev Lev I.,RUX ; Uzhinova Lubov D.,RUX ; Sinani Vladimir A.,RUX, Process for preparing biologically compatible polymers and their use in medical devices.
Pfister William R. (Bay City MI) Wilson Jeniffer M. (Saginaw MI), Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices.
Lee Eun Soo (Redwood City CA) Nedberge Diane E. (Los Altos CA) Yum Su Il (Los Altos CA), Skin permeation enhancer compositions using glycerol monolinoleate.
Chiang Chia-Ming (Foster City CA) Cleary Gary W. (San Mateo CA), Skin permeation enhancer compositions, and methods and transdermal systems associated therewith.
Miranda Jesus (Miami FL) Sablotsky Steven (Miami FL), Solubility parameter based drug delivery system and method for altering drug saturation concentration.
Wagner Julie Ann ; Zukowski Joseph Michael ; Robinson Larry Richard ; Deckner George Endel ; Rinaldi Marie Antoinette ; Szymanski Victoria Claire, Stable topical compositions.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Turner Josephine S. (Kettleby CAX) Murray D. Gary (Willowdale CAX) Zuccolin John D. (Stouffville CAX) Li Ruey S. (Thornhill CAX), Substance transfer system for topical application.
Gale Robert M. (Los Altos CA) Nedberge Diane E. (Los Altos CA) Atkinson Linda E. (Portola Valley CA), Transdermal contraceptive formulations, methods and devices.
Min Dong Son,KRX ; Um Kee An,KRX ; Kim Yong Soo,KRX ; Park Pyeong Uk,KRX ; Kim Key Hyup,KRX ; Yang Ho Seung,KRX ; Jeong Hey Soon,KRX ; Park Mi Young,KRX, Transdermal delivery matrix for piroxicam.
Ebert Charles D. (Salt Lake City UT) Heiber Werner (Salt Lake City UT) Good William R. (Salt Lake City UT) Venkateshwaran Srinivasan (Salt Lake City UT), Transdermal delivery system with adhesive overlay and peel seal disc.
Chiang Chia-Ming (Foster City CA) Colley Kenneth J. (Washington DC) Cleary Gary W. (San Mateo CA), Transdermal drug delivery device using an unfilled microporous membrane to achieve delayed onset.
Ma Xinghang ; Audett Jay ; Soni Pravin L. ; Singh Noel ; Bailey Susan E., Transdermal drug delivery sytem for the administration of tamsulosin, and related compositions and methods of use.
Chien Yie W. (North Brunswick NJ) Chien Te-Yen (Piscataway NJ) Huang Yih-Chain (Piscataway NJ), Transdermal estrogen/progestin dosage unit, system and process.
Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
Jona Janan ; Audett Jay ; Singh Noel, Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen.
Horstmann Michael (Neuwied DEX) Herrmann Fritz (Neuwied DEX), Transdermal therapeutic system exhibiting an increased active substance flow and process for the production thereof.
Kleinsorgen Reinhard v.,DEX ; Kleinsorgen Britta v.,DEX, Transdermal therapeutic system with small application-area thickness and great flexibility, and production process.
Jan A. Orlowski ; David V. Butler, Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals.
Dietz Timothy M. (St. Paul MN) Asmus Robert A. (Hudson WI) Uy Rosa (St. Paul MN), Two-phase composites of ionically-conductive pressure-sensitive adhesive, biomedical electrodes using the composites, an.
Login Robert B. (Oakland NJ) Merianos John J. (Middletown NJ) Biss Russell B. (Paramus NJ) Garelick Paul (South Plainfield NJ), Urea-hydrogen peroxide-polyvinylpyrrolidone.
Login Robert B. (Oakland NJ) Merianos John J. (Middletown NJ) Biss Russell B. (Wayne NJ) Garelick Paul (South Plainfield NJ), Urea-hydrogen peroxide-polyvinylpyrrolidone process.
Kantner Steven S. ; Kuester Wilhelm,DEX, Use of pendant free-radically polymerizable moieties with polar polymers to prepare hydrophilic pressure sensitive adhes.
Gaglio Thomas J. (4421 La Paloma Santa Barbara CA 93105) Santoriello Luigi (3463 State St. ; #359 Santa Barbara CA 93105), Viscous fluid dispensing apparatus.
Kim Son Nguyen,DEX ; Sanner Axel,DEX ; Hossel Peter,DEX ; Schehlmann Volker,DEX, Water-soluble or water-dispersible graft copolymers based on a polyvinyllactam, their preparation and use.
Biegajski James E. (Foster City CA) Venkatraman Subbu S. (Palo Alto CA) Scott Ann M. (Mountain View CA), Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavi.
Beier Helmut (Darmstadt DEX) Petereit Hans-Ulrich (Darmstadt DEX) Bergmann Gunter (Hanau DEX), Water-soluble pressure-sensitive skin adhesive, its use, and agents provided with it.
Singh, Parminder; Cleary, Gary W.; Mudumba, Sri; Feldstein, Mikhail M.; Bairamov, Danir R., Hydrogel compositions demonstrating phase separation on contact with aqueous media.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.