Methods and systems for providing therapies into the pericardial space
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/22
A61B-017/34
A61M-005/142
A61M-005/172
A61B-018/00
A61B-017/00
A61B-017/22
A61B-018/14
A61M-005/14
출원번호
US-0273521
(2011-10-14)
등록번호
US-8852173
(2014-10-07)
발명자
/ 주소
Sigg, Daniel C.
Ujhelyi, Michael R.
Morris, Mary M.
출원인 / 주소
Medtronic, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
71
초록▼
Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an inf
Methods and systems for transvenously accessing the pericardial space via the vascular system and atrial wall, particularly through the superior vena cava and right atrial wall, to deliver a pharmacologic agent, particularly a NO-donor drug, to the heart are disclosed. A proximal connector of an infusion catheter is coupled to an infusion pump, and a distal catheter segment having a distal infusion catheter lumen end opening is disposed in the pericardial space. The implantable infusion pump is operable in conjunction with an implantable ischemia monitor to monitor the ischemic state and trigger delivery or regulate the periodic delivery of the pharmacologic agent to optimally treat ischemia. The patient may operate a patient activator that the patient when feeling ischemia symptoms to transmit a signal that is received by the implantable infusion pump and triggers delivery of a bolus and/or continuous infusion.
대표청구항▼
1. A method of accessing the pericardial space between a heart and its pericardium to deliver a pharmacologic agent for the treatment of ischemia to the heart, the method comprising the steps of: advancing an infusion catheter to dispose a distal catheter segment having a distal infusion catheter lu
1. A method of accessing the pericardial space between a heart and its pericardium to deliver a pharmacologic agent for the treatment of ischemia to the heart, the method comprising the steps of: advancing an infusion catheter to dispose a distal catheter segment having a distal infusion catheter lumen end opening in the pericardial space;attaching a proximal connector of the infusion catheter to an infusion pump having a reservoir containing the pharmacologic agent;detecting an ischemic state of the heart; anddelivering the pharmacologic agent for the treatment of ischemia from the reservoir into the pericardial space to counter the detected ischemic state. 2. The method of claim 1, further comprising: detecting a remotely transmitted therapy delivery command; anddelivering a bolus of the pharmacologic agent. 3. The method of claim 2, wherein the pharmacologic agent comprises NO-donor drugs selected from the group consisting of nitroglycerin, isosorbide mononitrate, sodium nitroprusside, a diazenium diolate, an NO aspirin, an S-Nitrosothiol, morpholinosydnonimime and L-arginin. 4. The method of claim 1, wherein the detecting step comprises: sensing a feature of the EGM of the heart; anddetecting a characteristic of the sensed feature indicative of the ischemic state. 5. The method of claim 4, wherein the pharmacologic agent comprises NO-donor drugs selected from the group consisting of nitroglycerin, isosorbide mononitrate, sodium nitroprusside, a diazenium diolate, an NO aspirin, an S-Nitrosothiol, morpholinosydnonimime and L-arginin. 6. The method of claim 1, wherein the detecting step comprises: sensing blood pH; anddetecting a value of the sensed blood pH indicative of the ischemic state. 7. The method of claim 6, wherein the pharmacologic agent comprises NO-donor drugs selected from the group consisting of nitroglycerin, isosorbide mononitrate, sodium nitroprusside, a diazenium diolate, an NO aspirin, an S-Nitrosothiol, morpholinosydnonimime and L-arginin. 8. The method of claim 1, wherein the detecting step comprises: sensing blood oxygen saturation; anddetecting a value of the sensed oxygen saturation indicative of the ischemic state. 9. The method of claim 8, wherein the pharmacologic agent comprises NO-donor drugs selected from the group consisting of nitroglycerin, isosorbide mononitrate, sodium nitroprusside, a diazenium diolate, an NO aspirin, an S-Nitrosothiol, morpholinosydnonimime and L-arginin. 10. The method of claim 1, wherein the detecting step comprises: sensing one or both of blood pressure and flow in the heart; anddetecting a value of the sensed one or both of blood pressure and flow indicative of the ischemic state. 11. The method of claim 10, wherein the pharmacologic agent comprises NO-donor drugs selected from the group consisting of nitroglycerin, isosorbide mononitrate, sodium nitroprusside, a diazenium diolate, an NO aspirin, an S-Nitrosothiol, morpholinosydnonimime and L-arginin. 12. A method of transvenously accessing the pericardial space between a heart and its pericardium to deliver a NO-donor drug to the heart, the method comprising the steps of: advancing an infusion catheter to dispose a distal catheter segment having a distal infusion catheter lumen end opening in the pericardial space;attaching a proximal connector of the infusion catheter to an infusion pump;detecting a condition of the heart; anddelivering a bolus of NO-donor drug. 13. The method of claim 12, further comprising: detecting a remotely transmitted therapy delivery command; anddelivering a bolus of the NO-donor drug. 14. The method of claim 12, wherein the detecting step comprises: sensing a feature of the EGM of the heart; anddetecting a characteristic of the sensed feature indicative of an ischemic state. 15. The method of claim 12, wherein the detecting step comprises: sensing blood pH; anddetecting a value of the sensed blood pH indicative of an ischemic state. 16. The method of claim 12, wherein the detecting step comprises: sensing blood oxygen saturation; anddetecting a value of the sensed oxygen saturation indicative of an ischemic state. 17. The method of claim 12, wherein the detecting step comprises: sensing one or both of blood pressure and flow in the heart; anddetecting a value of the sensed one or both of blood pressure and flow indicative of an ischemic state. 18. The method of claim 12, wherein the advancing step comprises: passing a fixation catheter having a fixation catheter lumen extending between proximal and distal fixation catheter lumen openings and a distal tissue fixation mechanism through a selected peripheral vein and one of the inferior vena cava and the superior vena cava to establish a transvenous route into the right atrium of the heartdisposing the distal fixation mechanism and distal fixation catheter lumen opening proximate the right atrial wall;affixing the distal fixation mechanism to the right atrial wall;passing an infusion catheter through the fixation catheter lumen out of the distal fixation catheter lumen opening and through the stabilized atrial wall to dispose a distal catheter segment having a distal infusion catheter lumen end opening in the pericardial space. 19. The method of claim 12, wherein the advancing step comprises advancing the distal catheter segment from the right atrium through the right atrial wall. 20. The method of claim 12, wherein the NO-donor drug is selected from the group consisting of nitroglycerin, isosorbide mononitrate, sodium nitroprusside, a diazenium diolate, an NO aspirin, an S-Nitrosothiol, morpholinosydnonimime and L-arginin. 21. The method of claim 1, wherein detecting an ischemic state of the heart comprises detecting acute reversible myocardial ischemia, chronic therapy refractory angina pectoris, acute myocardial infarction, subacute myocardial infarction, silent ischemia, or vasospastic angina. 22. The method of claim 12, wherein detecting a condition of the heart comprises detecting acute reversible myocardial ischemia, chronic therapy refractory angina pectoris, acute myocardial infarction, subacute myocardial infarction, silent ischemia, or vasospastic angina.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (71)
Blaisdell Michael W. ; Vidyarthi Piush ; Kramer Thomas A., Apparatus and method for accessing and manipulating the uterus.
Carney James K. (Eden Prairie MN), Apparatus and method for determining a plurality of hemodynamic variables from a single, chroniclaly implanted absolute.
de Coriolis Paul E. (Bellevue WA) Bocek Joseph M. (Seattle WA) Yomtov Barry M. (Issaquah WA), Atrial defibrillation system having a portable communication device.
Zacouto Fred (16 rue de la Convention 75 015 Paris FRX), Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemo.
Halperin Louis E. (St. Paul MN) Miesel Keith A. (St. Paul MN) Ufford Keith A. (Chisago City MN) Svensk James R. (Coon Rapids MN) Patrick Timothy (South St. Paul MN) Hassler Beth A. (White Bear Lake M, Implantable capacitive absolute pressure and temperature sensor.
Obel Israel W. P. (Johannesburg ZAX) Bourgeois Ivan (Verviers BEX), Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload.
Stadler, Robert W.; Combs, William J.; Lipson, David, Implantable medical device employing sonomicrometer output signals for detection and measurement of cardiac mechanical function.
Lawrence J. Mulligan ; D. Curtis Deno ; Tom D. Bennett ; David A. Igel ; Michael R. S. Hill, Implantable medical device for monitoring congestive heart failure.
Elliott Clyde D. (Mountain Brook AL) Cohen Donald M. (Encino CA), Method for transvenous implantation of objects into the pericardial space of patients.
Jeffrey E. Thomas, Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal.
Chin Yem ; McCrory Jennifer J. ; Tremaglio ; Jr. Anthony R. ; Guterman Lee R. ; Dassa Alyssa ; Hudson Richard, Removable occlusion system for aneurysm neck.
Jahns, Scott E.; Werness, Greg P.; Ocel, Jon M.; Lipson, David; Jensen, Donald N.; Francischelli, David E.; Keogh, James R., Suction stabilized epicardial ablation devices.
Alferness Clifton A. (2022 235th Pl. Redmond WA 98053), Vascular catheter assembly for tissue penetration and for cardiac stimulation and methods thereof.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.