초록 ▼

Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed. The particles may be used in the gastrointestinal

Rare earth metal compounds, particularly lanthanum, cerium, and yttrium, are formed as porous particles and are effective in binding metals, metal ions, and phosphate. A method of making the particles and a method of using the particles is disclosed. The particles may be used in the gastrointestinal tract or the bloodstream to remove phosphate or to treat hyperphosphatemia in mammals. The particles may also be used to remove metals from fluids such as water.

대표청구항 ▼

1. A method of producing a crystalline anhydrous lanthanum oxycarbonate comprising: (a) reacting lanthanum chloride in a solution with sodium carbonate at a temperature of 30 to 90 degrees centigrade to form a precipitate;(b) recovering the precipitate and washing and drying the precipitate; and(c)

1. A method of producing a crystalline anhydrous lanthanum oxycarbonate comprising: (a) reacting lanthanum chloride in a solution with sodium carbonate at a temperature of 30 to 90 degrees centigrade to form a precipitate;(b) recovering the precipitate and washing and drying the precipitate; and(c) thermally treating the precipitate of step (b) at a temperature of 400 to 700 degrees centigrade to produce the crystalline anhydrous lanthanum oxycarbonate; wherein said crystalline anhydrous lanthanum oxycarbonate is in the form of particles having a porous structure and having a BET specific surface area of at least about 10 m2/g or more, and wherein the crystalline anhydrous lanthanum oxycarbonate is selected from the group consisting of crystalline anhydrous La2O2CO3, crystalline anhydrous La2CO5, and a combination thereof. 2. The method of claim 1, wherein the reaction of the lanthanum chloride with the sodium carbonate is conducted at a temperature of between 80 and 90 degrees centigrade. 3. The method of claim 1, wherein the crystalline anhydrous lanthanum oxycarbonate is crystalline anhydrous La2O2CO3. 4. The method of claim 1, wherein the crystalline anhydrous lanthanum oxycarbonate is crystalline anhydrous La2CO5. 5. The method of claim 1, wherein the BET specific surface area is about 20 m2/g or more. 6. The method of claim 1, wherein the precipitate of step (b) is thermally treated at a temperature of 500 degrees centigrade in step (c), and wherein said crystalline anhydrous lanthanum oxycarbonate is crystalline anhydrous La2O2CO3. 7. The method of claim 1, wherein the precipitate of step (b) is thermally treated at a temperature of 600 degrees centigrade in step (c), and wherein said crystalline anhydrous lanthanum oxycarbonate is crystalline anhydrous La2CO5.