Antioxidants and antimicrobial accessories including antioxidants
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/00
A61K-009/00
A61K-038/12
A61K-031/7028
A61K-031/7036
A61K-031/65
A61P-041/00
A61P-031/04
A61P-043/00
A61L-027/18
A61L-027/54
출원번호
US-0725072
(2010-03-16)
등록번호
US-8858983
(2014-10-14)
발명자
/ 주소
Burgmeier, Robert E.
출원인 / 주소
Medtronic, Inc.
대리인 / 주소
Shumaker & Sieffert, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
36
초록▼
An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include an ascorbate peroxidase in co
An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, or a superoxide dismutase in combination with a metal such as Ni, Cu, Mn, or Fe. In some examples, the antimicrobial accessory may include at least three polymer layers. For example, the antimicrobial accessory may include a first layer comprising a biodegradable polymer and an antimicrobial. The antimicrobial accessory may further include a sacrificial diffusion layer formed on a surface of the first layer. The sacrificial diffusion layer may include a biodegradable polymer, which may be the same biodegradable polymer as in the first layer or may be a different biodegradable polymer. The antimicrobial accessory may also include a topcoat formed on the sacrificial diffusion layer. The topcoat may include a biodegradable polymer and at least one antioxidant mixed in the biodegradable polymer.
대표청구항▼
1. An antimicrobial accessory comprising: a first layer comprising a first biodegradable polymer and an antimicrobial;a sacrificial diffusion layer formed on the first layer, wherein the sacrificial diffusion layer comprises a second biodegradable polymer; anda topcoat formed on the sacrificial diff
1. An antimicrobial accessory comprising: a first layer comprising a first biodegradable polymer and an antimicrobial;a sacrificial diffusion layer formed on the first layer, wherein the sacrificial diffusion layer comprises a second biodegradable polymer; anda topcoat formed on the sacrificial diffusion layer, wherein the topcoat comprises a third biodegradable polymer and an antioxidant, wherein the topcoat defines a plurality of channels formed in the topcoat, wherein the plurality of channels extend from an outer surface of the topcoat to the sacrificial diffusion layer, and wherein the sacrificial diffusion layer is configured to substantially prevent mixing of the antioxidant and the antimicrobial in the sacrificial diffusion layer due to diffusion of the antioxidant from the topcoat into the sacrificial diffusion layer and diffusion of the antimicrobial from the first layer into the sacrificial diffusion layer. 2. The antimicrobial accessory of claim 1, wherein the antioxidant is selected from the group consisting of citric acid, maltol, kojic acid, malic acid, vitamin A, an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, a superoxide dismutase in combination with a metal, or combinations thereof. 3. The antimicrobial accessory of claim 1, wherein the antimicrobial is selected from the group consisting of minocycline, rifampin, clindamycin, tigecycline, daptomycin, gentamicin, another fluoroquinolone, an antiseptic, an antimicrobial peptide, a quaternary ammonium, or combinations thereof. 4. The antimicrobial accessory of claim 1, wherein at least one of the first biodegradable polymer, the second biodegradable polymer, and the third biodegradable polymer comprises a polymer selected from the group consisting of poly(lactic-co-glycolic acid), poly(lactic acid), poly(glycolic acid), poly(ethylene oxide), poly(ortho ester), poly(dioxanone) a hydrophilic hydrogel, a hydrophobic hydrogel, a polyanhydride, an amino acid polymer, or combinations thereof. 5. The antimicrobial accessory of claim 1, wherein at least two of the first biodegradable polymer, the second biodegradable polymer, and the third biodegradable polymer comprise the same biodegradable polymer. 6. The antimicrobial accessory of claim 1, wherein the first biodegradable polymer, the second biodegradable polymer, and the third biodegradable polymer each comprise a different biodegradable polymer. 7. The antimicrobial accessory of claim 1, wherein the sacrificial diffusion layer comprises a thickness of between approximately 0.5 times the thickness of the first layer and approximately 5 times the thickness of the first layer. 8. The antimicrobial accessory of claim 1, wherein the sacrificial diffusion layer comprises a plurality of channels extending from the topcoat to the first layer. 9. The antimicrobial accessory of claim 1, wherein the first layer comprises a first surface and a second surface, wherein the sacrificial diffusion layer comprises a first sacrificial diffusion layer and is formed on the first surface of the first layer, and wherein the antimicrobial accessory further comprises a second sacrificial diffusion layer formed on the second surface of the first layer and a base layer formed on the second sacrificial diffusion layer. 10. The antimicrobial accessory of claim 9, wherein the second sacrificial diffusion layer comprises a biodegradable polymer selected from the group consisting of poly(lactic-co-glycolic acid), poly(lactic acid), poly(glycolic acid), poly(ethylene oxide), poly(ortho ester), poly(dioxanone) a hydrophilic hydrogel, a hydrophobic hydrogen, a polyanhydride, an amino acid polymer, or combinations thereof. 11. The antimicrobial accessory of claim 9, wherein the base layer comprises a biodegradable polymer and an antioxidant. 12. The antimicrobial accessory of claim 11, wherein the biodegradable polymer is selected from the group consisting of poly(lactic-co-glycolic acid), poly(lactic acid), poly(glycolic acid), poly(ethylene oxide), poly(ortho ester), poly(dioxanone) a hydrophilic hydrogel, a hydrophobic hydrogen, a polyanhydride, an amino acid polymer, or combinations thereof. 13. The antimicrobial accessory of claim 11, wherein the antioxidant is selected from the group consisting of citric acid, maltol, kojic acid, malic acid, vitamin A, an ascorbate peroxidase in combination with ascorbic acid, a glutathione peroxidase in combination with glutathione, a superoxide dismutase in combination with a metal, or combinations thereof. 14. The antimicrobial accessory of claim 9, wherein the base layer comprises a pressure sensitive adhesive. 15. The antimicrobial accessory of claim 1, wherein the topcoat comprises less than approximately 9 vol. % antioxidant. 16. The antimicrobial accessory of claim 1, wherein the first layer comprises between approximately 10 wt. % antimicrobial and approximately 20 wt. % antimicrobial.
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