[특허]Preparation of an enteric release system

Preparation of an enteric release system 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/16 A61K-009/00 A61K-031/045 A61K-008/92 A23L-002/39 A61K-031/31 A61Q-013/00 A61K-031/015 A61K-031/05 A23L-001/22 A61K-008/11 A61K-009/50 A61K-008/64 A23L-002/52 A23L-001/00
출원번호	US-0976614 (2010-12-22)
등록번호	US-8859003 (2014-10-14)
발명자 / 주소	Akashe, Ahmad Gaonkar, Anilkumar Ganapati Lawrence, Les Lopez, Amado R. Haas, George W. Sebesta, Dana Wang, Yan
출원인 / 주소	Intercontinental Great Brands LLC
대리인 / 주소	Fitch, Even, Tabin & Flannery LLP
인용정보	피인용 횟수 : 0 인용 특허 : 36

초록 ▼

Hydrophobic liquids are microencapsulated by an enteric matrix in an environment substantially free of organic solvents. The process includes forming an emulsion of the enteric material and hydrophobic liquid in water, titrating the emulsion with an acid to form a particulate precipitate and optiona

대표청구항 ▼

1. A method of microencapsulating an active ingredient with an enteric matrix, the method comprising: a) agitating a combination of water and enteric materials, the combination substantially free of organic solvents, at a pH so that the enteric materials are soluble in the water to form a solution, the enteric materials including shellac and sodium caseinate;b) mixing a hydrophobic liquid containing the active ingredient into the solution;c) homogenizing the hydrophobic liquid and the solution to create an emulsion; andd) acid titrating the emulsion with an amount of acid to a pH at about an isoelectric point of sodium caseinate effective to precipitate a particulate of a plurality of hydrophobic liquid drops homogenously dispersed throughout an enteric matrix of the shellac and sodium caseinate. 2. The method of claim 1 wherein the enteric materials consist essentially of shellac and sodium caseinate. 3. The method of claim 2 wherein the shellac and sodium caseinate are provided in a ratio from about 90:10 to 10:90. 4. The method of claim 3 wherein the ratio of shellac to sodium caseinate is from about 30:70 to 70:30. 5. The method of claim 3 wherein the ratio of shellac to sodium caseinate is from about 40:60 to 60:40. 6. The method of claim 1 wherein the enteric materials are food grade. 7. The method of claim 1 further comprising applying an outer coating to the microencapsulated particulate precipitate by: e) blending an enteric coating material and a plasticizer to form a combination; andf) coating the microencapsulated particulate precipitate with the combination to provide a coated microencapsulated particulate precipitate. 8. The method of claim 7 including the steps: g) providing a second combination of a second enteric coating material and a plasticizer; andh) coating the coated microcapsulated particulate precipitate with the second combination. 9. The method of claim 8 wherein the second enteric coating material is shellac. 10. The method of claim 7 wherein the combination includes plasticizer in an amount ranging between about 1 percent to about 3 percent by weight and enteric coating material in an amount ranging between about 5 to about 20 percent by weight. 11. The method of claim 7 wherein the enteric coating material is selected from the group consisting of zein, shellac, and mixtures thereof. 12. The method of claim 7 wherein the enteric coating material is zein. 13. The method of claim 1 wherein the plasticizer is a sugar alcohol. 14. The method of claim 13 wherein the sugar alcohol is sorbitol. 15. The method of claim 1 further comprising (d1) filtering, washing and drying the particulate precipitate to produce a dry powder. 16. The method of claim 1 further comprising (a1) adding a base in an amount effective to maintain the pH between about 7 to about 12. 17. The method of claim 16 wherein the base is sodium hydroxide. 18. The method of claim 16 wherein the base is ammonium hydroxide. 19. The method of claim 1 wherein the hydrophobic liquid is selected from the group consisting of essential oils, triglycerides, unsaturated and polyunsaturated fatty acids, unsaturated and polyunsaturated lipids, beta-carotene, oil soluble vitamins and mixtures thereof. 20. A microencapsulated particulate composition comprising: a hydrophobic liquid;a matrix comprising an enteric material including shellac and sodium caseinate microencapsulating a plurality of drops of the hydrophobic liquid homogenously dispersed throughout the matrix; anda coating around the matrix, the coating including a combination of a plasticizer and an enteric coating material for covering the enteric matrix. 21. The composition of claim 20 wherein the shellac and sodium caseinate are provided in a ratio from about 90:10 to 10:90. 22. The composition of claim 21 wherein the ratio of shellac to sodium caseinate is from about 30:70 to 70:30. 23. The composition of claim 21 wherein the ratio of shellac to sodium caseinate is from about 40:60 to 60:40. 24. The composition of claim 20 wherein the enteric material consists essentially of sodium caseinate and shellac. 25. The composition of claim 20 including a second coating composition for covering the coating and including a combination of a second enteric coating material and a plasticizer. 26. The composition of claim 20 wherein the coating combination includes plasticizer in an amount ranging between about 1 percent to about 3 percent by weight and enteric material in an amount ranging between about 5 to about 20 percent by weight. 27. The composition of claim 20 wherein the plasticizer is a sugar alcohol. 28. The composition of claim 27 wherein the sugar alcohol is sorbitol. 29. The composition of claim 20 wherein the hydrophobic liquid is selected from the group consisting of essential oils, triglycerides, unsaturated and polyunsaturated fatty acids, unsaturated and polyunsaturated lipids, beta-carotene, oil soluble vitamins and mixtures thereof. 30. The method of claim 1 further comprising the steps of coating the particulate precipitate with a first coating comprising zein and then coating the particulate precipitate with a second coating comprising shellac. 31. The method of claim 1 wherein the particulate precipitate has a particle size of about 1 to about 1000 μm. 32. The method of claim 1 wherein the shellac and sodium caseinate cross-link to form the matrix. 33. The composition of claim 20 wherein the coating around the matrix comprises a first coating including zein and a second, outer coating including shellac. 34. The composition of claim 20 wherein the particulate composition has a particle size of about 1 to about 1000 μm. 35. The composition of claim 20 wherein the shellac and sodium caseinate cross-link to form the matrix.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Preparation of an enteric release system 원문보기

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